A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression

Xenotransplantation

Volumn 13, Issue 5, 2006, Pages 455-464

  Omori, Takeshi ^a   Nishida, Toshirou ^a   Komoda, Hiroshi ^a   Fumimoto, Yuichi ^a   Ito, Toshinori ^a   Sawa, Yoshiki ^a   Gao, Congxiao ^a   Nakatsu, Shino ^a   Shirakura, Ryota ^a   Miyagawa, Shuji ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Gal antigen; Complement; Hanganutziu Deicher antigen; N linked sugar; Neonatal porcine islet like cell cluster; Pig islets

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; DECAY ACCELERATING FACTOR; GALACTOSAMINE; GALACTOSYL ALPHA 1,3 GALACTOSYL BETA 1,4 N ACETYLGLUCOSAMINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; N ACETYLGLUCOSAMINE; SIALIDASE; TUNICAMYCIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HYPERACUTE GRAFT REJECTION; IMMUNOGLOBULIN DEPOSITION; INSULIN DEPENDENT DIABETES MELLITUS; NEONATAL PORCINE ISLET LIKE CELL CLUSTER; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; SWINE; XENOTRANSPLANTATION;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD55; ANTIGENS, HETEROPHILE; BLOOD PHYSIOLOGICAL PHENOMENA; BLOOD PHYSIOLOGY; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C4; COMPLEMENT FACTOR B; FEMALE; GENETIC VECTORS; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MORPHOLINES; NEURAMINIDASE; OLIGOSACCHARIDES; SWINE; TRANSPLANTATION, HETEROLOGOUS; TUNICAMYCIN;

EID: 33747603226     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00335.x     Document Type: Article

References (32)

1. COOPER DK. Clinical xenotransplantion - how close are we? Lancet 2003; 362: 557.
2. MIYAGAWA S, HIROSE H, SHIRAKURA R et al. The mechanism of discordant xenograft rejection. Transplantation 1988; 46: 825.
3. PLATT JL. New directions for organ transplantation. Nature 1998; 392(Suppl): 11.
4. GROTH CG, KORSGREN O, TIBELL A et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994; 344: 1402.
5. VALDES-GONZALEZ RA, DORANTES LM, GARIBAY GN et al. Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study. Eur J Endocrinol 2005; 153: 419.
6. MURAKAMI H, NAGASHIMA H, TAKAHAGI Y et al. Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter. Mol Reprod Dev 2002; 61: 302.
7. BENNET W, BJORKLAND A, SUNDBERG B et al. Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Transplantation 2001; 72: 312.
8. COOPER DKC, KOREN E, ORIOL R. Oligosaccharides and discordant xenotransplantation. Immunol Rev 1994; 141: 31.
9. SANDRIN MS, FODOR W, MOUHTOURIS E et al. Enzymatic remodeling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med 1995; 1: 1261.
10. TANEMURA M, MIYAGAWA S, IHARA Y et al. Significant downregulation of the major swine xenoantigen by N-acetylglucosaminyltransferase III gene transfection. Biochem Biophys Res Chem 1997; 235: 359.
11. MIYAGAWA S, MURAKAMI H, TAKAHAGI Y et al. Remodeling of the major pig xenoantigen by N-acetylglucosaminyltransferase III in transgenic pig. J Biol Chem 2001; 276: 39310.
12. PHELPS CJ, KOIKE C, VAUGHT TD et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411.
13. NISHIMAKI T, KANO K, MILGROM F. Hanganutziu-Deicher antigen and antibody in pathologic sera and tissues. J Immunol 1979; 122: 2314.
14. KOMODA H, MIYAGAWA S, KUBO T et al. A study of the xenoantigenicity of adult pig islet cells. Xenotransplantation 2004; 11: 237.
15. KORBUTT GS, ELLIOT JF, ZILIANG AO et al. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 1996; 97: 2119.
16. ASAOKA H, NISHINAKA S, WAKAMIYA N, MATSUDA H, MURATA M. Two chicken monoclonal antibodies specific for heterophil Hanganutziu-Deicher antigens. Immunol Lett 1992; 32: 91.
17. FUKUTA D, MIYAGAWA S, KUBO T et al. Effect of hybrid complement regulatory proteins on xenogeneic cells. Biochem Biophys Res Commun 2003; 306: 476.
18. UCHIBORI E, KITANO E, TSUJI T, KITAMURA H. Study on CH50 levels in factor D-depleted serum. Rinsho Byori 2002; 50: 815.
19. NAGAKI K, TSUBOI M, MATSUMOTO M, KITAMURA H. A simple one-step hemolytic assay of the first component of human complement (C1) with polyethylene glycol treated human serum: details of the assay procedures and its application to the C1 activation study. J Clin Lab Immunol 1986; 21: 141.
20. PLATTS-MILLS TA, ISHIZAKA K. Activation of the alternate pathway of human complements by rabbit cells. J Immunol 1974; 113: 348.
21. MIYAGAWA S, SHIRAKURA R, IWATA K et al. Effects of transfected complement regulatory proteins, MCP, DAF, and MCP/DAF hybrid, on complement-mediated swine endotherial cell lysis. Transplantation 1994; 58: 834.
22. BENNET W, SUNDBERG B, LUNDGREN T et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000; 69: 711.
23. RAYAT GR, RAJOTTE RV, HERING BJ, BINETTE TM, KORBUTT GS. In vitro and in vivo expression of Gal alpha-(1,3)Gal on porcine islet cells is age dependent. J Endocrinol 2003; 177: 127.
24. IRIE A, KOYAMA S, KOZUTSUMI Y, KAWASAKI T, SUZUKI A. The molecular basis for the absence of N-glycolylneuraminic acid in humans. J Biol Chem 1998; 273: 15866.
25. MOROZUMI K, KOBAYASHI T, USAMI T et al. Significance of histochemical expression of Hanganutziu-Deicher antigens in pig, baboon and human tissues. Transplant Proc 1999; 31: 942.
26. MURASE A, MIYAGAWA S, KOMA M et al. An attempt to downregulate the Hanganutziu-Deicher antigen by overexpression of glycosyltransferases. Transplant Proc 2000; 32: 2507.
27. KOBAYASHI T, YOKOYAMA I, SUZUKI A et al. Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history. Xenotransplantation 2000; 7: 177.
28. ZHU A, HURST R. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation 2002; 9: 376.
29. MIWA Y, KOBAYASHI T, NAGASAKA T et al. Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation? Xenotransplantation 2004; 11: 247.
30. FUJITA T. Evolution of the lectin-complement pathway and its role in innate immunity. Nat Rev Immunol 2002; 2: 346.
31. MATSUSHITA M, FUJITA T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med 1992; 176: 1497.
32. SCHMIDT P, GOTO M, LE MAUFF B, ANEGON I, KORSGREN O. Adenovirus-mediated expression of human CD55 or CD59 protects adult porcine islets from complement-mediated cell lysis by human serum. Transplantation 2003; 75: 697.