Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles

World Journal of Gastroenterology

Volumn 12, Issue 29, 2006, Pages 4683-4688

  Hussain, Zahid ^a,c   Das, Bhudev C ^b   Husain, Syed A ^c   Polipalli, Sunil K ^a   Ahmed, Tanzeel ^a,c   Begum, Nargis ^a,c   Medhi, Subhash ^a   Verghese, Alice ^d   Raish, Mohammad ^c   Theamboonlers, Apiradee ^e   Poovorawan, Yong ^e   Kar, Premashis ^a  

^a MAULANA AZAD MEDICAL COLLEGE   (India)

^b INSTITUTE OF CYTOLOGY AND PREVENTIVE ONCOLOGY   (India)

^c JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^d NATIONAL INSTITUTE OF COMMUNICABLE DISEASES   (India)

^e KING CHULALONGKORN MEMORIAL HOSPITAL   (Thailand)

Author keywords

Immunological response; Real time PCR; Self limited acute hepatitis; Severe acute hepatitis; Viral load

Indexed keywords

ALANINE AMINOTRANSFERASE; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; EDETIC ACID; PROTHROMBIN; VIRUS RNA;

ADOLESCENT; ADULT; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENOTYPE; HEMOLYSIS; HEPATIC ENCEPHALOPATHY; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIVER FAILURE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PHYLOGENETIC TREE; PROTHROMBIN TIME; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; VIROLOGY; VIRUS LOAD;

EID: 33747677497     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i29.4683     Document Type: Article

References (38)

1. Centers for Disease Control and Prevention. 1996. Hepatitis surveillance report no. 56. Atlanta GA: Centers for Disease control. 25
2. Sjogren MH. Hepatitis A. In: Schiff ER, Sorrell MF, Maddery WC, editors. Schiff's Diseases of the Liver, 8th ed. Philadelphia: Lippincott-Raven, 1999: 745-756
3. Hadler SC. Global impact of hepatitis A virus infection changing patterns. In: Hollinger FB, Lemon SM, Margolis HS, editors. Viral hepatitis and liver disease. Baltimore, MD: Williams & Wilkins, 1991: 14-20
4. Bolke E, Flehmig B. New epidemiological patterns of hepatitis A and B infections in Germany. Zentralbl Hyg Umweltmed 1995; 196: 511-514
5. Niu MT, Polish LB, Robertson BH, Khanna BK, Woodruff BA, Shapiro CN, Miller MA, Smith JD, Gedrose JK, Alter MJ. Multistate outbreak of hepatitis A associated with frozen strawberries. J Infect Dis 1992; 166: 518-524
6. Robertson BH, Jansen RW, Khanna B, Totsuka A, Nainan OV, Siegl G, Widell A, Margolis HS, Isomura S, Ito K. Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J Gen Virol 1992; 73 (Pt 6): 1365-1377
7. Takahashi Y, Okuda K. Fulminant and subfulminant hepatitis in Japan - etiological considerations. Indian J Gastroenterol 1993; 12 Suppl 3: 19-21
8. Vento S, Garofano T, Renzini C, Cainelli F, Casali F, Ghironzi G, Ferraro T, Concia E. Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C. N Engl J Med 1998; 338: 286-290
9. Sainokami S, Abe K, Ishikawa K, Suzuki K, Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A. J Gastroenterol Hepatol 2005; 20: 1165-1175
10. Bower WA, Nainan OV, Han X, Margolis HS. Duration of viremia in hepatitis A virus infection. J Infect Dis 2000; 182: 12-17
11. Yotsuyanagi H, Iino S, Koike K, Yasuda K, Hino K, Kurokawa K. Duration of viremia in human hepatitis A viral infection as determined by polymerase chain reaction. J Med Virol 1993; 40: 35-38
12. Fujiwara K, Yokosuka O, Ehata. T, Imazeki F, Saisho H, Miki M, Omata M. Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A. Hepatology 1997; 26: 1634-1639
13. Sjogren MH, Tanno H, Fay O, Sileoni S, Cohen BD, Burke DS, Feighny RJ. Hepatitis A virus in stool during clinical relapse. Ann Intern Med 1987; 106: 221-226
14. Kedda MA, Kew MC, Cohn RJ, Field SP, Schwyzer R, Song E, Fernandes-Costa F. An outbreak of hepatitis A among South African patients with hemophilia: evidence implicating contaminated factor VIII concentrate as the source. Hepatology 1995; 22: 1363-1367
15. Chudy M, Budek I, Keller-Stanislawski B, McCaustland KA, Neidhold S, Robertson BH, Nubling CM, Seitz R, Lower J. A new cluster of hepatitis A infection in hemophiliacs traced to a contaminated plasma pool. J Med Virol 1999; 57: 91-99
16. Corey L, Holmes KK. Sexual transmission of hepatitis A in homosexual men: incidence and mechanism. N Engl J Med 1980; 302: 435-438
17. Mannucci PM. Outbreak of hepatitis A among Italian patients with haemophilia. Lancet 1992; 339: 819
18. Normann A, Graff J, Gerritzen A, Brackmann HH, Flehmig B. Detection of hepatitis A virus RNA in commercially available factor VIII preparation. Lancet 1992; 340: 1232-1233
19. Inoue K, Yoshiba M, Yotsuyanagi H, Otsuka T, Sekiyama K, Fujita R. Chronic hepatitis A with persistent viral replication. J Med Virol 1996; 30: 322-324
20. Kurane I, Binn LN, Bancroft WH, Ennis FA. Human lymphocyte responses to hepatitis A virus-infected cells: interferon production and lysis of infected cells. J Immunol 1985; 135: 2140-2144
21. Vallbracht A, Gabriel P, Zahn J, Flehmig B. Hepatitis A virus infection and the interferon system. J Infect Dis 1985; 152: 211-213
22. Vallbracht A, Gabriel P, Maier K, Hartmann F, Steinhardt HJ, Muller C, Wolf A, Manncke KH, Flehmig B. Cell-mediated cytotoxicity in hepatitis A virus infection. Hepatology 1986; 6: 1308-1314
23. Vallbracht A, Maier K, Stierhof YD, Wiedmann KH, Flehmig B, Fleischer B. Liver-derived cytotoxic T cells in hepatitis A virus infection. J Infect Dis 1989; 160: 209-217
24. Stapleton JT. Host immune response to hepatitis A virus. J Infect Dis 1995; 171 Suppl 1: S9-14
25. Cohen JI, Ticehurst JR, Purcell RH, Buckler-White A, Baroudy BM. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol 1987; 61: 50-59
26. Jansen RW, Newbold JE, Lemon SM. Complete nucleotide sequence of a cell culture-adapted variant of hepatitis A virus: comparison with wild-type virus with restricted capacity for in vitro replication. Virology 1988; 163: 299-307
27. Costa-Mattioli M, Monpoeho S, Nicand E, Aleman MH, Billaudel S, Ferre V. Quantification and duration of viraemia during hepatitis A infection as determined by real-time RTPCR. J Viral Hepat 2002; 9: 101-106
28. Hussain Z, Das BC, Husain SA, Asim M, Chattopadhyay S, Malik A, Poovorawan Y, Theamboonlers A, Kar P. Hepatitis A viral genotypes and clinical relevance: Clinical and molecular characterization of hepatitis A virus isolates from northern India. Hepatol Res 2005; 32: 16-24
29. Theamboonlers A, Jantaradsamee P, Chatchatee P, Chongsrisawat V, Mokmula M, Poovorawan Y. Molecular characterization of hepatitis-A-virus infections, in the context of two outbreaks in southern Thailand. Ann Trop Med Parasitol 2002; 96: 727-734
30. Najarian R, Caput D, Gee W, Potter SJ, Renard A, Merry-weather J, Van Nest G, Dina D. Primary structure and gene organization of human hepatitis A virus. Proc Natl Acad Sci USA 1985; 82: 2627-2631
31. Steffen R. Risk of hepatitis A in travellers. Vaccine 1992; 10 Suppl 1: S69-72
32. Flehmig B, Normann A, Bohnen D. Transmission of hepatitis A virus infection despite vaccination. N Engl J Med 2000; 343: 301-302
33. Monpoeho S, Dehee A, Mignotte B, Schwartzbrod L, Marechal V, Nicolas JC, Billaudel S, Ferre V. Quantification of enterovirus RNA in sludge samples using single tube realtime RT-PCR. Biotechniques 2000; 29: 88-93
34. Arnal C, Ferre-Aubineau V, Mignotte B, Imbert-Marcille BM, Billaudel S. Quantification of hepatitis A virus in shellfish by competitive reverse transcription-PCR with coextraction of standard RNA. Appl Environ Microbiol 1999; 65: 322-326
35. Normann A, Jung C, Vallbracht A, Flehmig B. Time course of hepatitis A viremia and viral load in the blood of human hepatitis A patients. J Med Virol 2004; 72: 10-16
36. Lyons DJ, Gilvarry JM, Fielding JF. Severe haemolysis associated with hepatitis A and normal glucose-6-phosphate dehydrogenase status. Gut 1990; 31: 838-839
37. Raffensperger EC. Acute acquired hemolytic anemia in association with acute viral hepatitis. Ann Intern Med 1958; 48: 1243-1253
38. Ajdukiewicz AB, Fox RA, Dudley FJ, Doniach D, Sherlock S. Immunological studies in an epidemic of infective, short-incubation hepatitis. Lancet 1972; 1: 803-805