Determination of structurally conservative amino acids of the HIV-1 protein gp120 V3 loop as promising targets for drug design by protein engineering approaches

Biochemistry (Moscow)

Volumn 71, Issue 8, 2006, Pages 906-914

  Andrianov, A M ^a   Veresov, V G ^b  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

^b INSTITUTE OF PHOTOBIOLOGY   (Belarus)

Author keywords

Computer modeling; Drugs; Human immunodeficiency virus type 1; Protein gp120; Spatial structure; V3 loop

Indexed keywords

ANTIGENS; COMPUTER SIMULATION; CONFORMATIONS; DRUG PRODUCTS; PROTEINS;

COMPUTER MODELING; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; PROTEIN GP120; SPATIAL STRUCTURE; V3 LOOP;

AMINO ACIDS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GLYCOPROTEIN GP 120; HIV ENVELOPE PROTEIN GP120 (305 321); HIV ENVELOPE PROTEIN GP120 (305-321); PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG DESIGN; DRUG EFFECT; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; COMPUTER SIMULATION; CONSERVED SEQUENCE; DRUG DESIGN; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; SPECIES SPECIFICITY;

EID: 33747682832     PISSN: 00062979     EISSN: 16083040     Source Type: Journal    
DOI: 10.1134/S000629790608013X     Document Type: Article

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