Generation of DC-based vaccine for therapy of B-CLL patients. Comparison of two methods for enriching monocytic precursors

Cytotherapy

Volumn 8, Issue 4, 2006, Pages 318-326

  Kokhaei, P ^a   Adamson, L ^a   Palma, M ^a   Osterborg A ^a,b   Pisa, P ^a   Choudhury, A ^a   Mellstedt, H ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptotic bodies; B CLL; Cryopreservation; DC; Immunotherapy

Indexed keywords

CANCER VACCINE; CD14 ANTIGEN; DENDRITIC CELL VACCINE;

ARTICLE; B CELL LEUKEMIA; CELL FUNCTION; CELL STRUCTURE; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; FEASIBILITY STUDY; HUMAN; HUMAN CELL; IMMUNOMAGNETIC SEPARATION; INTERMETHOD COMPARISON; LEUKAPHERESIS; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; THAWING; VACCINE PRODUCTION;

CANCER VACCINES; CELL SURVIVAL; CRYOPRESERVATION; DENDRITIC CELLS; HUMANS; IMMUNOMAGNETIC SEPARATION; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-12; LEUKEMIA, B-CELL; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MONOCYTES; PHENOTYPE; T-LYMPHOCYTES;

EID: 33747681530     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240600832656     Document Type: Article

References (28)

1. Banchereau, J and Steinman, RM. (1998) Dendritic cells and the control of immunity Nature, 392, pp. 245-52.
2. Feuerstein, B and Berger, TG and Maczek, C and (2000) A method for the production of cryopreserved aliquots of antigen- preloaded, mature dendritic cells ready for clinical use J Immunol Methods, 245, pp. 15-29.
3. Dhodapkar, MV and Steinman, RM and Sapp, M and (1999) Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells J Clin Invest, 104, pp. 173-80.
4. Stift, A and Friedl, J and Dubsky, P and (2003) Dendritic cell-based vaccination in solid cancer J Clin Oncol, 21, pp. 135-42.
5. Figdor, CG and de Vries, IJ and Lesterhuis, WJ and Melief, CJ. (2004) Dendritic cell immunotherapy: Mapping the way Nat Med, 10, pp. 475-80.
6. Dallal, RM and Lotze, MT. (2000) The dendritic cell and human cancer vaccines Curr Opin Immunol, 12, pp. 583-8.
7. Banchereau, J and Schuler-Thurner, B and Palucka, AK and Schuler, G. (2001) Dendritic cells as vectors for therapy Cell, 106, pp. 271-4.
8. Westermann, J and Korner, IJ and Kopp, J and (2003) Cryopreservation of mature monocyte-derived human dendritic cells for vaccination: Influence on phenotype and functional properties Cancer Immunol Immunother, 52, pp. 194-8.
9. Kokhaei, P and Rezvany, MR and Virving, L and (2003) Dendritic cells loaded with apoptotic tumor cells induce a stronger T-cell response than dendritic cell-tumor hybrids in B-CLL Leukemia, 17, pp. 894-9.
10. Rouard, H and Leon, A and De Reys, S and (2003) A closed and single-use system for monocyte enrichment: Potential for dendritic cell generation for clinical applications Transfusion, 43, pp. 481-7.
11. Vuillier, F and Maloum, K and Thomas, EK and (2001) Functional monocyte-derived dendritic cells can be generated in chronic lymphocytic leukemia Br J Haematol, 115, pp. 831-44.
12. Whiteside, TL and Odoux, C. (2004) Dendritic cell biology and cancer therapy Cancer Immunol Immunother, 53, pp. 240-8.
13. Kokhaei, P and Choudhury, A and Mahdian, R and (2004) Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL Leukemia, 18, pp. 1810-15.
14. Rai, KR and Sawitsky, A and Cronkite, EP and (1975) Clinical staging of chronic lymphocytic leukemia Blood, 46, pp. 219-34.
15. Adamson, L and Palmborg, A and Svensson, A and (2004) Development of a technology platform for large scale clinical grade production of DC Cytotherapy, 6, pp. 363-71.
16. Boyum, A. (1977) Separation of lymphocytes, lymphocyte subgroups and monocytes: A review Lymphology, 10, pp. 71-6.
17. Comby, E and Andre, I and Troussard, X and (1999) In vitro evaluation of B-CLL cell apoptotic responses to irradiation Leuk Lymphoma, 34, pp. 159-66.
18. Osterborg, A and Yi, Q and Henriksson, L and (1998) Idiotype immunization combined with granulocyte-macrophage colony-stimulating factor in myeloma patients induced type I, major histocompatibility complex-restricted, CD8- and CD4-specific T-cell responses Blood, 91, pp. 2459-66.
19. Hirschowitz, EA and Foody, T and Kryscio, R and (2004) Autologous dendritic cell vaccines for non-small-cell lung cancer J Clin Oncol, 22, pp. 2808-15.
20. Hayashi, T and Hideshima, T and Akiyama, M and (2003) Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes Blood, 102, pp. 1435-42.
21. Gregoire, M and Ligeza-Poisson, C and Juge-Morineau, N and Spisek, R. (2003) Anti-cancer therapy using dendritic cells and apoptotic tumor cells: Pre-clinical data in human mesothelioma and acute myeloid leukemia Vaccine, 21, pp. 791-4.
22. John, J and Hutchinson, J and Dalgleish, A and Pandha, H. (2003) Cryopreservation of immature monocyte-derived dendritic cells results in enhanced cell maturation but reduced endocytic activity and efficiency of adenoviral transduction J Immunol Methods, 272, pp. 35-48.
23. Wong, EC and Maher, VE and Hines, K and (2001) Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy Cytotherapy, 3, pp. 19-29.
24. Yannelli, JR and Sturgill, J and Foody, T and Hirschowitz, E. (2005) The large scale generation of dendritic cells for the immunization of patients with non-small cell lung cancer (NSCLC) Lung Cancer, 47, pp. 337-50.
25. Ebner, S and Ratzinger, G and Krosbacher, B and (2001) Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4 J Immunol, 166, pp. 633-41.
26. Hokey, DA and Larregina, AT and Erdos, G and (2005) Tumor cell loaded type-1 polarized dendritic cells induce Th1-mediated tumor immunity Cancer Res, 65, pp. 10059-67.
27. Vieira, PL and de Jong, EC and Wierenga, EA and (2000) Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction J Immunol, 164, pp. 4507-12.
28. Mailliard, RB and Wankowicz-Kalinska, A and Cai, Q and (2004) Alpha-type-1 polarized dendritic cells: A novel immunization tool with optimized CTL-inducing activity Cancer Res, 64, pp. 5934-7.