Morphological evaluation of combined effects of cyclosporin and nifedipine on gingival overgrowth in rats

Journal of Periodontal Research

Volumn 37, Issue 3, 2002, Pages 192-195

  Spolidorio, L C ^a   Spolidorio, D M ^a   Neves, K A ^a   Gonzaga, H F S ^a   Almeida, O P ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cyclosporin A, nifedipine; Gingival overgrowth

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; FIBRILLAR COLLAGEN; IMMUNOSUPPRESSIVE AGENT; NIFEDIPINE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD VESSEL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; FIBROBLAST; GINGIVA; GINGIVA OVERGROWTH; MALE; PATHOLOGY; RAT; VASCULARIZATION; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD VESSELS; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DRUG SYNERGISM; FIBRILLAR COLLAGENS; FIBROBLASTS; GINGIVA; GINGIVAL OVERGROWTH; IMMUNOSUPPRESSIVE AGENTS; MALE; NIFEDIPINE; RATS; RATS, WISTAR;

EID: 0036595372     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0765.2002.00028.x     Document Type: Article

References (30)

1. Marshall RI, Bartold PM. Medication induced gingival overgrowth. Oral Dis 1998,4:130-151.
2. Seymour RA. Jacobs DJ Cyclosporin and the gingival tissues J Clin Periodontol 1992;19:1-11.
3. Thomason JM, Seymour RA, Rice N. The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. J Clin Periodontol 1993;20:37-40.
4. Margiotta V, Pizzo I, Pizzo G, Barbaro A Cyclosporin- and nifedipine- induced gingival overgrowth in renal transplant patients correlations with periondontal and pharmacological parameters and HLA antigens J Oral Pathol Med 1996;25:128-134.
5. Thomason JM, Seymour RA, Ellis JS et al Iatrogenic gingival overgrowth in cardiac transplantation. J Periodontol 1995; 66:742-746.
6. Morisaki I, Fukui N, Fujimori Y, Murakami J, Daikoku H, Amano A. Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats J Periodontol 2000;71:438-443.
7. Willershausen-Zönnchen B, Lemmen C, Schumacher U. Influence of cyclosporin A on growth and extracellular matrix synthesis of human fibroblasts. J Cell Physiol 1992,152:397-402.
8. Ayanoglou CM, Lesty C. Cyclosporin A-induced gingival overgrowth in the rat: a histological, ultrastructural and histomorphometric evaluation. J Periodont Res 1999;34:7-15.
9. Bolzani G, Colleta RD, Martelli HJ et al. Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts. J Periodont Res 1999;34:1-8.
10. Baiak S, Engelberg IS, Hiss J Gingival hyperplasia caused by nifedipine. Histopathological findings J Periodont Res 1987;58:639-642
11. Bencini, PL, Crosti C, Sala F et al Gingival hyperplasia by nifedipine Report of a case. Acta Derm Venereol 1985,65:362-365.
12. Wassef R, Cohen Z, Langer B. Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage. Transplantation 1985;40:489-493.
13. Morisaki I, Kato K, Loyola-Rodrigues JP et al. Nifedipine-induced gingival overgrowth in the presence or absence of gingival inflammation in rats J Periodont Res 1993;28:396-403.
14. Fischer RG, Klinge B. Clinical and histological evaluation of ligature-induced periodontal breakdown in domestic ferrets immunosuppressed by cyclosporin-A J Clin Periodontol 1994;21:240-249.
15. Delesse MA. Procédé mécanique pour determiner la composition des roches CR Acad Sce 1848;25:544.
16. Weibel ER. Selection of the best method in stercology. J Microsc 1974,100:261-269
17. Kataoka M, Shimizu Y, Kunikiyo K. et al. Cyclosporin A decreases the degradation of type 1 collagen in rat gingival overgrowth J Cell Physiol 2000;182:351-358.
18. Wysocki GP, Gretzinger HA, Laupacis A et al Fibrous hyperplasia of the gingiva: a side effect of cyclosporin-A therapy Oral Surg Oral Med Oral Pathol 1983;55:274-278.
19. Wondimu B, Reinholt FP, Modéer T. Stereologic study of cyclosporin-A induced gingival overgrowth in renal transplant patients. Eur J Oral Sci 1995;103: 199-206
20. Macgaw WT, Porter H. Cyclosporine-induced gingival overgrowth an ultrastructural Stereologic study. Oral Surg Oral Med Oral Pathol 1988;65:186-190.
21. Dill RE, Miller EK, Weil T et al. Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes J Periodontol 1993,64:169-173.
22. Seymour RA, Smith DG The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes. J Clin Periodontol 1991; 18:107-110.
23. Somacarrera ML, Hernández G, Acero J, Moskow BS. Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994, 65:671-675.
24. Pernu HE, Pernu LNH, Knuuttila MLE, Huttunen KRH Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors J Periodontol 1992;63:548-553.
25. Tipton DA, Stricklin GP, Dabbous MK. Fibroblast heterogeneity in collagenolytic response to cyclosporine. J Cell Biochem 1991;46:152-165.
26. Zebrowsky EJ, Singer DL, Brunka JR Cyclosporin-A, nifedipine and phenytoin comparative effects on gingival fibroblast metabolism J Dent Rev 1986;65:331.
27. Hassell TM, Romberg E, Sobhani S et al. Lymphocyte-mediated effects of cyclosporin on human fibroblasts. Transplant Proc 1988;20:993-1002
28. Numi A, Tohnai I, Kaneda T et al. Immunohistochemical analysis of effects of cyclosporin A on gingival epithelium. J Oral Pathol Med 1990;19:397-403.
29. Hill MW, Mackenzie IC The influence of differing connective tissue substrates on the maintenance of adult stratified squamous epithelia. Cell Tissue Res 1984;237: 473-478.
30. Mackenzie IC, Hill MW, Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse. Cell Tissue Res 1984;235:551-559.