Repetitive exposure to TGF-β suppresses TGF-β type I receptor expression by differentiated osteoblasts

Gene

Volumn 379, Issue 1-2, 2006, Pages 175-184

  Kim, Kenneth K ^a   Ji, Changhua ^a   Chang, Weizhong ^a   Wells, Rebecca G ^b   Gundberg, Caren M ^a   McCarthy, Thomas L ^a   Centrella, Michael ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bone; Gene promoter; Runx; Transcription

Indexed keywords

TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL CELL; ARTICLE; BINDING SITE; BONE GROWTH; BONE REMODELING; CELL DIFFERENTIATION; CHROMATIN; FEEDBACK SYSTEM; FETUS; GENE EXPRESSION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELL DIFFERENTIATION; CELL NUCLEUS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33747353610     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2006.05.005     Document Type: Article

References (55)

1. Alliston T., Choy L., Ducy P., Karsenty G., and Derynck R. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 20 (2001) 2254-2272
2. Bascom C.C., et al. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol. Cell. Biol. 9 (1989) 5508-5515
3. Carpenter T.O., et al. Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice. Endocrinology 139 (1998) 35-43
4. Centrella M., McCarthy T.L., and Canalis E. Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J. Biol. Chem. 262 (1987) 2869-2874
5. Centrella M., McCarthy T.L., and Canalis E. Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 5889-5893
6. Centrella M., McCarthy T.L., and Canalis E. Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone. Mol. Cell. Biol. 11 (1991) 4490-4496
7. Centrella M., Casinghino S., Ignotz R., and McCarthy T.L. Multiple regulatory effects by transforming growth factor-beta on type I collagen levels in osteoblast-enriched cultures from fetal rat bone. Endocrinology 131 (1992) 2863-2872
8. Centrella M., Casinghino S., and McCarthy T.L. Differential actions of prostaglandins in separate cell populations from fetal rat bone. Endocrinology 135 (1994) 1611-1620
9. Centrella M., Horowitz M.C., Wozney J.M., and McCarthy T.L. Transforming growth factor-beta gene family members and bone. Endocr. Rev. 15 (1994) 27-39
10. Centrella M., et al. Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol. Cell. Biol. 15 (1995) 3273-3281
11. Centrella M., Casinghino S., Gundberg C., McCarthy T.L., Wozney J., and Rosen V. Changes in bone morphogenetic protein sensitivity relative to differentiation in fetal rat bone cell cultures. Ann. N.Y. Acad. Sci. 785 (1996) 224-226
12. Centrella M., Ji C., Casinghino S., and McCarthy T.L. Rapid flux in transforming growth factor-beta receptors on bone cells. J. Biol. Chem. 271 (1996) 18616-18622
13. Centrella M., Rosen V., Wozney J.M., Casinghino S.R., and McCarthy T.L. Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures. J. Cell. Biochem. 67 (1997) 528-540
14. Chang D.J., Ji C., Kim K.K., Casinghino S., McCarthy T.L., and Centrella M. Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid. J. Biol. Chem. 273 (1998) 4892-4896
15. Chang W., et al. Transcriptional and post-transcriptional regulation of transforming growth factor beta type II receptor expression in osteoblasts. Gene 299 (2002) 65-77
16. Dallas S.L., Park-Snyder S., Miyazono K., Twardzik D., Mundy G.R., and Bonewald L.F. Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. J. Biol. Chem. 269 (1994) 6815-6821
17. Di Guglielmo G.M., Le Roy C., Goodfellow A.F., and Wrana J.L. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat. Cell Biol. 5 (2003) 410-421
18. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
19. Eickelberg O., Centrella M., Reiss M., Kashgarian M., and Wells R.G. Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation: glycosaminoglycan modifications alter betaglycan function. J. Biol. Chem. 277 (2002) 823-829
20. Erlebacher A., and Derynck R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J. Cell Biol. 132 (1996) 195-210
21. Filvaroff E., et al. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development 126 (1999) 4267-4279
22. Fromigue O., Marie P.J., and Lomri A. Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. J. Cell. Biochem. 68 (1998) 411-426
23. Harris S.E., et al. Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J. Bone Miner. Res. 9 (1994) 855-863
24. Hefferan T.E., et al. Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. J. Biol. Chem. 275 (2000) 20255-20259
25. Im H., Grass J.A., Johnson K.D., Boyer M.E., Wu J., and Bresnick E.H. Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Method Mol. Biol. 284 (2004) 129-146
26. Jay P.R., Centrella M., Lorenzo J., Bruce A.G., and Horowitz M.C. Oncostatin-M: a new bone active cytokine that activates osteoblasts and inhibits bone resorption. Endocrinology 137 (1996) 1151-1158
27. Ji C., Casinghino S., McCarthy T.L., and Centrella M. Cloning, characterization, and expression of the transforming growth factor-beta type I receptor promoter in fetal rat bone cells. J. Cell. Biochem. 63 (1996) 478-490
28. Ji C., Casinghino S., McCarthy T.L., and Centrella M. Multiple and essential Sp1 binding sites in the promoter for transforming growth factor-beta type I receptor. J. Biol. Chem. 272 (1997) 21260-21267
29. Ji C., et al. CBFa(AML/PEBP2)-related elements in the TGF-beta type I receptor promoter and expression with osteoblast differentiation. J. Cell. Biochem. 69 (1998) 353-363
30. Ji C., Chen Y., McCarthy T.L., and Centrella M. Cloning the promoter for transforming growth factor-beta type III receptor. Basal and conditional expression in fetal rat osteoblasts. J. Biol. Chem. 274 (1999) 30487-30494
31. Ji C., Eickelberg O., McCarthy T.L., and Centrella M. Control and counter-control of TGF-beta activity through FAST and Runx (CBFa) transcriptional elements in osteoblasts. Endocrinology 142 (2001) 3873-3879
32. Kim S.J., et al. Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction. Ann. N.Y. Acad. Sci. 593 (1990) 43-50
33. Komori T., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
34. Lian J.B., and Stein G.S. Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation. Iowa Orthop. J. 15 (1995) 118-140
35. Lian J.B., et al. Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Conn. Tiss. Res. 44 Suppl. 1 (2003) 141-148
36. Lieb E., Vogel T., Milz S., Dauner M., and Schulz M.B. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: osteoblastic differentiation. Tissue Eng. 10 (2004) 1414-1425
37. Lilli C., et al. Biomembranes enriched with TGFbeta1 favor bone matrix protein expression by human osteoblasts in vitro. J. Biomed. Mater. Res. 63 (2002) 577-582
38. McCarthy T.L., Centrella M., and Canalis E. Further biochemical and molecular characterization of primary rat parietal bone cell cultures. J. Bone Miner. Res. 3 (1988) 401-408
39. McCarthy T.L., et al. Runt domain factor (Runx)-dependent effects on CCAAT/ enhancer-binding protein delta expression and activity in osteoblasts. J. Biol. Chem. 275 (2000) 21746-21753
40. McCarthy T.L., Chang W.-Z., Liu Y., and Centrella M. Runx2 integrates estrogen activity in osteoblasts. J. Biol. Chem. 278 (2003) 43121-43129
41. Miura M., et al. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J. Clin. Invest. 114 (2004) 1704-1713
42. Noda M. Transcriptional regulation of osteocalcin production by transforming growth factor-beta in rat osteoblast-like cells. Endocrinology 124 (1989) 612-617
43. Otto F., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 (1997) 765-771
44. Selvamurugan N., Pulumati M.R., Tyson D.R., and Partridge N.C. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J. Biol. Chem. 275 (2000) 5037-5042
45. Selvamurugan N., Kwok S., Alliston T., Reiss M., and Partridge N.C. Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. J. Biol. Chem. 279 (2004) 19327-19334
46. Shen R., et al. Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J. Biol. Chem. 281 (2006) 3569-3576
47. Spinella-Jaegle S., et al. Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone 29 (2001) 323-330
48. Staal A., et al. Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. Endocrinology 137 (1996) 2001-2011
49. Takagi M., et al. Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells. J. Mol. Histol. 35 (2004) 81-90
50. Varghese S., Rydziel S., and Canalis E. Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. J. Cell. Physiol. 202 (2005) 391-399
51. Viereck V., Siggelkow H., Tauber S., Raddatz D., Schutze N., and Hufner M. Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin-D3, dexamethasone, and local growth factors in primary human osteoblasts. J. Cell. Biochem. 86 (2002) 348-356
52. Wrana J.L. TGF-beta receptors and signalling mechanisms. Miner. Electrolyte Metab. 24 (1998) 120-130
53. Wrana J.L., et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71 (1992) 1003-1014
54. Zawel L., et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1 (1998) 611-617
55. Zhang H., Ahmad M., and Gronowicz G. Effects of transforming growth factor-beta 1 (TGF-beta1) on in vitro mineralization of human osteoblasts on implant materials. Biomaterials 24 (2003) 2013-2020