The importance of 293 cell cycle phase on adenovirus vector production

Enzyme and Microbial Technology

Volumn 39, Issue 6, 2006, Pages 1328-1332

  Zhang, Changhe ^a   Ferreira, Tiago B ^a   Cruz, Pedro E ^a   Alves, Paula M ^a   Haury, Matthias ^b   Carrondo, Manuel J T ^a,c  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

293 Cells; Adenovirus vector production; Cell cycle; Cell density effect

Indexed keywords

CELL CULTURE; GROWTH KINETICS; MICROBIOLOGY; VIRUSES;

ADENOVIRUS VECTOR PRODUCTION; CELL CYCLE; CELL DENSITY EFFECT;

CELLS;

ADENOVIRUS VECTOR;

ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CELL DENSITY; CELL FRACTIONATION; CELL GROWTH; CELL SPECIFICITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFECTION; NONHUMAN; NUTRIENT; PRODUCTIVITY; VOLUMETRY;

ADENOVIRIDAE;

EID: 33747341098     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2006.03.021     Document Type: Article

References (30)

1. Ferreira T.B., Alves P.M., Aunins J.G., and Carrondo M.J.T. Use of adenoviral vectors as veterinary vaccines. Gene Ther 12 Suppl. 1 (2005) S73-S83
2. Nadeau I., and Kamen A. Production of adenovirus vector for gene therapy. Biotechnol Adv 20 (2003) 475-489
3. Kamen A., and Henry O. Development and optimization of an adenovirus production process. J Gene Med 6 Suppl. 1 (2004) S184-S192
4. Henry O., Dormond E., Perrier M., and Kamen A. Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures. Biotechnol Bioeng 86 (2004) 765-774
5. Ferreira T.B., Ferreira A.L., Carrondo M.J.T., and Alves P.M. Effect of refeed strategies and non-ammoniagenic medium on adenovirus production at high cell densities. J Biotechnol 119 (2005) 272-280
6. Nadeau I., Jacob D., Perrier M., and Kamen A. 293SF metabolic flux analysis during cell growth and infection with an adenoviral vector. Biotechnol Prog 16 (2000) 872-884
7. Nadeau I., Sabatie J., Koehl M., Perrier M., and Kamen A. Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis. Metab Eng 2 (2000) 277-292
8. Nadeau I., Gilbert P.A., Jacob D., Perrier M., and Kamen A. Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus. Biotechnol Bioeng 77 (2002) 91-104
9. Garnier A., Cote J., Nadeau I., Kamen A., and Massie B. Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells. Cytotechnology 15 (1994) 145-155
10. Nadeau I., Garnier A., Côté J., Massie B., Chavarie C., and Kamen A. Improvement of recombinant protein production with human adenovirus/293S expression system using fed-batch strategies. Biotechnol Bioeng 51 (1996) 613-623
11. Cortin V., Thibault J., Jacob D., and Garnier A. High-titer adenovirus vector production in 293S cell perfusion culture. Biotechnol Prog 20 (2004) 858-863
12. Ferreira T.B., Ferreira A.L., Carrondo M.J.T., and Alves P.M. Two different serum-free media and osmolality effect upon 293 cell growth and adenovirus production. Biotechnol Lett 27 (2005) 1809-1813
13. Hodge L.D., and Scharff M.D. Effect of adenovirus on host cell DNA synthesis in synchronized cells. Virology 37 (1969) 554-564
14. Kraft V., and Tischer I. Cell cycle-dependent multiplication of avian adenoviruses in chicken embryo fibroblasts. Arch Virol 57 (1978) 243-254
15. Goodrum F.D., and Ornelles D.A. The early region 1B 55 kDa oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle. J Virol 71 (1997) 548-561
16. Feuer R., Mena I., Pagarigan R., Slifka M.K., and Whitton J.L. Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J Virol 76 (2002) 4430-4440
17. Wolter S., Richards R., and Armentrout R.W. Cell cycle-dependent replication of the DNA of Minute Virus of Mice, a Parvovirus. Biochim Biophys Acta 607 (1980) 420-431
18. Saito T., Dojima T., Toriyama M., and Park E.Y. The effect of cell cycle on GFPuv gene expression in the baculovirus expression system. J Biotechnol 93 (2002) 121-129
19. Vanderplasschen A., Goltz M., Lyaku J., Benarafa C., Buhk H.J., Thiry E., et al. The replication in-vitro of the gammaherpesvirus bovine herpesvirus-4 is restricted by its DNA-synthesis dependence on the S-phase of the cell-cycle. Virology 213 (1995) 328-340
20. Daksis J.I., and Preston C.M. Herpes simplex virus immediate early gene expression in the absence of transinduction by Vmw65 varies during the cell cycle. Virology 189 (1992) 196-202
21. Darling A.J., Boose J.A., and Spaltro J. Virus assay methods: accuracy and validation. Biologicals 26 (1998) 105-110
22. Vindelov L.L., Christensen I.J., Keiding N., Spang-Thomsen M., and Nissen N.I. Long-term storage of samples for flow cytometric DNA analysis. Cytometry 3 (1983) 317-322
23. Lullau E., Kanttinen A., Hassel J., Berg M., Haag-Alvarsson A., Cederbrant K., et al. Comparison of batch and perfusion culture in combination with pilot-scale expanded bed purification for the production of soluble recombinant beta-secretase. Biotechnol Prog 19 (2003) 37-44
24. Ramirez O.T., and Mutharasan R. Effect of serum on the plasma membrane fluidity of hybridomas: an insight into its shear protective mechanism. Biotechnol Prog 8 (1992) 40-50
25. Balcarcel R.R., and Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnol Bioeng 76 (2001) 1-10
26. Luo J., and Yang S.T. Effects of three-dimensional culturing in a fibrous matrix on cell cycle, apoptosis, and MAb production by hybridoma cells. Biotechnol Prog 20 (2004) 306-315
27. Ley K.D., and Tobey R.A. Regulation of initiation of DNA synthesis in Chinese hamster cells 2. Induction of DNA synthesis and cell division by Isoleucine and Glutamine in G1-arrested cells in suspension culture. J Cell Biol 47 (1970) 453-459
28. Tobey R.A., and Ley K.D. Regulation of initiation of DNA synthesis in Chinese hamster cells. I. Production of stable, reversible G1-arrested populations in suspension culture. J Cell Biol 46 (1970) 151-157
29. Koza R.A., and Herbst E.J. Deficiencies in DNA replication and cell-cycle progression in polyamine-depleted HeLa cells. Biochem J 281 Pt 1 (1992) 87-93
30. Martial A., Dardenme M., Engasser J.M., and Marc A. Influence of inoculum age on hybridoma culture kinetics. Cytotechnology 5 (1991) 165-171