A role of PPAR-γ in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage

Annals of Surgery

Volumn 244, Issue 1, 2006, Pages 131-138

  Shimizu, Tomoharu ^a   Szalay, László ^a   Hsieh, Ya Ching ^a   Suzuki, Takao ^a   Choudhry, Mashkoor A ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a,b  

^a Kentucky   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; ANDROSTENEDIOL; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RINGER LACTATE SOLUTION; 2-CHLORO-5-NITROBENZANILIDE; 9-DEOXY-DELTA-9-PROSTAGLANDIN D2; ANABOLIC AGENT; ANILIDE; DRUG DERIVATIVE; PROSTAGLANDIN D2; PROSTAGLANDIN J2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BLEEDING; BLOOD VOLUME; BODY WEIGHT; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; HEART FUNCTION TEST; HEMORRHAGIC SHOCK; INJURY; LAPAROTOMY; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; RESUSCITATION; ANIMAL; BLOOD; DRUG ANTAGONISM; DRUG POTENTIATION; GEL MOBILITY SHIFT ASSAY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART OUTPUT; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANABOLIC AGENTS; ANDROSTENEDIOL; ANILIDES; ANIMALS; BLOTTING, WESTERN; CARDIAC OUTPUT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; INTERLEUKIN-6; MALE; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; PPAR GAMMA; PROSTAGLANDIN D2; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; VENTRICULAR FUNCTION, LEFT;

EID: 33747465130     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sla.0000217709.00863.82     Document Type: Article

References (46)

1. Ba ZF, Wang P, Koo DJ, et al. Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med. 2000;28:2837-2842.
2. Ayala A, Ertel W, Chaudry IH. Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock. 1996;5:79-90.
3. Jarrar D, Chaudry IH, Wang P. Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches [Review]. Int J Mol Med. 1999;4:575-583.
4. Diodato MD, Knoferl MW, Schwacha MG, et al. Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. Cytokine. 2001;14:162-169.
5. Angele MK, Schwacha MG, Ayala A, et al. Effect of gender and sex hormones on immune responses following shock. Shock. 2000;14:81-90.
6. Kuebler JF, Jarrar D, Bland KI, et al. Progesterone administration after trauma and hemorrhagic shock improves cardiovascular responses. Crit Care Med. 2003;31:1786-1793.
7. Roumen RM, Hendriks T, van der Ven-Jongekrijg J, et al. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma: relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg. 1993;218:769-776.
8. Akira S, Hirano T, Taga T, et al. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990;4:2860-2867.
9. Simpson RJ, Hammacher A, Smith DK, et al. Interleukin-6: structure-function relationships. Protein Sci. 1997;6:929-955.
10. Ancey C, Corbi P, Froger J, et al. Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture. Cytokine. 2002;18:199-205.
11. Yu X, Kennedy RH, Liu SJ. JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. J Biol Chem. 2003;278:16304-16309.
12. Finkel MS, Oddis CV, Jacob TD, et al. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 1992;257:387-389.
13. Jarrar D, Wang P, Song GY, et al. Metoclopramide: a novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage. Am J Physiol Endocrinol Metab. 2000;278:E90-E95.
14. Jarrar D, Wang P, Song GY, et al. Inhibition of tyrosine kinase signaling after trauma-hemorrhage: a novel approach for improving organ function and decreasing susceptibility to subsequent sepsis. Ann Surg. 2000;231:399-407.
15. Mizushima Y, Wang P, Jarrar D, et al. Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals. Ann Surg. 2000;232:673-679.
16. Yang S, Zheng R, Hu S, et al. Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function. Am J Physiol Heart Circ Physiol. 2004;287:H2183-H2191.
17. Toth B, Yokoyama Y, Schwacha MG, et al. Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock. J Appl Physiol. 2004;97:2184-2189.
18. Blanquart C, Barbier O, Fruchart JC, et al. Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol. 2003;85:267-273.
19. Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res. 2000;49:497-505.
20. Abdelrahman M, Collin M, Thiemermann C. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. Shock. 2004;22:555-561.
21. Collin M, Abdelrahman M, Thiemermann C. Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock. Eur J Pharmacol. 2004;486:233-235.
22. Zingarelli B, Cook JA. Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock. 2005;23:393-399.
23. Wayman NS, Hattori Y, McDonald MC, et al. Ligands of the peroxisome proliferator activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J. 2002;16:1027-1040.
24. Yue Tl TL, Chen J, Bao W, et al. In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation. 2001;104:2588-2594.
25. Ben Nathan D, Padgett DA, Loria RM. Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity. J Med Microbiol. 1999;48:425-431.
26. Shimizu T, Choudhry MA, Szalay L, et al. Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage. Am J Physiol Regul Integr Comp Physiol. 2004;287:R386-R390.
27. Waxman DJ. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. J Endocrinol. 1996;150(suppl):129-147.
28. Schreiber E, Matthias P, Muller MM, et al. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells. Nucleic Acids Res. 1989;17:6419.
29. Shimizu T, Szalay L, Choudhry MA, et al. Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase. Am J Physiol Gastrointest Liver Physiol. 2005;288:G244-G250.
30. Collin M, Patel NS, Dugo L, et al. Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxy-delta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. Crit Care Med. 2004;32:826-831.
31. Cuzzocrea S, Pisano B, Dugo L, et al. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. Eur J Pharmacol. 2004;483:79-93.
32. Kitamura Y, Kakimura J, Matsuoka Y, et al. Activators of peroxisome proliferator activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neurosci Lett. 1999;262:129-132.
33. Uchimura K, Nakamuta M, Enjoji M, et al. Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Hepatology. 2001;33:91-99.
34. Liu HR, Tao L, Gao E, et al. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. Cardiovasc Res. 2004;62:135-144.
35. Hierholzer C, Billiar TR. Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg. 2001;386:302-308.
36. Murphy KD, Lee JO, Herndon DN. Current pharmacotherapy for the treatment of severe burns. Expert Opin Pharmacother. 2003;4:369-384.
37. Jambrik Z, Gyongyosi M, Hegyi P, et al. Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits. Intensive Care Med. 2002;28:1810-1818.
38. Maass DL, White J, Horton JW. IL-1beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma. Shock. 2002;18:360-366.
39. Shah AM, Prendergast BD, Grocott-Mason R, et al. The influence of endothelium-derived nitric oxide on myocardial contractile function. Int J Cardiol. 1995;50:225-231.
40. Tatsumi T, Matoba S, Kawahara A, et al. Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes. J Am Coll Cardiol. 2000;35:1338-1346.
41. Ungureanu-Longrois D, Balligand JL, Kelly RA, et al. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes. J Mol Cell Cardiol. 1995;27:155-167.
42. Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000;403:103-108.
43. Forman BM, Tontonoz P, Chen J, et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 1995;83:803-812.
44. Jarrar D, Song GY, Kuebler JF, et al. The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels. Arch Surg. 2004;139:896-901.
45. Lazennec G, Canaple L, Saugy D, et al. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol Endocrinol. 2000;14:1962-1975.
46. Yoshimata T, Yoneyama A, Jin-no Y, et al. Effects of dehydroepiandrosterone on mitogen-activated protein kinase in human aortic smooth muscle cells. Life Sci. 1999;65:431-440.