Development of albumin-binding doxorubicin pro-drugs that are cleaved by prostate-specific antigen

Archiv der Pharmazie

Volumn 338, Issue 10, 2005, Pages 462-472

  Kratz, Felix ^a   Mansour, Ahmed ^a   Soltau, Jens ^a   Warnecke, Andre ^a   Fichtner, Iduna ^b   Unger, Clemens ^a   Drevs, Joachim ^a  

^a TUMOR BIOLOGY CENTER   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Doxorubicin; Human serum albumin; Macromolecular prodrug; Prostate specific antigen (PSA)

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; ARGININE; CYSTEINE; DIPEPTIDE; DOXORUBICIN; DOXORUBICIN DERIVATIVE; EPSILON MALEIMIDOCAPROIC ACID; EPSILON MALEIMIDOCAPROIC ACID ARGINYLARGINYLSERYLSERYLTYROSYLTYROSYLSERYLGLYCINE DOXORUBICIN DERIVATIVE; HEXANOIC ACID DERIVATIVE; HUMAN SERUM ALBUMIN; MALEIMIDE DERIVATIVE; MALEIMIDOTRIETHYLENEGLYCOL ACID; MALEIMIDOTRIETHYLENEGLYCOL SERYLSERYLTYROSYLTYROSYLSERYLGLYCINE DOXORUBICIN DERIVATIVE; PRODRUG; PROSTATE SPECIFIC ANTIGEN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DISSOCIATION; DRUG DESIGN; DRUG FORMULATION; DRUG PROTEIN BINDING; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MACROMOLECULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; TUMOR XENOGRAFT;

ALBUMINS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DOXORUBICIN; DRUG DESIGN; HUMANS; MALE; MALEIMIDES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PRODRUGS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROTEIN BINDING; SOLUBILITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 27644436770     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200500130     Document Type: Article

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