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Volumn 352, Issue 2, 2006, Pages 450-465

Genes of murine cytomegalovirus exist as a number of distinct genotypes

Author keywords

Gene polymorphism; Immune evasion; Multiple genotypes; Murine cytomegalovirus; Wild mice

Indexed keywords

ANIMAL CELL; ARTICLE; ASSAY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA POLYMORPHISM; EMBRYO; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC VARIABILITY; GENOTYPE; HETERODUPLEX ANALYSIS; HUMAN CYTOMEGALOVIRUS; IMMUNE RESPONSE; MEDICAL RESEARCH; MOUSE; MURINE CYTOMEGALOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS GENE; VIRUS ISOLATION; VIRUS STRAIN;

EID: 33747268006     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.04.031     Document Type: Article
Times cited : (36)

References (55)
  • 1
    • 0037123607 scopus 로고    scopus 로고
    • Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    • Arase H., Mocarski E.S., Campbell A.E., Hill A.B., and Lanier L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296 (2002) 1323-1326
    • (2002) Science , vol.296 , pp. 1323-1326
    • Arase, H.1    Mocarski, E.S.2    Campbell, A.E.3    Hill, A.B.4    Lanier, L.L.5
  • 2
    • 0037108926 scopus 로고    scopus 로고
    • Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease
    • Arav-Boger R., Willoughby R.E., Pass R.F., Zong J.C., Jang W.J., Alcendor D., and Hayward G.S. Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease. J. Infect. Dis. 186 (2002) 1057-1064
    • (2002) J. Infect. Dis. , vol.186 , pp. 1057-1064
    • Arav-Boger, R.1    Willoughby, R.E.2    Pass, R.F.3    Zong, J.C.4    Jang, W.J.5    Alcendor, D.6    Hayward, G.S.7
  • 3
    • 33644900710 scopus 로고    scopus 로고
    • Human cytomegalovirus-encoded a-chemokines exhibit high sequence variability in congenitally infected newborns
    • Arav-Boger R., Foster C.B., Zong J., and Pass R. Human cytomegalovirus-encoded a-chemokines exhibit high sequence variability in congenitally infected newborns. J. Infect. Dis. 193 (2006) 788-791
    • (2006) J. Infect. Dis. , vol.193 , pp. 788-791
    • Arav-Boger, R.1    Foster, C.B.2    Zong, J.3    Pass, R.4
  • 5
    • 19944407592 scopus 로고    scopus 로고
    • Predicting coding potential from genome sequence: application to betaherpesviruses infecting rats and mice
    • Brocchieri L., Kledal T.N., Karlin S., and Mocarski E.S. Predicting coding potential from genome sequence: application to betaherpesviruses infecting rats and mice. J. Virol. 79 (2005) 7570-7596
    • (2005) J. Virol. , vol.79 , pp. 7570-7596
    • Brocchieri, L.1    Kledal, T.N.2    Karlin, S.3    Mocarski, E.S.4
  • 6
    • 0037127265 scopus 로고    scopus 로고
    • The glycoprotein gp48 of murine cytomegalovirus - proteasome-dependent cytosolic dislocation and degradation
    • Bubeck A., Reusch U., Wagner M., Ruppert T., Muranyi W., Kloetzel P.M., and Koszinowski U.H. The glycoprotein gp48 of murine cytomegalovirus - proteasome-dependent cytosolic dislocation and degradation. J. Biol. Chem. 277 (2002) 2216-2224
    • (2002) J. Biol. Chem. , vol.277 , pp. 2216-2224
    • Bubeck, A.1    Reusch, U.2    Wagner, M.3    Ruppert, T.4    Muranyi, W.5    Kloetzel, P.M.6    Koszinowski, U.H.7
  • 7
    • 0347823003 scopus 로고    scopus 로고
    • MatGAT: an application that generates similarity/identity matrices using protein or DNA sequences
    • Campanella J.J., Bitincka L., and Smalley J. MatGAT: an application that generates similarity/identity matrices using protein or DNA sequences. BMC Bioinformatics 4 (2003) 29
    • (2003) BMC Bioinformatics , vol.4 , pp. 29
    • Campanella, J.J.1    Bitincka, L.2    Smalley, J.3
  • 8
    • 0029655755 scopus 로고    scopus 로고
    • Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains
    • Cha T., Tom E., Kemble G.W., Duke G.M., Mocarski E.S., and Spaete R.R. Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J. Virol. 70 (1996) 78-83
    • (1996) J. Virol. , vol.70 , pp. 78-83
    • Cha, T.1    Tom, E.2    Kemble, G.W.3    Duke, G.M.4    Mocarski, E.S.5    Spaete, R.R.6
  • 9
    • 0031984988 scopus 로고    scopus 로고
    • Characterization of a murine cytomegalovirus class I major histocompatibility complex (MHC) homolog: comparison to MHC molecules and to the human cytomegalovirus MHC homolog
    • Chapman T.L., and Bjorkman P.J. Characterization of a murine cytomegalovirus class I major histocompatibility complex (MHC) homolog: comparison to MHC molecules and to the human cytomegalovirus MHC homolog. J. Virol. 72 (1998) 460-466
    • (1998) J. Virol. , vol.72 , pp. 460-466
    • Chapman, T.L.1    Bjorkman, P.J.2
  • 11
    • 0141626870 scopus 로고    scopus 로고
    • CRANN: detecting adaptive evolution in protein-coding DNA sequences
    • Creevey C.J., and McInerney J.O. CRANN: detecting adaptive evolution in protein-coding DNA sequences. Bioinformatics 19 (2003) 1726
    • (2003) Bioinformatics , vol.19 , pp. 1726
    • Creevey, C.J.1    McInerney, J.O.2
  • 12
    • 0033517104 scopus 로고    scopus 로고
    • m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection
    • Cretney E., Degli-Esposti M.A., Densley E.H., Farrell H.E., Davis-Poynter N.J., and Smyth M.J. m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection. J. Exp. Med. 190 (1999) 435-444
    • (1999) J. Exp. Med. , vol.190 , pp. 435-444
    • Cretney, E.1    Degli-Esposti, M.A.2    Densley, E.H.3    Farrell, H.E.4    Davis-Poynter, N.J.5    Smyth, M.J.6
  • 15
    • 0034252303 scopus 로고    scopus 로고
    • Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages
    • Diefenbach A., Jamieson A.M., Liu S.D., Shastri N., and Raulet D.H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1 (2000) 119-126
    • (2000) Nat. Immunol. , vol.1 , pp. 119-126
    • Diefenbach, A.1    Jamieson, A.M.2    Liu, S.D.3    Shastri, N.4    Raulet, D.H.5
  • 18
    • 0030937295 scopus 로고    scopus 로고
    • Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo.[comment]
    • Farrell H.E., Vally H., Lynch D.M., Fleming P., Shellam G.R., Scalzo A.A., and Davis-Poynter N.J. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo.[comment]. Nature 386 6624 (1997) 510-514
    • (1997) Nature , vol.386 , Issue.6624 , pp. 510-514
    • Farrell, H.E.1    Vally, H.2    Lynch, D.M.3    Fleming, P.4    Shellam, G.R.5    Scalzo, A.A.6    Davis-Poynter, N.J.7
  • 20
    • 33646129465 scopus 로고    scopus 로고
    • Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice
    • Gorman S., Harvey N., Moro D., Lloyd M.L., Smith L.M., Lawson M., and Shellam G.R. Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice. J. Gen. Virol. 87 (2006) 1123-1132
    • (2006) J. Gen. Virol. , vol.87 , pp. 1123-1132
    • Gorman, S.1    Harvey, N.2    Moro, D.3    Lloyd, M.L.4    Smith, L.M.5    Lawson, M.6    Shellam, G.R.7
  • 21
    • 0344417055 scopus 로고    scopus 로고
    • Variation within the glycoprotein B gene of human cytomegalovirus is due to homologous recombination
    • Haberland M., Meyer-Konig U., and Hufert F.T. Variation within the glycoprotein B gene of human cytomegalovirus is due to homologous recombination. J. Gen. Virol. 80 (1999) 1495-1500
    • (1999) J. Gen. Virol. , vol.80 , pp. 1495-1500
    • Haberland, M.1    Meyer-Konig, U.2    Hufert, F.T.3
  • 22
    • 0024207944 scopus 로고
    • Analysis in vitro of two biologically distinct strains of murine cytomegalovirus
    • Hudson J.B., Walker D.G., and Altamirano M. Analysis in vitro of two biologically distinct strains of murine cytomegalovirus. Arch. Virol. 102 (1988) 289-295
    • (1988) Arch. Virol. , vol.102 , pp. 289-295
    • Hudson, J.B.1    Walker, D.G.2    Altamirano, M.3
  • 23
    • 0035476475 scopus 로고    scopus 로고
    • The multiple immune-evasion genes of murine cytomegalovirus are not redundant. M4 and m152 inhibit antigen presentation in a complementary and cooperative fashion
    • Kavanagh D.G., Gold M.C., Wagner M., Koszinowski U.H., and Hill A.B. The multiple immune-evasion genes of murine cytomegalovirus are not redundant. M4 and m152 inhibit antigen presentation in a complementary and cooperative fashion. J. Exp. Med. 194 (2001) 967-978
    • (2001) J. Exp. Med. , vol.194 , pp. 967-978
    • Kavanagh, D.G.1    Gold, M.C.2    Wagner, M.3    Koszinowski, U.H.4    Hill, A.B.5
  • 24
    • 0035478322 scopus 로고    scopus 로고
    • The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-Golgi compartment
    • Kavanagh D.G., Koszinowski U.H., and Hill A.B. The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-Golgi compartment. J. Immunol. 167 (2001) 3894-3902
    • (2001) J. Immunol. , vol.167 , pp. 3894-3902
    • Kavanagh, D.G.1    Koszinowski, U.H.2    Hill, A.B.3
  • 25
    • 0031050813 scopus 로고    scopus 로고
    • A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface
    • Kleijnen M.F., Huppa J.B., Lucin P., Mukherjee S., Farrell H., Campbell A.E., Koszinowski U.H., Hill A.B., and Ploegh H.L. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. EMBO J. 16 (1997) 685-694
    • (1997) EMBO J. , vol.16 , pp. 685-694
    • Kleijnen, M.F.1    Huppa, J.B.2    Lucin, P.3    Mukherjee, S.4    Farrell, H.5    Campbell, A.E.6    Koszinowski, U.H.7    Hill, A.B.8    Ploegh, H.L.9
  • 27
  • 28
    • 2442610845 scopus 로고    scopus 로고
    • Genetic variability and molecular epidemiology of respiratory syncytial virus subgroup a strains in Japan determined by heteroduplex mobility assay
    • Kuroiwa Y., Nagai K., Okita L., and Tsutsumi H. Genetic variability and molecular epidemiology of respiratory syncytial virus subgroup a strains in Japan determined by heteroduplex mobility assay. J. Clin. Microbiol. 42 (2004) 2048-2053
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 2048-2053
    • Kuroiwa, Y.1    Nagai, K.2    Okita, L.3    Tsutsumi, H.4
  • 29
    • 0037853132 scopus 로고    scopus 로고
    • NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    • Lodoen M., Ogasawara K., Hamerman J.A., Arase H., Houchins J.P., Mocarski E.S., and Lanier L.L. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 197 (2003) 1245-1253
    • (2003) J. Exp. Med. , vol.197 , pp. 1245-1253
    • Lodoen, M.1    Ogasawara, K.2    Hamerman, J.A.3    Arase, H.4    Houchins, J.P.5    Mocarski, E.S.6    Lanier, L.L.7
  • 30
    • 7244238978 scopus 로고    scopus 로고
    • The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions
    • Lodoen M.B., Abenes G., Umamoto S., Houchins J.P., Liu F., and Lanier L.L. The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J. Exp. Med. 200 (2004) 1075-1081
    • (2004) J. Exp. Med. , vol.200 , pp. 1075-1081
    • Lodoen, M.B.1    Abenes, G.2    Umamoto, S.3    Houchins, J.P.4    Liu, F.5    Lanier, L.L.6
  • 31
    • 8644241639 scopus 로고    scopus 로고
    • Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells
    • Loewendorf A., Kruger C., Borst E.M., Wagner M., Just U., and Messerle M. Identification of a mouse cytomegalovirus gene selectively targeting CD86 expression on antigen-presenting cells. J. Virol. 78 (2004) 13062-13071
    • (2004) J. Virol. , vol.78 , pp. 13062-13071
    • Loewendorf, A.1    Kruger, C.2    Borst, E.M.3    Wagner, M.4    Just, U.5    Messerle, M.6
  • 32
    • 0034608834 scopus 로고    scopus 로고
    • The RGD sequence in the cytomegalovirus DNA polymerase accessory protein can mediate cell adhesion
    • Loh L.C., Locke D., Melnychuk R., and Laferte S. The RGD sequence in the cytomegalovirus DNA polymerase accessory protein can mediate cell adhesion. Virology 272 (2000) 302-314
    • (2000) Virology , vol.272 , pp. 302-314
    • Loh, L.C.1    Locke, D.2    Melnychuk, R.3    Laferte, S.4
  • 33
    • 0029997167 scopus 로고    scopus 로고
    • Effect of natural sequence variation at the H-2Ld-restricted CD8+ T cell epitope of the murine cytomegalovirus ie1-encoded pp89 on T cell recognition
    • Lyons P.A., Allan J.E., Carrello C., Shellam G.R., and Scalzo A.A. Effect of natural sequence variation at the H-2Ld-restricted CD8+ T cell epitope of the murine cytomegalovirus ie1-encoded pp89 on T cell recognition. J. Gen. Virol. 77 (1996) 2615-2623
    • (1996) J. Gen. Virol. , vol.77 , pp. 2615-2623
    • Lyons, P.A.1    Allan, J.E.2    Carrello, C.3    Shellam, G.R.4    Scalzo, A.A.5
  • 35
    • 13444251528 scopus 로고    scopus 로고
    • RDP2: recombination detection and analysis from sequence alignments
    • Martin D.P., Williamson C., and Posada D. RDP2: recombination detection and analysis from sequence alignments. Bioinformatics 21 (2005) 260-262
    • (2005) Bioinformatics , vol.21 , pp. 260-262
    • Martin, D.P.1    Williamson, C.2    Posada, D.3
  • 39
    • 0001585190 scopus 로고
    • Cytomegalovirus and Other Herpesviruses
    • Foster H.L., Small J.D., and Fox J.G. (Eds)
    • Osborn J.E. Cytomegalovirus and Other Herpesviruses. In: Foster H.L., Small J.D., and Fox J.G. (Eds). The Mouse in Biomedical Research vol. II (1982) 267-292
    • (1982) The Mouse in Biomedical Research , vol.II , pp. 267-292
    • Osborn, J.E.1
  • 40
    • 0029981145 scopus 로고    scopus 로고
    • Analysis of the complete DNA sequence of murine cytomegalovirus
    • Rawlinson W.D., Farrell H.E., and Barrell B.G. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70 (1996) 8833-8849
    • (1996) J. Virol. , vol.70 , pp. 8833-8849
    • Rawlinson, W.D.1    Farrell, H.E.2    Barrell, B.G.3
  • 41
    • 0033558051 scopus 로고    scopus 로고
    • A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation
    • Reusch U., Muranyi W., Lucin P., Burgert H.G., Hengel H., and Koszinowski U.H. A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation. EMBO J. 18 (1999) 1081-1091
    • (1999) EMBO J. , vol.18 , pp. 1081-1091
    • Reusch, U.1    Muranyi, W.2    Lucin, P.3    Burgert, H.G.4    Hengel, H.5    Koszinowski, U.H.6
  • 42
    • 20444476488 scopus 로고    scopus 로고
    • Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes
    • Rossini G., Pignatelli S., Dal Monte P., Camozzi D., Lazzarotto T., Gabrielli L., Gatto M.R., and Landini M.P. Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes. Microbes Infect. 7 (2005) 890-896
    • (2005) Microbes Infect. , vol.7 , pp. 890-896
    • Rossini, G.1    Pignatelli, S.2    Dal Monte, P.3    Camozzi, D.4    Lazzarotto, T.5    Gabrielli, L.6    Gatto, M.R.7    Landini, M.P.8
  • 43
    • 0035988048 scopus 로고    scopus 로고
    • Fatal attraction: cytomegalovirus-encoded chemokine homologs
    • Saederup N., and Mocarski Jr. E.S. Fatal attraction: cytomegalovirus-encoded chemokine homologs. Curr. Top. Microbiol. Immunol. 269 (2002) 235-256
    • (2002) Curr. Top. Microbiol. Immunol. , vol.269 , pp. 235-256
    • Saederup, N.1    Mocarski Jr., E.S.2
  • 44
    • 0038168323 scopus 로고    scopus 로고
    • Field evaluation of the gag-based heteroduplex mobility assay for genetic subtyping of circulating recombinant forms of human immunodeficiency virus type 1 in Abidjan, Cote d'Ivoire
    • Sawadogo S., Adje-Toure C., Bile C.E., Ekpini R.E., Chorba T., and Nkengasong J.N. Field evaluation of the gag-based heteroduplex mobility assay for genetic subtyping of circulating recombinant forms of human immunodeficiency virus type 1 in Abidjan, Cote d'Ivoire. J. Clin. Microbiol. 41 (2003) 3056-3059
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 3056-3059
    • Sawadogo, S.1    Adje-Toure, C.2    Bile, C.E.3    Ekpini, R.E.4    Chorba, T.5    Nkengasong, J.N.6
  • 45
    • 84873776755 scopus 로고
    • Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease
    • Smith M.G. Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease. Proc. Soc. Exp. Biol. Med. 92 (1956) 424-430
    • (1956) Proc. Soc. Exp. Biol. Med. , vol.92 , pp. 424-430
    • Smith, M.G.1
  • 47
    • 9644302469 scopus 로고    scopus 로고
    • Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients
    • Stanton R., Westmoreland D., Fox J.D., Davison A.J., and Wilkinson G.W. Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. J. Med. Virol. 75 (2005) 42-46
    • (2005) J. Med. Virol. , vol.75 , pp. 42-46
    • Stanton, R.1    Westmoreland, D.2    Fox, J.D.3    Davison, A.J.4    Wilkinson, G.W.5
  • 48
    • 15444362108 scopus 로고    scopus 로고
    • Cytomegalovirus genotypes present in cerebrospinal fluid of HIV-infected patients
    • Steininger C., Schmied B., Sarcletti M., Geit M., and Puchhammer-Stockl E. Cytomegalovirus genotypes present in cerebrospinal fluid of HIV-infected patients. AIDS 19 (2005) 273-278
    • (2005) AIDS , vol.19 , pp. 273-278
    • Steininger, C.1    Schmied, B.2    Sarcletti, M.3    Geit, M.4    Puchhammer-Stockl, E.5
  • 49
    • 0033060142 scopus 로고    scopus 로고
    • The pathogenicity of cytomegalovirus
    • Sweet C. The pathogenicity of cytomegalovirus. FEMS Microbiol. Rev. 23 (1999) 457-482
    • (1999) FEMS Microbiol. Rev. , vol.23 , pp. 457-482
    • Sweet, C.1
  • 50
    • 13444266321 scopus 로고    scopus 로고
    • Genetic variability of the major histocompatibility Class I homologue encoded by human cytomegalovirus leads to differential binding to the inhibitory receptor ILT2
    • Vales-Gomez M., Shiroishi M., Maenaka K., and Reyburn H.T. Genetic variability of the major histocompatibility Class I homologue encoded by human cytomegalovirus leads to differential binding to the inhibitory receptor ILT2. J. Virol. 79 (2005) 2251-2260
    • (2005) J. Virol. , vol.79 , pp. 2251-2260
    • Vales-Gomez, M.1    Shiroishi, M.2    Maenaka, K.3    Reyburn, H.T.4
  • 52
    • 0036312026 scopus 로고    scopus 로고
    • Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities
    • Waldhoer M., Kledal T.N., Farrell H., and Schwartz T.W. Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J. Virol. 76 (2002) 8161-8168
    • (2002) J. Virol. , vol.76 , pp. 8161-8168
    • Waldhoer, M.1    Kledal, T.N.2    Farrell, H.3    Schwartz, T.W.4
  • 53
    • 0034608201 scopus 로고    scopus 로고
    • Mixed viral infection identified using heteroduplex mobility analysis (HMA
    • White P.A., Li Z., Zhai X., Marinos G., and Rawlinson W.D. Mixed viral infection identified using heteroduplex mobility analysis (HMA. Virology 271 (2000) 382-389
    • (2000) Virology , vol.271 , pp. 382-389
    • White, P.A.1    Li, Z.2    Zhai, X.3    Marinos, G.4    Rawlinson, W.D.5


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