The relationship between proliferating cell nuclear antigen expression and histomorphometrical alterations in cyclosporin A-induced gingival overgrowth in rats

Toxicologic Pathology

Volumn 34, Issue 2, 2006, Pages 180-186

  Cetinkaya, Burcu Ozkan ^a   Acikgoz, Gokhan ^a   Aydin, Oguz ^a   Korkmaz, Adnan ^a   Keles, Gonca Cayir ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Cyclosporine A; Gingival overgrowth; PCNA; Rats

Indexed keywords

CYCLINE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; GINGIVA; GINGIVA OVERGROWTH; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; CELL PROLIFERATION; CYCLOSPORINE; EPITHELIUM; GENE EXPRESSION REGULATION; GINGIVA; GINGIVAL OVERGROWTH; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR;

EID: 33747600645     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230600611778     Document Type: Article

References (42)

1. Ayanoglou, C. M., and Lesty, C. (1999). Cyclosporin A-induced gingival overgrowth in the rat: a histological, ultrastructural and histomorphometric evaluation. J Periodontal Res 34, 7-15.
2. Bartold, P. M. (1987). Cyclosporine and gingival overgrowth. J Oral Pathol 16, 463-8.
3. Calne, R. Y., Rolles, K., White, D. J., Thiru, S., Evans, D. B., McMaster, P., Dunn, D. C., Craddock, G. N., Henderson, R. G., Aziz, S., and Lewis, P. (1979). Cyclosporin A initially as the only immunosupresant 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases and 2 livers. Lancet 2, 1033-6. (Pubitemid 10213970)
4. Cebeci, I., Kantarci A., Firatli, E., Aygun, S., Tanyeri, H., Aydin, A. E., Carin, M., Guc, U., and Tuncer, O. (1996). Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. J Clin Periodontol 23, 737-42. (Pubitemid 126732024)
5. Celenligil-Nazliel, H., Ayhan, A., Uzun, H., and Ruacan, S. (2000). The effect of age on proliferating cell nuclear antigen expression in oral gingival epithelium of healthy and inflamed human gingiva. J Periodontol 71, 1567-74.
6. Daley, T. D., and Wysocki, G. P. (1984). Cyclosporine therapy. Its significance to the periodontist. Journal of Periodontology 55, 708-12. (Pubitemid 15152387)
7. Das, S. J., Parkar, M. H., and Olsen, I. (2001). Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. J Periodontol 72, 745-52. (Pubitemid 32565611)
8. Deliliers, G. L., Santoro, F., Polli, N., Bruno, E., Fumagalli, L., and Risciotti, E. (1986). Light and electron microscopic study of cyclosporin A-induced gingival hyperplasia. J Periodontol 57, 771-5. (Pubitemid 17222963)
9. Friskopp, J., Engstrom, P. E., and Sundqvist, K. G. (1986). Characterization of mononuclear cells in cyclosporin A induced gingival enlargement. Scand J Dent Res 94, 443-7. (Pubitemid 17198106)
10. Fu, E., Nieh, S., Chang, H. L., and Wang, S. L. (1995). Dose-dependent gingival overgrowth induced by cyclosporin in rats. J Periodontol 66, 594-8.
11. Fu, E., Nieh, S., and Wikesjo, U. M. (1997). The effect of plaque retention on cyclosporine-induced gingival overgrowth in rats. J Periodontol 68, 92-8. (Pubitemid 27099502)
12. Kataoka, M., Shimizu, Y., Kunikiyo, K., Asahara, Y., Yamashita, K., Ninomiya, M., Morisaki, I., Ohsaki, Y., Kido, J. I., and Nagata, T. (2000). Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth. J Cell Physiol 182, 351-8. (Pubitemid 30054368)
13. Keles, G. C., Acikgoz, G., Ayas, B., Sakallioglu, E., and Firatli, E. (2005). Determination of systemically & locally induced periodontal defects in rats. Indian J Med Res 121, 176-84. (Pubitemid 40528740)
14. Kitamura, K., Morisaki, I., Adachi, C., Kato, K., Mihara, J., Sobue, S., and Hamada, S. (1990). Gingival overgrowth induced by cyclosporin A in rats. Arch Oral Biol 35, 483-6.
15. Kurki, P., Vanderlaan, M., Dolbeare, F., Gray, J., and Tan, E. M. (1986). Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res 166, 209-19. (Pubitemid 16030469)
16. Laupacis, A., Keown, P. A., Ulan, R. A., McKenzie, N., and Stiller, C. R.(1982). Cyclosporin A: a powerful immunosuppressant. Can Med Assoc J 126, 1041-6. (Pubitemid 12120231)
17. Marwah, A., Meyer, J., and Weinmann, J. P. (1956). Mitotic rate of gingival epithelium in two age groups. J Invest Dermatol 27, 237-47.
18. Mathews, M. B., Bernstein, R. M., Franza, B. R., and Garrels, J. I. (1984). Identity of the proliferating cell nuclear antigen and cyclin. Nature 309, 374-6. (Pubitemid 14145846)
19. McGaw, T., Lam, S., and Coates, J. (1987). Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surg Oral Med Oral Path 64, 293-7. (Pubitemid 17148018)
20. McGaw, W. T., and Porter, H. (1988). Cyclosporine-induced gingival overgrowth: an ultrastructural stereologic study. Oral Surg Oral Med Oral Pathol 65, 186-90. (Pubitemid 18062292)
21. Miyachi, K., Fritzler, M. J., and Tan, E. M. (1978). Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121, 2228-34. (Pubitemid 9075187)
22. Morisaki, I., Kitamura, K., Kato, K., Marukawa, Y., and Mihara, J. (1993). Age dependency of cyclosporin A-induced gingival overgrowth in rats. Pediatr Dent 15, 414-17.
23. Morisaki, I., Akiyama, Y. M., Miyawaki, Y. N., Mori, Y. (1997). Positive correlation between blood cyclosporin A level and severity of gingival overgrowth in rats. J Periodontol 68, 7-11. (Pubitemid 27099498)
24. Niimi, A., Tohnai, I., Kaneda, T., Takeuchi, M., and Nagura, H. (1990). Immunohistochemical analysis of effects of cyclosporin A on gingival epithelium. J Oral Pathol Med 19, 397-403. (Pubitemid 20377040)
25. Nishikawa, S., Nagata, T., Morisaki, I., Oka, T., and Ishida, H. (1996). Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model. J Periodontol 67, 463-71. (Pubitemid 126449799)
26. Nurmenniemi, P. K., Pernu, H. E., and Knuuttila, M.L. (2001). Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. J Periodontol 72, 167-73. (Pubitemid 32539489)
27. Papapanou, P. N., and Lindhe, J. (2003). Epidemiology of periodontal diseases. In Clinical Periodontology and Implant Dentistry (J. Lindhe, T. Karring, N. P. Lang, eds.), pp. 50-80. Blackwell Publishing, Paris, France.
28. Pernu, H. E., Pernu, L. M., Huttunen, K. R., Nieminen, P. A., and Knuuttila, M. L. (1992). Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol 63, 548-53.
29. Pilatti, G. L., and Sampaio, J. E. (1997). The influence of chlorhexidine on the severity of cyclosporin A-induced gingival overgrowth. J Periodontol 68, 900-4. (Pubitemid 27411023)
30. Rateitschak-Plüss, E. M., Hefti, A., Lörtscher, R., and Thiel, G. (1983). Gingival hyperplasia from cyclosporin A medication. J Clin Periodontol 10, 237-46.
31. Rostock, M. H., Fry, H. R., and Turner, J. E. (1986). Severe gingival overgrowth associated with cyclosporine therapy. J Periodontol 57, 294-9. (Pubitemid 17010295)
32. Seibel, W., Yahia, N. A., McCleary, L. B., Lesko, L. J., and Hassell, T. M. (1989). Cyclosporine-induced gingival overgrowth in beagle dogs. J Oral Pathol Med 18, 240-5. (Pubitemid 19197325)
33. Seymour, R. A., Ellis, J. S., and Thomason, J. M. (2000). Risk factors for drug-induced gingival overgrowth. J Clin Periodontol 27, 217-23.
34. Seymour, R. A., and Smith, D. G. (1991). The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes. J Clin Periodontol 18, 107-10.
35. Spolidorio, L. C., Merzel, J., Villalba, H., Vargas, P. A., Coletta, R. D., and Almeida, O. P. (2001). Morphometric evaluation of gingival overgrowth and regression caused by cyclosporin in rats. J Periodontal Res 36, 384-9. (Pubitemid 33633335)
36. Spolidorio, L. C., Spolidorio, D. M., Neves, K. A., Gonzaga, H. F., and Almeida, O. P. (2002). Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats. J Periodontal Res 37, 192-5.
37. Spolidorio, L. C., Spolidorio, D. M., Benatti, C., Sampaio, J. E., and Almeida, O. P. (2003). Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent. J Periodontal Res 38, 375-9. (Pubitemid 37465543)
38. Tyldesley, W. R., and Rotter, E. (1984). Gingival hyperplasia induced by cyclosporin-A. Br Dent J 157, 305-9.
39. Wassef, R., Cohen, Z., and Langer, B. (1985). Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage. Transplantation 40, 489-93. (Pubitemid 16196198)
40. Wong, R. L., Winslow, C. M., and Cooper, K. D. (1993). The mechanisms of action of cyclosporin A in the treatment of psoriasis. Immunol Today 2, 69-74. (Pubitemid 23046166)
41. Wysocki, G., and Daley, T. (1987). Hypertrichosis in patients receiving cyclosporine therapy. Clin Exp Dermatol 12, 191-6. (Pubitemid 17063776)
42. Zidar, N., Gale, N., Cör, A., and Kambic, V. (1996). Expression of Ki-67 and malignant epithelial lesions of the larynx. J Laryngol Otolol 110, 440-5.