Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial

Nicotine and Tobacco Research

Volumn 8, Issue 4, 2006, Pages 555-564

  Rennard, Stephen I ^a   Glover, Elbert D ^b   Leischow, Scott ^c   Daughton, David M ^a   Glover, Penny N ^b   Muramoto, Myra ^d   Franzon, Mikael ^e   Danielsson, Tobias ^e   Landfeldt, Björn ^e   Westin, Åke ^e  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e Pfizer Consumer Healthcare   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; COTININE; NICOTINE; NICOTINE GUM; PLACEBO; THIOCYANATE;

ADULT; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CIGARETTE SMOKING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DISEASE MARKER; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EXPIRED AIR; EXPLORATORY RESEARCH; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; INHALER; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PARALLEL DESIGN; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SELF REPORT; SMOKING CESSATION; STATISTICAL SIGNIFICANCE; THROAT IRRITATION; TOBACCO DEPENDENCE; TREATMENT OUTCOME; VOMITING; WILCOXON SIGNED RANKS TEST;

ADMINISTRATION, INHALATION; ADULT; CARBON MONOXIDE; DOUBLE-BLIND METHOD; FEMALE; GANGLIONIC STIMULANTS; HUMANS; MALE; MIDDLE AGED; NICOTINE; QUALITY OF LIFE; SMOKING CESSATION; TOBACCO USE DISORDER; TREATMENT OUTCOME;

EID: 33747594556     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1080/14622200600789916     Document Type: Article

References (46)

1. Benowitz, N. L. and Hall, S. M. and Herning, R. I. and Jacob, P. I. and Jones, R. T. and Osman, A. L. (1983) Smokers of low yield cigarettes do not consume less nicotine. The New England Journal of Medicine, 309, pp. 139-142.
2. Biener, L. and Abrams, D. B. (1991) The Contemplation Ladder: Validation of a measure of readiness to consider smoking cessation. Health Psychology, 10, pp. 360-365.
3. Bolliger, C. T. and Zellweger, J. P. and Danielsson, T. and van Biljon, X. and Robidou, A. and Westin, A. and Perruchoud, A. P. and Sawe, U. (2000) Smoking reduction with oral nicotine inhalers: Double blind, randomised clinical trial of efficacy and safety [see comments]. British Medical Journal, 321, pp. 329-333.
4. Bolliger, C. T. and Zellweger, J. P. and Danielsson, T. and van Biljon, X. and Robidou, A. and Westin, A. and Perruchoud, A. P. and Sawe, U. (2002) Influence of long-term smoking reduction on health risk markers and quality of life. Nicotine & Tobacco Research, 4, pp. 433-439.
5. Boyle, P. and Gandini, S. and Robertson, C. (2000) International Smokers Survey Group. Characteristics of smokers' attitudes towards stopping: Survey of 10,295 smokers in representative samples from 17 European countries. European Journal of Public Health, 10, pp. 5-14.
6. Carpenter, M. J. and Hughes, J. R. and Solomon, L. J. and Callas, P. W. (2004) Both smoking reduction with nicotine replacement therapy and motivational advice increase future cessation among smokers unmotivated to quit. Journal of Consulting and Clinical Psychology, 72, pp. 371-381.
7. Cinciripini, P. M. and Lapitsky, L. and Seay, S. and Wallfisch, A. and Kitchens, K. and Vunakis, H. (1995) Effects of smoking schedules on cessation outcome: Can we improve on common methods of gradual and abrupt nicotine withdrawal. Journal of Consulting and Clinical Psychology, 63, pp. 388-399.
8. Eliasson, B. and Hjalmarson, A. and Kruse, E. and Landfeldt, B. and Westin, A. (2001) Effect of smoking reduction and cessation on cardiovascular risk factors. Nicotine & Tobacco Research, 3, pp. 249-255.
9. Etter, J. F. and Laszlo, E. and Zellweger, J. P. and Perrot, C. and Perneger, T. V. (2002) Nicotine replacement to reduce cigarette consumption in smokers who are unwilling to quit: A randomized trial. Journal of Clinical Psychopharmacology, 22, pp. 487-495.
10. Etter, J. F. and Perneger, T. V. and Ronchi, A. (1997) Distributions of smokers by stage: International comparison and association with smoking prevalence. Preventive Medicine, 26, pp. 580-585.
11. Fagerström, K. O. (1999) Interventions for treatment-resistant smokers. Nicotine & Tobacco Research, 1((Suppl.)), pp. S201-S205.
12. Fagerström, K. O. and Hughes, J. R. (2002) Nicotine concentrations with concurrent use of cigarettes and nicotine replacement: A review. Nicotine & Tobacco Research, 4((Suppl. 2)), pp. S73-S79.
13. Fagerström, K. O. and Ramstrom, L. (1998) Can smokeless tobacco rid us of tobacco smoke? American Journal of Medicine, 104, pp. 501-503.
14. Hatsukami, D. K. and Slade, J. and Benowitz, N. L. and Giovino, G. A. and Gritz, E. R. and Leischow, S. and Warner, K. E. (2002) Reducing tobacco harm: Research challenges and issues. Nicotine & Tobacco Research, 1((Suppl.)), pp. S89-S101.
15. Hays, R. D. and Sherbourne, C. D. and Mazel, R. M. (1993) The RAND 36-item health survey 1.0. Health Economics, 2, pp. 217-227.
16. Heatherton, T. F. and Kozlowski, L. T. and Frecker, R. C. and Fagerström, K.-O. (1991) The Fagerström Test for Nicotine Dependence: A revision of the Fagerström Tolerance Questionnaire. British Journal of Addiction, 86, pp. 1119-1127.
17. Hjalmarson, A. and Nilsson, F. and Sjostrom, L. and Wiklund, O. (1997) The nicotine inhaler in smoking cessation. Archives of Internal Medicine, 157, pp. 1721-1728.
18. Hofer, I. and Nil, R. and Battig, K. (1991) Nicotine yield as determinant of smoke exposure indicators and puffing behavior. Pharmacology, Biochemistry, and Behavior, 40, pp. 139-149.
19. Hughes, J. R. (2000) Reduced smoking: An introduction and review of the evidence. Addiction, 95((Suppl. 1)), pp. S3-S7.
20. Hughes, J. R. and Cummings, K. M. and Hyland, A. (1999) Ability of smokers to reduce their smoking and its association with future smoking cessation. Addiction, 94, pp. 109-114.
21. Institute of Medicine.(2001). In Clearing the smoke: Assessing the science base for tobacco harm reduction. Washington D.C.: National Academies Press.
22. Jimenez-Ruiz, C. and Kunze, M. and Fagerström, K. O. (1998) Nicotine replacement: A new approach to reducing tobacco-related harm. European Respiratory Journal, 11, pp. 473-479.
23. Jimenez-Ruiz, C. and Solano, S. and Viteri, S. A. and Ferrero, M. B. and Torrecilla, M. and Mezquita, M. H. (2002) Harm reduction - A treatment approach for resistant smokers with tobacco-related symptoms. Respiration, 69, pp. 452-455.
24. Johnston, L. D. and O'Malley, P. M. and Bachman, J. G.(2003). In. Bethesda MD: National Institute on Drug Abuse. Monitoring the Future national survey results on drug use, 1975-2002. Volume I: Secondary school students (NIH Publication No. 03-5375)
25. Kozlowski, L. T. (2002) Harm reduction, public health, and human rights: Smokers have a right to be informed of significant harm reduction options. Nicotine & Tobacco Research, 4((Suppl. 2)), pp. S55-S60.
26. Kozlowski, L. T. and Goldberg, M. E. and Yost, B. A. and White, E. L. and Sweeney, C. T. and Pillitteri, J. L. (1998) Smokers' misperceptions of light and ultra-light cigarettes may keep them smoking. American Journal of Preventive Medicine, 15, pp. 9-16.
27. Leischow, S. J. and Nilsson, F. and Franzon, M. and Hill, A. and Otte, P. S. and Merikle, E. P. (1996) Efficacy of the nicotine inhaler as an adjunct to smoking cessation. American Journal of Health Behavior, 20, pp. 364-371.
28. Leischow, S. J. and Ranger-Moore, J. and Muramoto, M. L. and Matthews, E. (2004) Effectiveness of the nicotine inhaler for smoking cessation in an OTC setting. American Journal of Health Behavior, 28, pp. 291-301.
29. Lunell, E. and Molander, L. and Leischow, S. J. and Fagerström, K. O. (1995) Effect of nicotine vapour inhalation on the relief of tobacco withdrawal symptoms. European Journal of Clinical Pharmacology, 48, pp. 235-240.
30. Mahmarian, J. J. and Moye, L. A. and Nasser, G. A. (1997) Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia. Journal of the American College of Cardiology, 30, pp. 125-130.
31. Murray, R. and Bailey, W. C. and Daniels, K. and Bjornson, W. and Kurnow, K. and Connett, E. and Nides, M. A. and Kiley, J. P. (1996) Safety of nicotine polacrilex gum used by 3,094 participants in the Lung Health Study. Chest, 109, pp. 438-445.
32. Petitti, D. B. and Friedman, G. D. (1983) Evidence for compensation in smokers of low yield cigarettes. International Journal of Epidemiology, 12, pp. 487-489.
33. Rennard, S. I. and Daughton, D. and Fujita, J. and Oehlerking, M. B. and Dobson, J. R. and Stahl, M. G. and Robbins, R. A. and Thompson, A. B. (1990) Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers. European Respiratory Journal, 3, pp. 752-759.
34. Rennard, S. I. and Umino, T. and Millatmal, T. and Daughton, D. M. and Manouilova, L. S. and Ullrich, F. A. and Patil, K. D. and Romberger, D. J. and Floreani, A. A. and Anderson, J. R. (2002) Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobacco. Nicotine & Tobacco Research, 4, pp. 467-476.
35. Russell, M. A. H. and Sutton, S. R. and Feyerabend, C. and Saloojee, Y. (1980) Smokers' response to shortened cigarettes: Dose reduction without dilution of tobacco smoke. Clinical Pharmacology and Therapeutics, 27, pp. 210-218.
36. Scherer, G. (1999) Smoking behaviour and compensation: A review of the literature. Psychopharmacology, 145, pp. 1-20.
37. Schneider, N. G. and Olmstead, R. E. and Franzon, M. A. and Lunell, E. (2001) The nicotine inhaler: Clinical pharmacokinetics and comparison with other nicotine treatments. Clinical Pharmacokinetics, 40, pp. 661-684.
38. Shiffman, S. and Mason, K. M. and Henningfield, J. E. (1998) Tobacco dependence treatments: Review and prospectus. Annual Review of Public Health, 19, pp. 335-358.
39. Stahl, M. M. and Wohlfart, B. and Pahlm, O. (2001) Tolerability of concurrent use of nicotine gum and smoking in healthy volunteers. Nicotine & Tobacco Research, 3, pp. 157-165.
40. Sutton, S. R. and Feyerabend, C. and Cole, P. V. and Russell, M. A. (1978) Adjustment of smokers to dilution of tobacco smoke by ventilated cigarette holders. Clinical Pharmacology and Therapeutics, 24, pp. 395-405.
41. Sutton, S. R. and Russell, M. A. and Iyer, R. and Feyerabend, C. and Saloojee, Y. (1982) Relationship between cigarette yields, puffing patterns, and smoke intake: Evidence for tar compensation? British Medical Journal, 285, pp. 600-603.
42. Tonneson, P. and Norregaard, J. and Mikkelsen, K. and Jorgensen, S. and Nilsson, F. (1993) A double-blind trial of a nicotine inhaler for smoking cessation. The Journal of the American Medical Association, 269, pp. 1268-1271.
43. U.S. Department of Health and Human Services. (1989). Reducing the health consequences of smoking: 25 years of progress. A report of the surgeon general (DHHS Publication No. CDC890-8411) Washington, DC. U.S. Government Printing Office
44. U.S. Department of Health and Human Services.(1990). In. Rockville MD: Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Public Health Service. The health benefits of smoking cessation. A report of the surgeon general (DHHS Publication No. CDC90-8416)
45. U.S. Department of Health, Education and Welfare.(1984). In Smoking and health: Report of the advisory committee to the surgeon general of the Public Health Service. (pp. 14-57). Washington DC: U.S. Government Printing Office.
46. Wennike, P. and Danielsson, T. and Landfeldt, B. and Westin, A. and Tonnesen, P. (2003) Smoking reduction promotes smoking cessation: Results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up. Addiction, 98, pp. 1395-1402.