-
1
-
-
0014828868
-
A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474
-
Singh BN, Vaughan Williams EM. A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474. Br J Pharmacol. 1970;39:675-687.
-
(1970)
Br J Pharmacol
, vol.39
, pp. 675-687
-
-
Singh, B.N.1
Vaughan Williams, E.M.2
-
2
-
-
0002815844
-
Classification of antiarrhythmic agents
-
Vaughan Williams EM, ed. Berlin: Springer-Verlag; Handbook of Experimental Pharmacology Series
-
Vaughan Williams EM. Classification of antiarrhythmic agents. In Vaughan Williams EM, ed. Antiarrhythmic Drugs. Berlin: Springer-Verlag; 1989:45-67. Handbook of Experimental Pharmacology Series; No. 89.
-
(1989)
Antiarrhythmic Drugs
, Issue.89
, pp. 45-67
-
-
Vaughan Williams, E.M.1
-
4
-
-
0025164907
-
Class III antiarrhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use-dependence
-
Hondeghem LM, Snyders DJ. Class III antiarrhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use-dependence. Circulation. 1990;81:686-690.
-
(1990)
Circulation
, vol.81
, pp. 686-690
-
-
Hondeghem, L.M.1
Snyders, D.J.2
-
5
-
-
8944234858
-
Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival with Oral d-Sotalol
-
Waldo AL, Camm AJ, deRuyter H, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet. 1996;348:7-12.
-
(1996)
Lancet
, vol.348
, pp. 7-12
-
-
Waldo, A.L.1
Camm, A.J.2
DeRuyter, H.3
-
6
-
-
0035901578
-
Instability and triangulation of the action potential predict serious proarrhythrnia, but APD prolongation is antiarrhythmic
-
Hondeghem L, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythrnia, but APD prolongation is antiarrhythmic. Circulation. 2001;103:2004-2013.
-
(2001)
Circulation
, vol.103
, pp. 2004-2013
-
-
Hondeghem, L.1
Carlsson, L.2
Duker, G.3
-
7
-
-
2542457330
-
Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
-
Valentin JP, Hoffmann P, De Clerck F, Hammond TG, Hondeghem L. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. J Pharmacol Toxicol Methods. 2004;49:171-181
-
(2004)
J Pharmacol Toxicol Methods
, vol.49
, pp. 171-181
-
-
Valentin, J.P.1
Hoffmann, P.2
De Clerck, F.3
Hammond, T.G.4
Hondeghem, L.5
-
8
-
-
21344463329
-
Refining detection of drug-induced proarrhythmia: QT interval and TRIaD
-
Shah RR, Hondeghem LM. Refining detection of drug-induced proarrhythmia: QT interval and TRIaD. Heart Rhythm. 2005;2:758-772.
-
(2005)
Heart Rhythm
, vol.2
, pp. 758-772
-
-
Shah, R.R.1
Hondeghem, L.M.2
-
9
-
-
6444237997
-
Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs
-
Thomsen MB, Verduyn SC, Stengl M, et al. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation. 2004;110:2453-2459.
-
(2004)
Circulation
, vol.110
, pp. 2453-2459
-
-
Thomsen, M.B.1
Verduyn, S.C.2
Stengl, M.3
-
11
-
-
0037215510
-
Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability
-
Hondeghem LM, Hoffmann P. Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability. J Cardiovasc Pharmacol. 2003;41:14-24.
-
(2003)
J Cardiovasc Pharmacol
, vol.41
, pp. 14-24
-
-
Hondeghem, L.M.1
Hoffmann, P.2
-
14
-
-
0037020439
-
Drug-induced long QT in isolated rabbit Purkinje fibers: Importance of action potential duration, triangulation and early afterdepolarizations
-
Lu HR, Vlaminckx E, Van Ammel K, De Clerck F. Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations. Eur J Pharmacol. 2002;452:183-192.
-
(2002)
Eur J Pharmacol
, vol.452
, pp. 183-192
-
-
Lu, H.R.1
Vlaminckx, E.2
Van Ammel, K.3
De Clerck, F.4
-
15
-
-
0037782488
-
Effects of clinically available drugs on the repolarization process of the heart assessed by the in vivo canine models
-
Sugiyama A. Effects of clinically available drugs on the repolarization process of the heart assessed by the in vivo canine models. Nippon Yakurigaku Zasshi. 2003;121:393-400.
-
(2003)
Nippon Yakurigaku Zasshi
, vol.121
, pp. 393-400
-
-
Sugiyama, A.1
-
16
-
-
0036784524
-
Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: Fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes
-
Milberg P, Eckardt L, Bruns HJ, et al. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. J Pharmacol Exp Ther. 2002;303:218-225.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 218-225
-
-
Milberg, P.1
Eckardt, L.2
Bruns, H.J.3
-
17
-
-
0036139125
-
Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: Low torsadogenic potential despite QT prolongation
-
Eckardt L, Breithardt G, Haverkamp W. Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. J Pharmacol Exp Ther. 2002;300:64-71.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 64-71
-
-
Eckardt, L.1
Breithardt, G.2
Haverkamp, W.3
-
18
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
Redfern WS, Carlsson L, Davis AS, et al. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res. 2003;58:32-45.
-
(2003)
Cardiovasc Res
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
-
19
-
-
1442301518
-
The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: Influence of multi-channel block
-
Martin RL, McDermott JS, Salmen HJ, Palmatier J, Cox BF, Gintant GA. The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block. J Cardiovasc Pharmacol. 2004;43:369-379.
-
(2004)
J Cardiovasc Pharmacol
, vol.43
, pp. 369-379
-
-
Martin, R.L.1
McDermott, J.S.2
Salmen, H.J.3
Palmatier, J.4
Cox, B.F.5
Gintant, G.A.6
-
20
-
-
0142209158
-
Drug induced QT prolongation and torsades de pointes
-
Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes. Heart. 2003;89:1363-1372.
-
(2003)
Heart
, vol.89
, pp. 1363-1372
-
-
Yap, Y.G.1
Camm, A.J.2
-
21
-
-
23844532061
-
TRIaD: Foundation for proarrhythmia (triangulation, reverse use dependence, and instability)
-
Novartis Foundation Symposium 266. New York: Wiley
-
Hondeghem LM. TRIaD: foundation for proarrhythmia (triangulation, reverse use dependence, and instability). In The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome. Novartis Foundation Symposium 266. New York: Wiley; 2005:235-250.
-
(2005)
The HERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome
, pp. 235-250
-
-
Hondeghem, L.M.1
|