The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels

Journal of Neuroscience

Volumn 26, Issue 2, 2006, Pages 685-695

  Mohapatra, Durga P ^a   Trimmer, James S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetylcholine; Calcineurin; Calcium; Hippocampus; Intracellular signaling; Kv2.1; Neuromodulation

Indexed keywords

RECOMBINANT PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; NERVE CELL CULTURE; NERVE STIMULATION; NEUROMODULATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CALCINEURIN; CALCIUM; CARBACHOL; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIPPOCAMPUS; HUMANS; ION CHANNEL GATING; ION TRANSPORT; IONOMYCIN; KIDNEY; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MUSCARINIC AGONISTS; NERVE TISSUE PROTEINS; NEURONS; ORGAN SPECIFICITY; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POTASSIUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, MUSCARINIC; RECOMBINANT FUSION PROTEINS; SHAB POTASSIUM CHANNELS; SINGLE-BLIND METHOD; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 32544451419     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4620-05.2006     Document Type: Article

References (49)

1. Antonucci DE, Lim ST, Vassanelli S, Trimmer JS (2001) Dynamic localization and clustering of dendritic Kv2.1 voltage-dependent potassium channels in developing hippocampal neurons. Neuroscience 108:69-81.
2. + current in a vertebrate neurone. Nature 283:673-676.
3. 2+ flux. Cell 83:463-472.
4. + channels. Ann NY Acad Sci 868:233-285.
5. + channels. Cell Signal 9:551-573.
6. + channel, Kv2.1, is apposed to astrocytic processes and is associated with inhibitory postsynaptic membranes in hippocampal and cortical principal neurons and inhibitory interneurons. Neuroscience 84:37-48.
7. + channel subunit Kv2.1. J Physiol (Lond) 522:19-31.
8. + channel subunit kv2.2 in brain stem and hypothalamic neurons. Circ Res 84:352-359.
9. Gluzman Y (1981) SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23:175-182.
10. Graham FL, Smiley J, Russell WC, Nairn R (1977) Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36:59-74.
11. + current in the pleural sensory neurons of Aplysia by serotonin and cAMP: implications for spike broadening. Proc Natl Acad Sci USA 89:11476-11480.
12. Huang XY, Morielli AD, Peralta EG (1993) Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell 75:1145-1156.
13. + channels of the Shab subfamily. J Neurosci 13:1569-1576.
14. 2+ mobilization in cultured rat hippocampal neurones. J Physiol (Lond) 511:747-759.
15. Jonas EA, Kaczmarek LK (1996) Regulation of potassium channels by protein kinases. Curr Opin Neurobiol 6:318-323.
16. Klein M, Camardo J, Kandel ER (1982) Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia. Proc Natl Acad Sci USA 79:5713-5717.
17. Klemic KG, Shieh CC, Kirsch GE, Jones SW (1998) Inactivation of Kv2.1 potassium channels. Biophys J 74:1779-1789.
18. + channels. J Biol Chem 277:29045-29053.
19. Lee KB, Pals-Rylaarsdam R, Benovic JL, Hosey MM (1998) Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors. J Biol Chem 273:12967-12972.
20. Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218-3226.
21. Levey AI, Edmunds SM, Koliatsos V, Wiley RG, Heilman CJ (1995) Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation. J Neurosci 15:4077-4092.
22. Levitan IB (1994) Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu Rev Physiol 56:193-212.
23. Levitan IB (1999) Modulation of ion channels by protein phosphorylation. How the brain works. Adv Second Messenger Phosphoprotein Res 33:3-22.
24. + channel in hippocampal neurons. Neuron 25:385-397.
25. Lucas-Meunier E, Fossier P, Baux G, Amar M (2003) Cholinergic modulation of the cortical neuronal network. Pflügers Arch 446:17-29.
26. 2+ channels. Science 287:1647-1651.
27. + currents, IK, are encoded by Kv2 α-subunits and regulate tonic firing in mammalian sympathetic neurons. J Neurosci 22:10094-10105.
28. + channels. Eur J Biochem 267:5830-5836.
29. 2+ channels in hippocampal neurons. Nature 395:900-905.
30. Misonou H, Trimmer JS (2005) A primary culture system for biochemical analyses of neuronal proteins. J Neurosci Methods 144:165-173.
31. Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS (2004) Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci 7:711-718.
32. + channel critical to dynamic control of neuronal excitability. Neurotoxicology 26:743-752.
33. Misonou H, Mohapatra DP, Menegola M, Trimmer JS (2005b) Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia. J Neurosci 25: 11184-11193.
34. 2+ changes in hippocampal neurons. Neuron 6:901-905.
35. + current in rat hippocampal neurons. J Neurosci 19:1728-1735.
36. + channel alters voltage-dependent activation. Mol Pharmacol 52:821-828.
37. Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-35.
38. Sadja R, Alagem N, Reuveny E (2003) Gating of GIRK channels: details of an intricate, membrane-delimited signaling complex. Neuron 39:9-12.
39. + channel. J Cell Biol 135:1619-1632.
40. Shaw G, Morse S, Ararat M, Graham FL (2002) Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J 16:869-871.
41. + channels expressed in transfected mammalian cells. J Biol Chem 269:23204-23211.
42. Surmeier DJ, Foehring R (2004) A mechanism for homeostatic plasticity. Nat Neurosci 7:691-692.
43. 2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine. Biochem J 343:39-44.
44. + channel polypeptide in rat brain. Proc Natl Acad Sci USA 88:10764-10768.
45. + channel isoforms in the developing rat brain. FEBS Lett 324:205-210.
46. Trimmer JS, Rhodes KJ (2004) Localization of voltage-gated ion channels in mammalian brain. Annu Rev Physiol 66:477-519.
47. + channel function by deletions at the N- and C-termini. Neuron 5:433-443.
48. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-1893.
49. Yuste R, Lanni F, Konnerth A (2000) Imaging neurons: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.