Increased toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 61, Issue 2, 2006, Pages 293-298

  Cairns, Bruce ^a,b   Maile, Robert ^a   Barnes, Carie M ^a   Frelinger, Jeffrey A ^a   Meyer, Anthony A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; HERMES ANTIGEN; MONOCLONAL ANTIBODY CD3; OKT 4; OKT 8; STREPTAVIDIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURN; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCALD; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD44; BURNS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; SPLEEN; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTOR 4;

EID: 33747595429     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/01.ta.0000228969.46633.bb     Document Type: Article

References (24)

1. Pruitt BA Jr. Forces and factors influencing trauma care: 1983 American Association for the Surgery of Trauma Presidential address. J Trauma. 1984;24:463-470.
2. Herndon DN, Tompkins RG. Support of the metabolic response to burn injury. Lancet. 2004;363:1895-1902.
3. Cioffi WG. What's new in burns and metabolism. J Am Coll Surg. 2001;192:241-254.
4. Bello YM, Falabella AF, Eaglstein WH. Tissue-engineered skin. Current status in wound healing. Am J Clin Dermatol. 2001;2:305-313.
5. Cairns BA, deSerres S, Peterson HD, et al. Skin replacements. The biotechnological quest for optimal wound closure. Arch Surg. 1993;128:1246-1252.
6. Tschoeke SK, Moldawer LL. Human leukocyte antigen expression in sepsis: what have we learned? Crit Care Med. 2005;33:236-237.
7. Murphy TJ, Choileain NN, Zang Y, et al. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol. 2005;174:2957-2963.
8. Richters CD, Hoekstra MJ, du Pont JS, et al. Immunology of skin transplantation. Clin Dermatol. 2005;23:338-342.
9. Hultman CS, Cairns BA, deSerres S, et al. Burn injury impairs second-set rejection and CTL reactivity in mice primed by cultured keratinocyte allografts. Transplantation. 1995;60:584-589.
10. Hultman CS, Cairns BA, Yamamoto H, et al. The 1995 Moyer Award. The effect of burn injury on allograft rejection, alloantigen processing, and cytotoxic T-lymphocyte sensitization. J Burn Care Rehabil. 1995;16:573-580.
11. Hultman CS, Cairns BA, deSerres S, et al. Early, complete burn wound excision partially restores cytotoxic T lymphocyte function. Surgery. 1995;118:421-429.
12. Hunt JP, Hunter CT, Brownstein MR, et al. The effector component of the cytotoxic T-lymphocyte response has a biphasic pattern after burn injury. J Surg Res. 1998;80:243-251.
13. Cairns BA, Maile R, Buchanan I, et al. CD8(+) T cells express a T-helper 1-like phenotype after burn injury. Surgery. 2001;130:210-216.
14. Buchanan IB, Maile R, Frelinger JA, et al. The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation. J Trauma. 2005; in press.
15. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004;5:987-995.
16. Murphy TJ, Paterson HM, Mannick JA, et al. Injury, sepsis, and the regulation of Toll-like receptor responses. J Leukoc Biol. 2004;75:400-407.
17. Sakaguchi S. Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors. J Exp Med. 2003;197:397-401.
18. Caramalho I, Lopes-Carvalho T, Ostler D, et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med. 2003;197:403-411.
19. Xu D, Komai-Koma M, Liew FY. Expression and function of Toll-like receptor on T cells. Cell Immunol. 2005;233:85-89.
20. Komai-Koma M, Jones L, Ogg GS, et al. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A. 2004;101:3029-3034.
21. Peng G, Guo Z, Kiniwa Y, et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science. 2005;309:1380-1384.
22. Paterson HM, Murphy TJ, Purcell EJ, et al. Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol. 2003;171:1473-1483.
23. Dutton RW, Bradley LM, Swain SL. T cell memory. Annu Rev Immunol. 1998;16:201-223.
24. Calvano SE, Xiao W, Richards DR, et al. A network-based analysis of systemic inflammation in humans. Nature. 2005;437:1032-1037.