The natural and molecular history of Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 9, Issue SUPPL. 3, 2006, Pages 187-194

  Delacourte, André ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; TAU PROTEIN;

AGED; AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DEMENTIA; DISEASE COURSE; ENTORHINAL CORTEX; HIPPOCAMPUS; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; TEMPORAL CORTEX;

EID: 33747409457     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2006-9s322     Document Type: Review

References (46)

1. W. Hartig, C. Klein, K. Brauer, K.F. Schuppel, T. Arendt, G. Bruckner et al., Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders, Acta Neuropathol (Berl) 100(3) (2000), 305-312.
2. C. Schultz, G.B. Hubbard, U. Rub, E. Braak and H. Braak, Age-related progression of tau pathology in brains of baboons, Neurobiology of Aging 21(6) (2000), 905-912.
3. G.G. Glenner and C.W. Wong, Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein, Biochem Biophys Res Commun 122(3) (1984), 1131-1135.
4. J.A. Hardy and G.A. Higgins, Alzheimer's disease: the amyloid cascade hypothesis, Science 256(5054) (1992), 184-185.
5. R. Sherrington, E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda et al., Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature 375(6534) (1995), 754-760.
6. K. Duff, C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Perez-tur et al., Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1, Nature 383(6602) (1996), 710-713.
7. H. Braak and E. Braak, Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis, Acta Neuropathol (Berl) 92(2) (1996), 197-201.
8. H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol 82(4) (1991), 239-259.
9. B.T. Hyman and J.Q. Trojanowski, Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease, J Neuropathol Exp Neurol 56(10) (1997), 1095-1097.
10. A. Delacourte and A. Defossez, Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments, J Neurol Sci 76(2-3) (1986), 173-186.
11. J.P. Brion, A.M. Couck, E. Passareiro and J. Flament-Durand, Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study, J Submicrosc Cytol 17(1) (1985), 89-96.
12. I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski and L.I. Binder, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc Natl Acad Sci USA 83(13) (1986), 4913-4917.
13. S. Flament, A. Delacourte, B. Hemon and A. Defossez, Characterization of two pathological tau protein variants in Alzheimer brain cortices, J Neurol Sci 92(2-3) (1989), 133-141.
14. A. Delacourte, S. Flament, E.M. Dibe, P. Hublau, B. Sablonniere, B. Hemon et al., Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins, Acta Neuropathol 80(2) (1990), 111-117.
15. S. Flament and A. Delacourte, Tau marker? Nature 346(6279) (1990), 22.
16. J.H. Lee, B.J. Balin, L. Otvos and J.Q. Trqjanowski, A68: a major subunit of paired helical filaments and derivatized forms of normal Tau, Science (1991).
17. M. Goedert, M.G. Spillantini, N.J. Cairns and R.A. Crowther, Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms, Neuron 8(1) (1992), 159-168.
18. N. Sergeant, J.P. David, M. Goedert, R. Jakes, P. Vermersch, L. Buee et al., Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications, J Neurochem 69(2) (1997), 834-844.
19. S. Flament, A. Delacourte, M. Verny, J.J. Hauw and F. Javoy-Agid, Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type, Acta Neuropathol 81(6) (1991), 591-596.
20. N. Sergeant, A. Wattez and A. Delacourte, Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms, J Neurochem 72(3) (1999), 1243-1249.
21. A. Delacourte, Y. Robitaille, N. Sergeant, L. Buee, P.R. Hof, A. Wattez et al., Specific pathological Tau protein variants characterize Pick's disease, J Neuropathol Exp Neurol 55(2) (1996), 159-168.
22. A. Delacourte, N. Sergeant, A. Wattez, D. Gauvreau and Y. Robitaille, Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation, Ann Neurol 43(2) (1998), 193-204.
23. P. Vermersch, N. Sergeant, M.M. Ruchoux, H. Hofmann-Radvanyi, A. Wattez, H. Petit et al., Specific tau variants in the brains of patients with myotonic dystrophy, Neurology 47(3) (1996), 711-717.
24. N. Sergeant, B. Sablonniere, S. Schraen-Maschke, A. Ghestem, C.A. Maurage, A. Wattez et al., Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1, Hum Mol Genet 10(19) (2001), 2143-2155.
25. P. Vermersch, R. Bordet, F. Ledoze, M.M. Ruchoux, F. Chapon, P. Thomas et al., Demonstration of a specific profile of pathological Tau proteins in frontotemporal dementia cases, C R Acad Sci III 318(4) (1995), 439-445.
26. V. Zhukareva, V. Vogelsberg-Ragaglia, V.M. Van Deerlin, J. Bruce, T. Shuck, M. Grossman et al., Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia, Ann Neurol 49(2) (2001), 165-175.
27. M. Goedert and M.G. Spillantini, Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease, Biochim Biophys Acta 1502(1) (2000), 110-121.
28. A. Delacourte, J.P. David, N. Sergeant, L. Buee, A. Wattez, P. Vermersch et al., The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease, Neurology 52 (1999), 1158-1165.
29. A. Delacourte, N. Sergeant, D. Champain, A. Wattez, C.A. Maurage, F. Lebert et al., Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease, Neurology 59(3) (2002), 398-407.
30. A.L. Guillozet, S. Weintraub, D.C. Mash and M.M. Mesulam, Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment, Arch Neurol 60(5) (2003), 729-736.
31. K. Blennow, CSF biomarkers for mild cognitive impairment, J Intern Med 256(3) (2004), 224-234.
32. A. Delacourte, The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease, Neurology 54 (2000), 538.
33. H. Braak and E. Braak, Frequency of stages of Alzheimer-related lesions in different age categories, Neurobiol Aging 18(4) (1997), 351-357.
34. N. Sergeant, S. Bombois, A. Ghestem, H. Drobecq, V. Kostanjevecki, C. Missiaen et al., Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach, J Neurochem 85 (2003), 1581-1591.
35. P.R. Turner, K. O'Connor, W.P. Tate and W.C. Abraham, Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory, Prog Neurobiol 70(1) (2003), 1-32.
36. N. Sergeant, J.P. David, D. Champain, A. Ghestem, A. Wattez and A. Delacourte, Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease, J Neurochem 81(4) (2002), 663-672.
37. X. Cao and T.C. Sudhof, Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation, J Biol Chem 279(23) (2004), 24601-24611.
38. R.L. Neve and N.K. Robakis, Alzheimer's disease: a reexamination of the amyloid hypothesis, Trends Neurosci 21(1) (1998), 15-19.
39. R.L. Neve, A beta may be a planet, but APP is central, Neurobiology of Aging 22(1) (2001), 151-154.
40. H.G. Lee, G. Casadesus, X. Zhu, A. Takeda, G. Perry and M.A. Smith, Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease, Ann N Y Acad Sci 1019 (2004), 1-4.
41. J. Gotz, F. Chen, J. van Dorpe and R.M. Nitsch, Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils, Science 293(5534) (2001), 1491-1495.
42. J. Lewis, D.W. Dickson, W.L. Lin, L. Chisholm, A. Corral, G. Jones et al., Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP, Science 293(5534) (2001), 1487-1491.
43. C. Casas, N. Sergeant, J.M. Itier, V. Blanchard, O. Wirths, N. van der Kolk et al., Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model, Am J Pathol 165(4) (2004), 1289-1300.
44. M.G. Spillantini, J.R. Murrell, M. Goedert, M.R. Farlow, A. Klug and B. Ghetti, Mutation in the tau gene in familial multiple system tauopathy with presenile dementia, Proc Natl Acad Sci USA 95(13) (1998), 7737-7741.
45. M. Baker, I. Litvan, H. Houlden, J. Adamson, D. Dickson, J. Perez-Tur et al., Association of an extended haplotype in the tau gene with progressive supranuclear palsy, Hum Mol Genet 8(4) (1999), 711-715.
46. A. Delacourte, N. Sergeant, A. Wattez, C.A. Maurage, F. Lebert, F. Pasquier et al., Tau aggregation in the hippocampal formation: an ageing or a pathological process? Exp Gerontol 37(10-11) (2002), 1291-1296.