Compartmental analyses of plasma 13C- and 2H-labeled n-6 fatty acids arising from oral administrations of 13C-U-18:2n-6 and 2H5-20:3n-6 in newborn infants

Pediatric Research

Volumn 60, Issue 3, 2006, Pages 327-333

  Pawlosky, Robert J ^a,e   Lin, Yu Hong ^a   Llanos, Adolfo ^b,c   Mena, Patricia ^b,c   Uauy, Ricardo ^b,d   Salem Jr , Norman ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF CHILE   (Chile)

^c HOSPITAL DR SÓTERO DEL RÍO   (Chile)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; DEUTERIUM; FATTY ACID ESTER; GAMMA LINOLENIC ACID; LINOLEIC ACID; OMEGA 6 FATTY ACID; STABLE ISOTOPE;

ARTICLE; ARTIFICIAL MILK; COMPARTMENT MODEL; CONTROLLED STUDY; DERIVATIZATION; DIETARY INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FEMALE; GAS CHROMATOGRAPHY; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; LIPID ABSORPTION; LIPID STORAGE; MALE; MASS SPECTROMETRY; NEWBORN; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SIMILAC;

8,11,14-EICOSATRIENOIC ACID; CARBON ISOTOPES; DEUTERIUM; DIETARY FATS, UNSATURATED; FATTY ACIDS, OMEGA-6; FEMALE; HUMANS; INFANT, NEWBORN; MALE;

EID: 33747628075     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000232782.09352.ef     Document Type: Article

References (24)

1. Gibson RA, Makrides M 2000 n-3 polyunsaturated FA requirements of term infants. Am J Clin Nutr 71:251S-255S.
2. Birch E, Birch D, Hoffman D, Hale L, Everett M, Uauy R 1993 Breast-feeding and optimal visual development. J Pediatr Ophthalmol Strabismus 30:33-38
3. Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C 1998 Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res 44:201-209
4. Carlson SE, Ford AJ, Werkman SH, Peeples JM, Koo WW 1996 Visual acuity and FA status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr Res 39:882-888
5. Carlson SE, Ford AJ, Werkman SH, Peeples JM, Cooke RJ, Tolley EA 1993 Arachidonic acid status correlates with first year growth in preterm infants. Proc Natl Acad Sci U S A 90:1073-1077
6. Koletzko B 1998 Lipid supply and metabolism in infancy. Curr Opin Clin Nutr Metab Care 1:171-177
7. Neuringer M, Connor WE, Petten CV, Barstad L 1984 Dietary omega-3-FA deficiency and visual loss in infant rhesus monkeys. J Clin Invest 73:272-276
8. Champoux M, Hibbeln JR, Shannon C, Majchrzak S, Suomi SJ, Salem N Jr, Higley JD 2002 FA formula supplementation and neuromotor development in rhesus monkey neonates. Pediatr Res 51:273-281
9. Food and Drug Administration 2001 Agency Response Letter GRAS Notice No. GRN 000080. http://www.cfsan.fda.gov/~rdb/opa-g080.html (accessed 27 April 2005)
10. Food and Drug Administration 2000 Agency Response Letter GRAS Notice No. GRN 000041. http://www.cfsan.fda.gov/~rdb/opa-g041.html (accessed 27 April 2005)
11. Carnielli VP, Wattimena DJ, Luijendijk IH, Boerlage A, Degenhart HJ, Sauer PJ 1996 The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. Pediatr Res 40:169-174
12. Salem N Jr, Wegher B, Mena P, Uauy R 1996 Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci U S A 93:49-54
13. Koletzko B, Demmelmair H, Hartl W, Kindermann A, Koletzko S, Sauerwald T, Szitanyi P 1998 The use of stable isotope techniques for nutritional and metabolic research in paediatrics. Early Hum Dev 53:S77S-S97.
14. Sauerwald TU, Hachey DL, Jensen CL, Chen H, Anderson RE, Heird WC 1996 Effect of dietary α-linolenic acid intake on incorporation of docosahexaenoic and arachidonic acids into plasma phospholipids of term infants. Lipids 31:S131S-S135.
15. Lubchenco LO, Hansman C, Dressler M, Boyd E 1963 Intrauterine growth as estimated from liveborn birth-weight data at 24 to 42 weeks of gestation. Pediatrics 32:793-800
16. Folch J, Lees A, Sloane-Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
17. Morrison WR, Smith LM 1964 Preparation of FA methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res 5:600-608
18. Lin YH, Salem N Jr 2005 In vivo conversion of 18- and 20-C essential fatty acids in rats using the multiple simultaneous stable isotope method. J Lipid Res 46:1962-1973.
19. Milad M, Mena P, Nieto S, Uauy R 2004 Fatty acid composition of human milk lipids in Chilean women. Acta Paediatr 93:855-856
20. Moya M, Cortes E, Juste M, De Dios JG, Vera A 2001 Fatty acid absorption in preterms on formulas with and without long-chain polyunsaturated fatty acids in terms on formulas. Eur J Clin Nutr 55:755-762
21. Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP 2005 Compartmental modeling to quantify α-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res 46:1474-1483
22. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem NJr 2001 Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42:1257-1265.
23. Pawlosky RJ, Hibbeln JR, Lin Y, Goodson S, Riggs P, Sebring N, Brown GL, Salem N Jr 2003 Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. Am J Clin Nutr 77:565-572.
24. Demmelmair H, Iser B, Raih-Pfeiffer A, Koletzko B 1999 Comparison of bolus versus fractionated oral applications of [13C]-linoleic acid in humans. Eur J Clin Invest 29:603-609