NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein

Journal of Molecular Biology

Volumn 266, Issue 4, 1997, Pages 649-655

  Jelinek, Raz ^a   Terry, Tamsin D ^b   Gesell, Jennifer J ^a   Malik, Pratap ^b   Perham, Richard N ^b   Opella, Stanley J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Epitope; NMR; Peptide; Phage polypeptides; Structure

Indexed keywords

COAT PROTEIN; EPITOPE; RECOMBINANT PROTEIN; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIOPHAGE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; VIRION; X RAY CRYSTALLOGRAPHY;

ENTEROBACTERIA PHAGE FD; FILAMENTOUS BACTERIOPHAGE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031557396     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0821     Document Type: Editorial

References (32)

1. 13C enriched proteins. J. Biomol. NMR. 1:1991;99-104.
2. Brooks B. R., Bruccoleri R. E., Olafson B. D., States D. J., Swaminathan S., Karplus M. CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J. Comput. Chem. 4:1983;187-217.
3. Chandrasekhar K., Profy A. T., Dyson H. J. Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120. Biochemistry. 30:1991;9187-9194.
4. Cortese R., Felici F., Galfe G., Luzzago A., Monaci P., Nicosia A. Epitope discovery using peptide libraries displayed on phage. Trends Biotechnol. 12:1994;262-267.
5. de Lorimier R., Moody M. A., Haynes B. F., Spicer L. D. NMR-derived solution conformation of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus. Biochemistry. 33:1994;2055-2062.
6. Dyson H. J., Wright P. E. Defining solution conformations of small linear peptides. Annu. Rev. Biophys. Chem. 20:1991;519-538.
7. Felici F., Castagnoli L., Musacchio A., Jappelli R., Cesareni G. Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J. Mol. Biol. 222:1991;301-310.
8. Ghiara J. B., Stura E. A., Stanfield R. L., Profy A. T., Wilson I. A. Crystal structure of the principal neutralization site of HIV-1. Science. 264:1994;82-85.
9. Goudsmit J., Debouck C., Meloen R. H., Smit L., Bakker M., Asher D. M., Wolff A. V., Gibbs C. J., Gajdusek D. C. Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees. Proc. Natl Acad. Sci. USA. 85:1988;4478-4482.
10. Greenwood J., Willis A. E., Perham R. N. Multiple display of foreign peptides on a filmentous bacteriophage. J. Mol. Biol. 220:1991;821-827.
11. 15N NMR resonances in detergent-solubilized M13 coat-protein: a model for the coat protein dimer. Biochemistry. 31:1992;5284-5297.
12. Iannolo G., Minenkova O., Petruzzelli R., Cesareni G. Modifying filamentous phage capsid: limits in the size of the major capsid protein. J. Mol. Biol. 248:1995;835-844.
13. Javaherian K., Langlois A. J., McDanal C., Ross K. L., Eckler L. I., Jellis C. L., Profy A. T., Rusche J. R., Bolognesi D. P., Putney S. D., Matthews T. J. Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. Proc. Natl Acad. Sci. USA. 86:1989;6768-6772.
14. Kang A. S., Barbas C. F., Janda K. D., Benkovic S. J., Lerner R. A. Linkage of recognition and replication functions by assembly combinatorial antibody Fab ilbraries along phage surfaces. Proc. Natl Acad. Sci. USA. 88:1991;4363-4366.
15. Keller P. M., Arnold B. A., Shaw A. R., Tolman R. L., Van Middlesworth F., Bondy S., Rusiecki V. K., Koenig S., Zolla-Pazner S., Conard P., Emini E. A., Conley. Identification of HIV vaccine candidate peptides by screening random phage epitope libraries. Virology. 193:1993;709-716.
16. Kishchenko G., Batliwala H., Makowski L. Structure of a foreign peptide displayed on the surface of bacteriophage M13. J. Mol. Biol. 241:1994;208-213.
17. LaRosa G. J., Davide J. P., Weinhold K., Waterbury J. A., Profy A. T., Lewis J. A., Langlois A. J., Dreesman G. R., Boswell R. N., Shadduck P., Holley L. H., Karplus M., Bolognesi D. P., Matthews T. J., Emini E. A., Putney S. D. Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant. Science. 249:1990;932-935.
18. Malik P., Terry T. D., Gowda L. R., Langara A., Petukhov S. A., Symmons M. F., Welsh L. C., Marvin D. A., Perham R. N. Role of capsid structure and membrane protein processing in determining the size and copy number of peptides displayed on the major coat protein of filamentous bacteriophage. J. Mol. Biol. 260:1996;9-21.
19. McDonnell P. A., Shon K., Kim Y., Opella S. J. fd coat protein structure in membrane environments. J. Mol. Biol. 233:1993;447-463.
20. Meola A., Delmastro P., Monaci P., Luzzago A., Nicosia A., Felici F., Cortese R., Galfe G. Derivation of vaccines from mimotypes. Immunological properties of HBsAg mimotypes displayed on filamentous phage. J. Immunol. 154:1995;3162-3172.
21. Minenkova O. O., Ilyichev A. A., Kischenko G. P., Petrenko V. A. Design of specific immunogens using filamentous phage as the carrier. Gene. 128:1993;85-88.
22. Monette M., Gratkowski H., Opella S. J., Greenwood J., Willis A. E., Perham R. N. Initial characterization of a peptide epitope displayed on the surface of fd bacteriophage by solution and solid state NMR spectroscopy. Techniques in Protein Chemistry. 1996;Academic Press.
23. Opella S. J., Stewart P. L., Valentine K. G. Protein structure by solid-state NMR spectroscopy. Quart. Rev. Biophys. 18:1987;7-49.
24. Papavoine C. H. M., Konings R. N. H., Hilbers C. W., van de Ven F. J. M. Location of M13 coat protein in sodium dodecyl sulfate micelles as determined by NMR. Biochemistry. 33:1994;12990-12997.
25. Rusche J. R., Javaherian K., McDanal C., Petro J., Lynn D. L., Grimaila R., Langlois A., Gallo R. C., Arthur L. O., Fischinger P. J., Bolognesi D. P., Putney S. D., Matthews T. J. Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120. Proc. Natl Acad. Sci. USA. 85:1988;3198-3202.
26. Scherf T., Hiller R., Naider F., Levitt M., Anglister J. Induced peptide conformations in different antibody complexes: molecular modeling of the three-dimensional structure of peptide-antibody complexes using NMR-derived distance restraints. Biochemistry. 33:1992;6884-6897.
27. 15N HSQC experiments optimized to retain full sensitivity. J. Magn. Reson. ser. A. 102:1993;241-245.
28. Smith G. P., Scott J. K. Libraries of peptides and proteins displayed on filamentous phage. Methods Enzymol. 217:1993;228-257.
29. Veronese F. D. M., Willis A. E., Boyer-Thompson C., Appella E., Perham R. N. Structural mimicry and enhanced immunogenicity of peptide epitopes displayed on filamentous bacteriophage. J. Mol. Biol. 243:1994;167-172.
30. Willis A. E., Perham R. N., Wraith D. Immunological properties of foreign peptides in multiple display on fillamentous bacteriophage. Gene. 128:1993;79-83.
31. Wuthrich K. NMR of Proteins and Nucleic Acids. 1986;John Wiley and Sons, New York.
32. Zvi A., Hiller R., Anglister J. Solution conformation of a peptide corresponding to the principal neutralizing determinant of HIV-1IIIB: a two-dimensional NMR study. Biochemistry. 31:1992;6972-6979.