Anti-cancer therapy using dendritic cells and apoptotic tumour cells: Pre-clinical data in human mesothelioma and acute myeloid leukaemia

Vaccine

Volumn 21, Issue 7-8, 2003, Pages 791-794

  Gregoire, M ^a   Ligeza Poisson, C ^b   Juge Morineau, N ^b   Spisek, R ^a,c  

^a INSTITUT DE BIOLOGIE   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Apoptotic tumour cells; Dendritic; Immune therapy

Indexed keywords

2,4 DINITROPHENOL; ASBESTOS; CD4 ANTIGEN; CD8 ANTIGEN; POLYCYTIDYLIC ACID; POLYINOSINIC ACID; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOPTIVE IMMUNOTHERAPY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; BLOOD; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CANCER THERAPY; CELL ISOLATION; CELL MATURATION; COCULTURE; COMPARATIVE STUDY; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; DRUG EFFICACY; GOOD MANUFACTURING PRACTICE; HUMAN; INFLAMMATION; MESOTHELIOMA; MOLECULE; MONOCYTE; PHAGOCYTOSIS; PLEURA; PRIORITY JOURNAL; PURIFICATION; TH1 CELL; TREATMENT OUTCOME; TUMOR CELL;

APOPTOSIS; DENDRITIC CELLS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MESOTHELIOMA; NECROSIS; NEOPLASM METASTASIS;

EID: 0037472391     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00600-X     Document Type: Conference Paper

References (10)

1. Melcher A., Gough M., Todryk S., Vile R. Apoptosis or necrosis for tumor immunotherapy: what's in a name? J. Mol. Med. 77:1999;824-833.
2. Albert M.L., Sauter B., Bardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (London). 392:1998;86-89.
3. Steinman R.M., Turley S., Mellman I., Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191:2000;411-416.
4. Sauter B., Albert M.L., Francisco L., Larsson M., Somersan S., Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191:2000;423-433.
5. Boisteau O., Gautier F., Cordel S., Henry F., Harb J., Douillard J.-Y.et al. Apoptosis induced by sodium butyrate treatment increases immunogenicity of a rat colon tumor cell line. Apoptosis. 2:1997;403-412.
6. Masse D, Ebstein F, Bougras G, Spisek R, McIlroy D, Grégoire M, submitted for publication.
7. Wallin R.P.A., Lundqvist A., Moré S.M., von Bonin A., Kiessling R., Ljunggren H.-G. Heat-shock proteins as activators of the innate immune system. Trends Immunol. 23:2002;130-135.
8. Stuart L.M., Lucas M., Simpson C., Lamb J., Savill J., Lacy-Hulbert A. Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation. J. Immunol. 168:2002;1627-1635.
9. Spisek R., Bretaudeau L., Barbieux I., Meflah K., Gregoire M. Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use. Cancer Immunol. Immunother. 50:2001;417-427.
10. Spisek R., Chevallier P., Morineau N., Milpied N., Avet-Loiseau H., Harousseau J.-L.et al. Induction of leukaemia-specific cytotoxic response by cross-presentation of late-apoptotic leukaemia blasts by autologous dendritic cells of non-leukemic origin. Cancer Res. 62:2002;2861-2868.