Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer

Pathology International

Volumn 56, Issue 9, 2006, Pages 503-509

  Jung, Chan Kwon ^a   Jung, Ji Han ^a   Park, Gyeong Sin ^a   Lee, Ahwon ^a   Kang, Chang Suk ^a   Lee, Kyo Young ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Histochemistry; Lung cancer; p53; Prognosis; TACC3

Indexed keywords

GENE PRODUCT; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PROTEIN P53; TRANSFORMING ACIDIC COILED COIL CONTAINING PROTEIN 3; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; SURVIVAL TIME; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; PROGNOSIS; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33747477095     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2006.01998.x     Document Type: Article

References (21)

1. Gergely F. Centrosomal TACCtics. Bioessays 2002; 24: 915-25.
2. Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Oncogene 1999; 18: 4032-8.
3. Still IH, Vince P, Cowell JK. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics 1999; 58: 165-70.
4. Dhanasekaran SM, Barrette TR, Ghosh D et al. Delineation of prognostic biomarkers in prostate cancer. Nature 2001; 412: 822-6.
5. Chen HM, Schmeichel KL, Mian IS, Lelievre S, Petersen OW, Bissell MJ. AZU-1: A candidate breast tumor suppressor and biomarker for tumor progression. Mol Biol Cell 2000; 11: 1357-67.
6. Schuendeln MM, Piekorz RP, Wichmann C et al. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol 2004; 24: 6403-9.
7. Piekorz RP, Hoffmeyer A, Duntsch CD et al. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J 2002; 21: 653-64.
8. Raff JW. Centrosomes and cancer: Lessons from a TACC. Trends Cell Biol 2002; 12: 222-5.
9. Pihan GA, Purohit A, Wallace J et al. Centrosome defects and genetic instability in malignant tumors. Cancer Res 1998; 58: 3974-85.
10. Sadek CM, Pelto-Huikko M, Tujague M, Steffensen KR, Wennerholm M, Gustafsson JA. TACC3 expression is tightly regulated during early differentiation. Gene Expr Patterns 2003; 3: 203-11.
11. Lauffart B, Vaughan MM, Eddy R et al. Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC Womens Health 2005; 5: 8.
12. Conte N, Charafe-Jauffret E, Delaval B et al. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Oncogene 2002; 21: 5619-30.
13. Ma XJ, Salunga R, Tuggle JT et al. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 2003; 100: 5974-9.
14. O'Connell MJ, Walworth NC, Carr AM. The G2-phase DNA-damage checkpoint. Trends Cell Biol 2000; 10: 296-303.
15. Harris CC. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996; 88: 1442-55.
16. Cordon-Cardo C, Dalbagni G, Saez GT et al. p53 mutations in human bladder cancer: Genotypic versus phenotypic patterns. Int J Cancer 1994; 56: 347-53.
17. Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc Natl Acad Sci USA 2000; 97: 14 352-7.
18. Sadek CM, Jalaguier S, Feeney EP et al. Isolation and characterization of AINT: A novel ARNT interacting protein expressed during murine embryonic development. Mech Dev 2000; 97: 13-26.
19. Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. BMC Evol Biol 2004; 4: 16.
20. Garriga-Canut M, Orkin SH. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J Biol Chem 2004; 279: 23 597-605.
21. Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Oncogene 2004; 23: 2559-63.