메뉴 건너뛰기




Volumn 8, Issue 3, 2006, Pages 188-195

Pathogenesis of idiopathic inflammatory myopathies

Author keywords

[No Author keywords available]

Indexed keywords

ANTI AMINOACYL TRNA SYNTHETASE ANTIBODY; ANTI JO 1 ANTIBODY; ANTI MI 2 ANTIBODY; ANTI SIGNAL RECOGNITION PARTICLE; AUTOANTIBODY; UNCLASSIFIED DRUG;

EID: 33747597988     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-996-0024-4     Document Type: Article
Times cited : (14)

References (50)
  • 1
    • 0026354417 scopus 로고
    • A new approach to the classification of idiopathic inflammatory myopathy: Myositis-specific autoantibodies define useful homogeneous patient groups
    • Love LA, Leff RL, Fraser DD, et al.: A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991, 70:360-374.
    • (1991) Medicine (Baltimore) , vol.70 , pp. 360-374
    • Love, L.A.1    Leff, R.L.2    Fraser, D.D.3
  • 2
    • 0035132757 scopus 로고    scopus 로고
    • Autoantibody profiles in the sera of European patients with myositis
    • Brouwer R, Hengstman GJ, Vree Egberts W, et al.: Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 2001, 60:116-123. This study focused on autoantibody reactivity in a large cohort of European patients with myositis.
    • (2001) Ann Rheum Dis , vol.60 , pp. 116-123
    • Brouwer, R.1    Hengstman, G.J.2    Vree Egberts, W.3
  • 3
    • 0025641623 scopus 로고
    • The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity
    • Miller FW, Waite KA, Biswas T, et al.: The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity. Proc Natl Acad Sci U S A 1990, 87:9933-9937.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 9933-9937
    • Miller, F.W.1    Waite, K.A.2    Biswas, T.3
  • 4
    • 0029790410 scopus 로고    scopus 로고
    • Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis
    • Arnett FC, Targoff IN, Mimori T, et al.: Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis. Arthritis Rheum 1996, 39:1507-1518.
    • (1996) Arthritis Rheum , vol.39 , pp. 1507-1518
    • Arnett, F.C.1    Targoff, I.N.2    Mimori, T.3
  • 5
    • 14244267901 scopus 로고    scopus 로고
    • Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    • Casciola-Rosen L, Nagaraju K, Plotz P, et al.: Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005, 201:591-601. In this highly interesting paper the authors present support for tissue specific variations in autoantigen quantity. They also suggest a linkage between malignancies and dermatomyositis through the Mi-2 antigen which was highly expressed in tumor tissues.
    • (2005) J Exp Med , vol.201 , pp. 591-601
    • Casciola-Rosen, L.1    Nagaraju, K.2    Plotz, P.3
  • 6
    • 0037120002 scopus 로고    scopus 로고
    • Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    • Howard OM, Dong HF, Yang D, et al. : Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med 2002, 196:781-791. In this study the authors present interesting evidence suggesting that autoantigens in myositis, such as the histidyl-tRNA synthetase, could function as chemokines. This observation suggests an important role of these autoantigens in disease mechanisms of myositis.
    • (2002) J Exp Med , vol.196 , pp. 781-791
    • Howard, O.M.1    Dong, H.F.2    Yang, D.3
  • 7
    • 0021176654 scopus 로고
    • Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells
    • Arahata K, Engel AG: Monoclonal antibody analysis of mononuclear cells in myopathies. I: quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol 1984, 16:193-208.
    • (1984) Ann Neurol , vol.16 , pp. 193-208
    • Arahata, K.1    Engel, A.G.2
  • 8
    • 0024604938 scopus 로고
    • Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies
    • Emslie-Smith AM, Arahata K, Engel AG: Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies. Hum Pathol 1989, 20:224-231.
    • (1989) Hum Pathol , vol.20 , pp. 224-231
    • Emslie-Smith, A.M.1    Arahata, K.2    Engel, A.G.3
  • 9
    • 0347719268 scopus 로고    scopus 로고
    • Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: Interaction with chemokines and Th1 cytokine-producing cells
    • Page G, Chevrel G, Miossec P: Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: interaction with chemokines and Th1 cytokine-producing cells. Arthritis Rheum 2004, 50:199-208. This is a first paper to clearly demonstrate presence of dendritic cells, both immature and mature, in muscle tissue of polymyositis and dermatomyositis patients.
    • (2004) Arthritis Rheum , vol.50 , pp. 199-208
    • Page, G.1    Chevrel, G.2    Miossec, P.3
  • 10
    • 20944450759 scopus 로고    scopus 로고
    • Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis
    • Greenberg SA, Pinkus JL, Pinkus GS, et al.: Interferon-alpha/beta- mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005, 57:664-678. In this paper the authors used microarray analysis in combination with immunohistochemistry on human muscle tissue to find support for a role of the IFN-α system in disease mechanisms in adult cases with dermatomyositis.
    • (2005) Ann Neurol , vol.57 , pp. 664-678
    • Greenberg, S.A.1    Pinkus, J.L.2    Pinkus, G.S.3
  • 11
    • 0036788192 scopus 로고    scopus 로고
    • Interferon-induced mx proteins: Dynamin-like GTPases with antiviral activity
    • Haller O, Kochs G: Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity. Traffic 2002, 3:710-717.
    • (2002) Traffic , vol.3 , pp. 710-717
    • Haller, O.1    Kochs, G.2
  • 12
    • 0029153736 scopus 로고
    • High endothelial venules (HEVs): Specialized endothelium for lymphocyte migration
    • Girard JP, Springer TA: High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today 1995, 16:449-457.
    • (1995) Immunol Today , vol.16 , pp. 449-457
    • Girard, J.P.1    Springer, T.A.2
  • 13
    • 0034790176 scopus 로고    scopus 로고
    • Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies
    • Englund P, Lindroos E, Nennesmo I, et al.: Skeletal muscle fibers express major histocompatibility complex class II antigens independently of inflammatory infiltrates in inflammatory myopathies. Am J Pathol 2001, 159:1263-1273.
    • (2001) Am J Pathol , vol.159 , pp. 1263-1273
    • Englund, P.1    Lindroos, E.2    Nennesmo, I.3
  • 14
    • 0034041459 scopus 로고    scopus 로고
    • Increased expression of interleukin 1alpha and MHC class I in muscle tissue of patients with chronic, inactive polymyositis and dermatomyositis
    • Nyberg P, Wikman AL, Nennesmo I, et al.: Increased expression of interleukin 1alpha and MHC class I in muscle tissue of patients with chronic, inactive polymyositis and dermatomyositis. J Rheumatol 2000, 27:940-948.
    • (2000) J Rheumatol , vol.27 , pp. 940-948
    • Nyberg, P.1    Wikman, A.L.2    Nennesmo, I.3
  • 15
    • 0032797798 scopus 로고    scopus 로고
    • Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in inflammatory myopathies
    • Murata K, Dalakas MC: Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in inflammatory myopathies. Am J Pathol 1999, 155:453-460.
    • (1999) Am J Pathol , vol.155 , pp. 453-460
    • Murata, K.1    Dalakas, M.C.2
  • 16
    • 0037116094 scopus 로고    scopus 로고
    • Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome
    • Murata KY, Sugie K, Takamure M, et al.: Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome. J Neurol Sci 2002, 205:65-70.
    • (2002) J Neurol Sci , vol.205 , pp. 65-70
    • Murata, K.Y.1    Sugie, K.2    Takamure, M.3
  • 17
    • 0032400949 scopus 로고    scopus 로고
    • Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions
    • Behrens L, Kerschensteiner M, Misgeld T, et al.: Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions. J Immunol 1998, 161:5943-5951.
    • (1998) J Immunol , vol.161 , pp. 5943-5951
    • Behrens, L.1    Kerschensteiner, M.2    Misgeld, T.3
  • 18
    • 0031647766 scopus 로고    scopus 로고
    • Molecular immunology and genetics of inflammatory muscle diseases
    • Dalakas MC: Molecular immunology and genetics of inflammatory muscle diseases. Arch Neurol 1998, 55:1509-1512.
    • (1998) Arch Neurol , vol.55 , pp. 1509-1512
    • Dalakas, M.C.1
  • 19
    • 0028807858 scopus 로고
    • Analysis of cytokine expression in muscle in inflammatory myopathies, Duchenne dystrophy, and non-weak controls
    • Lundberg I, Brengman JM, Engel AG: Analysis of cytokine expression in muscle in inflammatory myopathies, Duchenne dystrophy, and non-weak controls. J Neuroimmunol 1995, 63:9-16.
    • (1995) J Neuroimmunol , vol.63 , pp. 9-16
    • Lundberg, I.1    Brengman, J.M.2    Engel, A.G.3
  • 20
    • 0030904859 scopus 로고    scopus 로고
    • Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies
    • Lundberg I, Ulfgren AK, Nyberg P, et al.: Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum 1997, 40:865-874.
    • (1997) Arthritis Rheum , vol.40 , pp. 865-874
    • Lundberg, I.1    Ulfgren, A.K.2    Nyberg, P.3
  • 21
    • 0034659757 scopus 로고    scopus 로고
    • Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: Role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production
    • Sugiura T, Kawaguchi Y, Harigai M, et al.: Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production. J Immunol 2000, 164:6593-6600.
    • (2000) J Immunol , vol.164 , pp. 6593-6600
    • Sugiura, T.1    Kawaguchi, Y.2    Harigai, M.3
  • 22
    • 0033538970 scopus 로고    scopus 로고
    • Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle
    • Schoser BG, Blottner D: Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle. Neuroreport 1999, 10:2795-2797.
    • (1999) Neuroreport , vol.10 , pp. 2795-2797
    • Schoser, B.G.1    Blottner, D.2
  • 23
    • 0036116405 scopus 로고    scopus 로고
    • Matrix metalloproteinases in inflammatory myopathies: Enhanced immunoreactivity near atrophic myofibers
    • Schoser BG, Blottner D, Stuerenburg HJ: Matrix metalloproteinases in inflammatory myopathies: enhanced immunoreactivity near atrophic myofibers. Acta Neurol Scand 2002, 105:309-313.
    • (2002) Acta Neurol Scand , vol.105 , pp. 309-313
    • Schoser, B.G.1    Blottner, D.2    Stuerenburg, H.J.3
  • 24
    • 0033981058 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies
    • Choi YC, Dalakas MC: Expression of matrix metalloproteinases in the muscle of patients with inflammatory myopathies. Neurology 2000, 54:65-71.
    • (2000) Neurology , vol.54 , pp. 65-71
    • Choi, Y.C.1    Dalakas, M.C.2
  • 25
    • 0035122693 scopus 로고    scopus 로고
    • Expression of specific matrix metalloproteinases in inflammatory myopathies
    • Kieseier BC, Schneider C, Clements JM, et al.: Expression of specific matrix metalloproteinases in inflammatory myopathies. Brain 2001, 124:341-351.
    • (2001) Brain , vol.124 , pp. 341-351
    • Kieseier, B.C.1    Schneider, C.2    Clements, J.M.3
  • 26
    • 0029996726 scopus 로고    scopus 로고
    • Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
    • Wang J, Walsh K: Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 1996, 273:359-361.
    • (1996) Science , vol.273 , pp. 359-361
    • Wang, J.1    Walsh, K.2
  • 27
    • 0033005249 scopus 로고    scopus 로고
    • Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis
    • Sugiura T, Murakawa Y, Nagai A, et al.: Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis. Arthritis Rheum 1999, 42:291-298.
    • (1999) Arthritis Rheum , vol.42 , pp. 291-298
    • Sugiura, T.1    Murakawa, Y.2    Nagai, A.3
  • 28
    • 0034658072 scopus 로고    scopus 로고
    • The inhibition of apoptosis in myositis and in normal muscle cells
    • Nagaraju K, Casciola-Rosen L, Rosen A, et al.: The inhibition of apoptosis in myositis and in normal muscle cells. J Immunol 2000, 164:5459-5465.
    • (2000) J Immunol , vol.164 , pp. 5459-5465
    • Nagaraju, K.1    Casciola-Rosen, L.2    Rosen, A.3
  • 29
    • 0034237432 scopus 로고    scopus 로고
    • Expression of human IAP-like protein in skeletal muscle: A possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies
    • Li M, Dalakas MC: Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies. J Neuroimmunol 2000, 106:1-5.
    • (2000) J Neuroimmunol , vol.106 , pp. 1-5
    • Li, M.1    Dalakas, M.C.2
  • 30
    • 0036788751 scopus 로고    scopus 로고
    • Apoptosis and muscle fibre loss in neuromuscular disorders
    • Tews DS: Apoptosis and muscle fibre loss in neuromuscular disorders. Neuromuscul Disord 2002, 12:613-622.
    • (2002) Neuromuscul Disord , vol.12 , pp. 613-622
    • Tews, D.S.1
  • 31
    • 0022619727 scopus 로고
    • Microvascular deposition of complement membrane attack complex in dermatomyositis
    • Kissel JT, Mendell JR, Rammohan KW: Microvascular deposition of complement membrane attack complex in dermatomyositis. N Engl J Med 1986, 314:329-334.
    • (1986) N Engl J Med , vol.314 , pp. 329-334
    • Kissel, J.T.1    Mendell, J.R.2    Rammohan, K.W.3
  • 32
    • 0025366230 scopus 로고
    • Microvascular changes in early and advanced dermatomyositis: A quantitative study
    • Emslie-Smith AM, Engel AG: Microvascular changes in early and advanced dermatomyositis: a quantitative study. Ann Neurol 1990, 27:343-356.
    • (1990) Ann Neurol , vol.27 , pp. 343-356
    • Emslie-Smith, A.M.1    Engel, A.G.2
  • 33
    • 0345700857 scopus 로고    scopus 로고
    • Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis
    • Chung YL, Wassif WS, Bell JD, et al.: Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis. Rheumatology (Oxford) 2003, 42:298-303.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 298-303
    • Chung, Y.L.1    Wassif, W.S.2    Bell, J.D.3
  • 34
    • 0025804383 scopus 로고
    • Modulation of endothelial function by hypoxia: Perturbation of barrier and anticoagulant function, and induction of a novel factor X activator
    • Ogawa S, Shreeniwas R, Butura C, et al.: Modulation of endothelial function by hypoxia: perturbation of barrier and anticoagulant function, and induction of a novel factor X activator. Adv Exp Med Biol 1990, 281:303-312.
    • (1990) Adv Exp Med Biol , vol.281 , pp. 303-312
    • Ogawa, S.1    Shreeniwas, R.2    Butura, C.3
  • 35
    • 0034121666 scopus 로고    scopus 로고
    • Decreased expression of interleukin-1alpha, interleukin-1beta, and cell adhesion molecules in muscle tissue following corticosteroid treatment in patients with polymyositis and dermatomyositis
    • Lundberg I, Kratz AK, Alexanderson H, et al.: Decreased expression of interleukin-1alpha, interleukin-1beta, and cell adhesion molecules in muscle tissue following corticosteroid treatment in patients with polymyositis and dermatomyositis. Arthritis Rheum 2000, 43:336-348.
    • (2000) Arthritis Rheum , vol.43 , pp. 336-348
    • Lundberg, I.1    Kratz, A.K.2    Alexanderson, H.3
  • 36
    • 0027102386 scopus 로고
    • Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface
    • Shreeniwas R, Koga S, Karakurum M, et al.: Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 1992, 90:2333-2339.
    • (1992) J Clin Invest , vol.90 , pp. 2333-2339
    • Shreeniwas, R.1    Koga, S.2    Karakurum, M.3
  • 37
    • 0036719311 scopus 로고    scopus 로고
    • Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion
    • Salven P, Hattori K, Heissig B, et al.: Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion. Faseb J 2002, 16:1471-1473.
    • (2002) Faseb J , vol.16 , pp. 1471-1473
    • Salven, P.1    Hattori, K.2    Heissig, B.3
  • 38
    • 0033623788 scopus 로고    scopus 로고
    • Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells
    • El Awad B, Kreft B, Wolber EM, et al.: Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells. Kidney Int 2000, 58:43-50.
    • (2000) Kidney Int , vol.58 , pp. 43-50
    • El Awad, B.1    Kreft, B.2    Wolber, E.M.3
  • 39
    • 0025943515 scopus 로고
    • Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts
    • Falanga V, Qian SW, Danielpour D, et al.: Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts. J Invest Dermatol 1991, 97:634-637.
    • (1991) J Invest Dermatol , vol.97 , pp. 634-637
    • Falanga, V.1    Qian, S.W.2    Danielpour, D.3
  • 41
    • 23644462864 scopus 로고    scopus 로고
    • Exercise: An important component of treatment in the idiopathic inflammatory myopathies
    • Alexanderson H: Exercise: an important component of treatment in the idiopathic inflammatory myopathies. Curr Rheumatol Rep 2005, 7:115-124.
    • (2005) Curr Rheumatol Rep , vol.7 , pp. 115-124
    • Alexanderson, H.1
  • 42
    • 0347125204 scopus 로고    scopus 로고
    • Diagnostic value of MHC class I staining in idiopathic inflammatory myopathies
    • van der Pas J, Hengstman GJ, ter Laak HJ, et al.: Diagnostic value of MHC class I staining in idiopathic inflammatory myopathies. J Neurol Neurosurg Psychiatry 2004, 75:136-139. The authors tested the sensitivity and specificity of MHC class I expression on the sarcolemma in 224 muscle samples. They found a sensitivity of 78% and a specificity of 95% suggesting that this staining could be a valid test for diagnosis of inflammatory myopathies.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 136-139
    • Van Der Pas, J.1    Hengstman, G.J.2    Ter Laak, H.J.3
  • 43
    • 10744220559 scopus 로고    scopus 로고
    • Class I MHC detection as a diagnostic tool in noninformative muscle biopsies of patients suffering from dermatomyosit is [DM]
    • Civatte M, Schleinitz N, Krammer P, et al.: Class I MHC detection as a diagnostic tool in noninformative muscle biopsies of patients suffering from dermatomyosit is [DM]. Neuropathol Appl Neurobiol 2003, 29:546-552.
    • (2003) Neuropathol Appl Neurobiol , vol.29 , pp. 546-552
    • Civatte, M.1    Schleinitz, N.2    Krammer, P.3
  • 44
    • 0031660980 scopus 로고    scopus 로고
    • A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli
    • Nagaraju K, Raben N, Merritt G, et al.: A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli. Clin Exp Immunol 1998, 113:407-414.
    • (1998) Clin Exp Immunol , vol.113 , pp. 407-414
    • Nagaraju, K.1    Raben, N.2    Merritt, G.3
  • 45
    • 0011261078 scopus 로고    scopus 로고
    • Conditional upregulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
    • Nagaraju K, Raben N, Loeffler L, et al.: Conditional upregulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A 2000, 97:9209-9214. The authors present an interesting animal model for myositis based on a genetically modulated mouse model with up-regulation of MHC class I in muscle fibers. This model suggests that up-regulation of MHC class I in skeletal muscle fibers by itself may cause muscle weakness before damage of muscle fibers occurs.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9209-9214
    • Nagaraju, K.1    Raben, N.2    Loeffler, L.3
  • 46
    • 20744448833 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction
    • Nagaraju K, Casciola-Rosen L, Lundberg I, et al.: Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis Rheum 2005, 52:1824-1835. In this report a new molecular pathway, independent of cell-mediated muscle fiber damage, was identified in both humans with dermatomyositis and in a transgene mouse model with MHC class I expression in muscle fibers. This could be an important contributing mechanism that could lead to muscle weakness in myositis patients.
    • (2005) Arthritis Rheum , vol.52 , pp. 1824-1835
    • Nagaraju, K.1    Casciola-Rosen, L.2    Lundberg, I.3
  • 47
    • 0023921176 scopus 로고
    • Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells
    • Allison J, Campbell IL, Morahan G, et al.: Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 1988, 333:529-533.
    • (1988) Nature , vol.333 , pp. 529-533
    • Allison, J.1    Campbell, I.L.2    Morahan, G.3
  • 48
    • 0025944623 scopus 로고
    • Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes
    • Turnley AM, Morahan G, Okano H, et al.: Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature 1991, 353:566-569.
    • (1991) Nature , vol.353 , pp. 566-569
    • Turnley, A.M.1    Morahan, G.2    Okano, H.3
  • 49
    • 0037102398 scopus 로고    scopus 로고
    • Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: Involvement of muscle myofilaments
    • Reid MB, Lannergren J, Westerblad H: Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments. Am J Respir Crit Care Med 2002, 166:479-484.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 479-484
    • Reid, M.B.1    Lannergren, J.2    Westerblad, H.3
  • 50
    • 2342661145 scopus 로고    scopus 로고
    • Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with poly myositis and dermatomyositis treated with corticosteroids
    • Ulfgren AK, Grundtman C, Borg K, et al.: Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with poly myositis and dermatomyositis treated with corticosteroids. Arthritis Rheum 2004, 50:1586-1594. A very interesting new pro-inflammatory cytokine, high mobility group box (HMGB) 1, which is constitutively expressed in cell nuclei, was detected extracellularly in muscle tissue from myositis patients indicating a role in triggering the immune response in these disorders. Furthermore, it was still present extranuclearly in endothelial cells and muscle fibers after corticosteroid treatment, therefore this cytokine could be an important molecule contributing to chronicity of muscle inflammation.
    • (2004) Arthritis Rheum , vol.50 , pp. 1586-1594
    • Ulfgren, A.K.1    Grundtman, C.2    Borg, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.