A pseudosymmetric cell adhesion regulatory domain in the β7 tail of the integrin α4β7 that interacts with focal adhesion kinase and src

European Journal of Immunology

Volumn 36, Issue 8, 2006, Pages 2203-2214

  Krissansen, Geoffrey W ^a   Singh, Jaison ^a   Kanwar, Rupinder K ^a   Chan, Yih Chih ^a   Leung, Euphemia ^a   Lenhert, Klaus B ^a   Kanwar, Jagat R ^a   Yang, Yi ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

7 integrin; Cell adhesion regulatory domain; Kinases; Signal transduction; T cells

Indexed keywords

ALPHA4 INTEGRIN; AMINO ACID; ANTIINFLAMMATORY AGENT; ARGININE; ASPARTIC ACID; BETA7 INTEGRIN; CYTOSKELETON PROTEIN; FOCAL ADHESION KINASE; GLUTAMIC ACID; LIGAND; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; MUTANT PROTEIN; PALINDROMIC DNA; PHENYLALANINE; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; TYROSINE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CHRONIC INFLAMMATION; CLUSTER ANALYSIS; CONTROLLED STUDY; CYTOPLASM; ENANTIOMER; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; IMMUNOMODULATION; IMMUNOREGULATION; INFLAMMATORY DISEASE; LEUKOCYTE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; CELL ADHESION; CELL LINE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRINS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); T-LYMPHOCYTES;

EID: 33747426294     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535324     Document Type: Article

References (49)

1. Krissansen, G. W., Integrin superfamily. The Encyclopedia of Life Sciences, MacMillan Press, London, UK 2000.
2. Yauch, R. L., Felsenfeld, D. P., Kraeft, S-K., Chen, L. B., Sheetz, M. P. and Hemler, M. E., Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J. Exp. Med. 1997 186: 1347-1355.
3. Jakubowski, A., Rosa, M. D., Bixler, S., Lobb, R. and Burkly, L. C., Vascular cell adhesion molecule (VCAM)-Ig fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor. Cell Adhes. Commun. 1995. 3: 131-142.
4. Zhang, Z., Vuori, K. Wang, H-G., Reed, J. C., and Ruoslahti, E., Integrin activation by R-ras. Cell 1996. 85: 61-69.
5. D'Souza-Schorey, C., Boettner, B. and van Aelst, L., Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell. Biol. 1998. 18: 3936-3946.
6. Hughes, P. E. and Pfaff, M., Integrin affinity modulation. Trends Cell Biol. 1998. 8: 359-364.
7. Krissansen, G. W. and Danen, E.J.H., Integrins: Signaling and disease. The Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, UK. 2000.
8. Van Kooyk, Y. and Figdor, C. G., Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol. 2000. 12: 542-547.
9. Zhang, V. W., Yang, Y., Berg, R. W., Leung, E., Hall, A. and Krissansen, G.W., The small GTP binding proteins Rho and Rac induce lymphocyte adhesion to the mucosal addressin MAdCAM-1 in a hierarchical fashion. Eur. J. Immunol. 1999. 29: 2875-2885.
10. Dormond, O., Ponsonnet, L., Hasmim, M., Foletti, A. and Ruegg, C., Manganese-induced integrin affinity maturation promotes recruitment of alpha V beta 3 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src. Thromb. Haemost. 2004. 92: 151-161.
11. Hamann, A., Andrew, D. P., Jablonski-Westrich, B., Holzmann, B. and Butcher, E. C., The role of α4 integrins in lymphocyte homing to mucosal tissues in vivo. J. Immunol. 1994. 152: 3282-3293.
12. Wagner, N., Lohler, J., Kunkel, E. J., Ley, K., Leung, E., Krissansen, G. and Mueller, W., Critical role for β7 integrins; in the formation of the gut associated lymphoid tissue. Nature 1996. 382: 366-370.
13. Yang, X., Sytwn, H-K., McDevitt, H.O. and Michie, S. A., Involvement of β7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in nonobese diabetic mice. Diabetes 1997. 46: 1542-1547.
14. Kanwar, J. R., Harrison, J. E. B., Wang, D., Leung, E., Wagner, N., Mueller, W. and Krissansen, G. W., Contributory role for β7 integrins in non-remitting experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2000. 103: 146-152.
15. Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., Weissman, I. L. et al., α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993. 74: 185-195.
16. Kanwar, J. R., Wang, D. and Krissansen, G. W., Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against MAdCAM-1, given early in the course of disease progression. Immunol. Cell Biol. 2000. 78: 641-646.
17. Yang, Y., Harrison, J. E. B., Print, C. G., Lehnert, K., Sammar, M., Lazarovits, A. and Krissansen, G. W., Interaction of monocytoid cells with the mucosal addressin MAdCAM-1 via the integrins VLA-4 and LPAM-1. Immunol. Cell Biol. 1996. 74: 383-393.
18. Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L. and Brenner, M. B., Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin. Nature 1994. 372: 190-193.
19. Karecla, P. I, Bowden, S. J., Green, S. J. and Kilshaw, P. J., Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin αM290β7 (αEβ7). Eur. J. Immunol. 1995. 25: 852-856.
20. Fagerholm, S. C., Hilden, T. J. and Gahmberg, C. G., P marks the spot: site-specific integrin phosphorylation regulates molecular interactions. Trends Biochem. Sci. 2004. 29: 504-512.
21. Cowan, K. J., Law, D. A. and Phillips, D. R., Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta3 during outside-in integrin platelet signaling. J. Biol. Chem. 2000. 275: 36423-36429.
22. Hibbs, M. L., Jakes, S., Stacker, S. A., Wallace, R. W. and Springer, T. A., The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site. J. Exp. Med. 1991. 174: 1227-1238.
23. Mulrooney, J., Foley, K., Vineberg, S., Barreuther, M. and Grabel, L., Phosphorylation of the beta 1 integrin cytoplasmic domain: toward an understanding of function and mechanism. Exp. Cell Res.. 258: 332-341.
24. Rietzler, M., Bittner, M., Kolanus, W., Schuster, A. and Holzmann, B., The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of β7-integrins. J. Biol. Chem. 1998. 273: 27459-27466.
25. Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G. and Prochiantz, A., Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J. Biol. Chem. 1996. 271: 18188-18193.
26. Prochiantz, A., Getting hydrophilic compounds into cells: lessons from homeopeptides. Curr. Opinion Neurobiol. 1996. 6: 629-634.
27. Liu, X-Y., Timmons, S., Lin, Y-Z. and Hawiger, J., Identification of functionally important sequence in the cytoplasmic tail of integrin β3 by using cell-permeable peptide analogs. Proc. Natl. Acad. USA 1996. 93: 11819-11824.
28. Mitchell, D. J., Kim, D. T., Steinman, L., Fathman, C. G. and Rothbard, J. B., Polyarginine enters cells more efficiently than other polycationic homopolymers. J. Pept. Res. 2000. 56: 318-325.
29. Schlaepfer, D. D., Hauck, C. R. and Sieg, D. J., Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 1999. 71: 435-478.
30. Songyang, Z., Carraway, K. L., Eck, M. J., Harrison, S. C., Feldman, R. A., Mohammodi, M., Schlessinger, J. et al., Catalytic specificity of protein-tyrosine kinases is critical for selective signaling. Nature 1995. 373: 536-539.
31. Hughes, P. E., Diazgonzalez, F., Leong, L., Wu, C. Y., McDonald, J. A., Shattil, S. J. and Ginsberg, M. H., Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J. Biol. Chem. 1996. 271: 6571-6574.
32. Bleijs, D. A., Van Duijnhoven, G. C. F., Van Vliet, S. J., Thijssen, J. P. H., Figdor, C. G. and Van Kooyk, Y., A single amino acid in the cytoplasmic domain of the β2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling. J. Biol. Chem. 2001. 276: 10338-10346.
33. Isakov, N., Wange, R. L., Burgess, W. H., Watts, J. D., Aebersold, R. and Sarnelson, L. E., ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J. Exp. Med. 1995. 181: 375-380.
34. Akiyama, S. K., Yamada, S. S., Yamada, K. M. and LaFlamme, S. E., Transmembrane signal transduction by integrin cytoplasmic domains expressed in single -subunit chimeras. J. Biol. Chem. 1994. 269: 15961-15964.
35. Chen, Y., O'Toole, T. E., Ylanne, J., Rosa, J. and Ginsberg, M. H., A point mutation in the integrin β3 cytoplasmic domain (S752-P) impairs bidirectional signaling through αIIbβ3 (platelet glycoprotein IIb-IIIa). Blood 1994. 84: 1857-1865.
36. LaFlamme, S. E., Akiyama, S. K. and Yamada, K. M., Regulation of fibronectin receptor distribution. J. Cell Biol. 1992. 117: 437-447.
37. Lukashev, M. E., Sheppard, D. and Pytela, R., Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain. J. Biol. Chem. 1994. 269: 18311-18314.
38. Zent, R., Fenczik, C. A., Calderwood, D. A., Liu, S., Dellos, M. and Ginsberg, M. H., Class- and splice variant-specific association of CD98 with integrin β cytoplasmic domains. J. Biol. Chem. 2000. 275: 5059-5064.
39. Liu, S., Calderwood, D. A. and Ginsberg, M. H., Integrin cytoplasmic domain-binding proteins. J. Cell Sci. 2000. 113: 3563-3571.
40. Pfaff, M., Liu, S., Erle, D. J. and Ginsberg, M. H., Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins. J. Biol. Chem. 1998. 273: 6104-6109.
41. Sharma, C. P., Ezzell, R. M. and Arnaout, M. A., Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J. Immunol. 1995. 154: 3461-3470.
42. Loo, D. T., Kanner, S. B. and Aruffo, A., Filamin binds to the cytoplasmic domain of the β1-integrin. Identification of amino acids responsible for this interaction. J. Biol. Chem. 1998. 273: 23304-23312.
43. Campbell, I. D. and Ginsberg, M. H., The talin-tail interaction places integrin activation on FERM ground. Trends Biochem. Sci. 2004. 8: 429-435.
44. Garcia-Alvarez, B., de Pereda, J. M., Calderwood, D. A., Ulmer, T. S., Critchley, D., Campbell, I. D., Ginsberg, M. H. and Liddington, R. C., Structural determinants of integrin recognition by talin. Mol. Cell. 2003. 11: 49-58.
45. Schaller, M. D., Otey, C. A., Hildebrand, J. D. and Parsons, J. T., Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J. Cell Biol. 1995. 130: 1181-1187.
46. Arias-Salgado, E. G., Lizano, S., Sarkar, S., Brugge, J. S., Ginsberg, M. H., and Shattil, S. J., Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. USA 2003. 100: 13298-13302.
47. Braun, S., Raymond, W. E. and Racker, E., Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases. J. Biol. Chem. 1984. 259: 2051-2054.
48. Yang, Y., Sammar, M., Harrison, J. E. B., Lehnert, K., Print, C. G., Leung, E., Prestidge, R. and Krissansen, G. W., Construction and adhesive properties of a soluble MAdCAM-1-Fc chimera expressed in a baculovirus system: phylogenetic conservation of receptor-ligand interaction. Scand. J. Immunol. 1995. 42: 235-247.
49. Lehnert, K., Print, C. G., Yang, Y. and Krissansen, G. W., Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) costimulates T cell proliferation exclusively through integrin α4β7 (LPAM-1), whereas VCAM-1 and CS-1 peptide use α4β1 (VLA-4): Evidence for "remote" costimulation and induction of hyperresponsiveness to B7 molecules. Eur. J. Immunol. 1998. 28: 3605-3615.