Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass

Circulation

Volumn 114, Issue SUPPL. 1, 2006, Pages

  Ramlawi, Basel ^a   Feng, Jun ^a   Mieno, Shigetoshi ^a   Szabo, Csaba ^b,c   Zsengeller, Zsuzsanna ^d   Clements, Richard ^a   Sodha, Neel ^a   Boodhwani, Munir ^a   Bianchi, Cesario ^a   Sellke, Frank W ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c University of Medicine and Dentistry of New Jersey   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Blood cardioplegia; Extracorporeal circulation; Ischemia reperfusion; Myocardial protection; Signal transduction

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BCL 2; 3 NITROTYROSINE; 3-NITROTYROSINE; BAD PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; DRUG DERIVATIVE; MUSCLE PROTEIN; PDCD8 PROTEIN, HUMAN; TYROSINE;

ADULT; AGED; APOPTOSIS; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVITY; ENZYME ANALYSIS; EXTRACORPOREAL CIRCULATION; FEMALE; GENE EXPRESSION; HEART; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART RIGHT ATRIUM; HEART SURGERY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; MALE; MOLECULAR WEIGHT; NICK END LABELING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STAINING; SURGICAL PATIENT; BIOSYNTHESIS; BLOOD; CELL HYPOXIA; CHEMISTRY; COMPARATIVE STUDY; GENE EXPRESSION PROFILING; GENETICS; HEART ARREST; HEART ATRIUM APPENDAGE; METHODOLOGY; MIDDLE AGED; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

AGED; APOPTOSIS; APOPTOSIS INDUCING FACTOR; ATRIAL APPENDAGE; BCL-ASSOCIATED DEATH PROTEIN; BLOOD; CARDIOPULMONARY BYPASS; CASPASE 3; CASPASES; CELL HYPOXIA; FEMALE; GENE EXPRESSION PROFILING; HEART ARREST, INDUCED; HUMANS; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOCARDIAL REPERFUSION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; TYROSINE;

EID: 33747202779     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.000828     Document Type: Article

References (25)

1. Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease - a novel therapeutic target? FASEB J. 2002;16:135-146.
2. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 1994;94:1621-1628.
3. Anselmi A, Abbate A, Girola F, Nasso G, Biondi-Zoccai GG, Possati G, Gaudino M. Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence. Eur J Cardiothorac Surg. 2004;25:304-311.
4. Fischer UM, Klass O, Stock U, Easo J, Geissler HJ, Fischer JH, Bloch W, Mehlhorn U. Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes. Eur J Cardiothorac Surg. 2003;23:984-990.
5. Schmitt JP, Schroder J, Schunkert H, Birnbaum DE, Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg. 2002;73:1229-1235.
6. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94:481-490.
7. Haunstetter A, Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res. 1998;82:1111-1129.
8. Lipton SA, Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell. 2002;111:147-150.
9. Lorenzo HK, Susin SA, Penninger J, Kroemer G. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 1999;6:516-524.
10. Cooper WA, Duarte IG, Thourani VH, Nakamura M, Wang NP, Brown WM, 3rd, Gott JP, Vinten-Johansen J, Guyton RA. Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis. Ann Thorac Surg. 2000;69:696-702; discussion 703.
11. Cohen G, Borger MA, Weisel RD, Rao V. Intraoperative myocardial protection: current trends and future perspectives. Ann Thorac Surg. 1999;68:1995-2001.
12. Yeh CH, Wang YC, Wu YC, Chu JJ, Lin PJ. Continuous tepid blood cardioplegia can preserve coronary endothelium and ameliorate the occurrence of cardiomyocyte apoptosis. Chest. 2003;123:1647-1654.
13. Sellke FW, Shafique T, Johnson RG, Dai HB, Banitt PF, Schoen FJ, Weintraub RM. Blood and albumin cardioplegia preserve endothelium-dependent microvascular responses. Ann Thorac Surg. 1993;55:977-985.
14. Aebert H, Kirchner S, Keyser A, Birnbaum DE, Holler E, Andreesen R, Eissner G. Endothelial apoptosis is induced by serum of patients after cardiopulmonary bypass. Eur J Cardiothorac Surg. 2000;18:589-593.
15. Vohra HA, Fowler AG, Galinanes M. Preconditioning with cardioplegia is more effective in reducing apoptosis than is preconditioning with ischemia in the human myocardium. Ann N Y Acad Sci. 2003;1010:721-727.
16. Aebert H, Cornelius T, Birnbaum DE, Siegel AV, Riegger GA, Schunkert H. Induction of early immediate genes and programmed cell death following cardioplegic arrest in human hearts. Eur J Cardiothorac Surg. 1997;12:261-267.
17. Fischer UM, Tossios P, Huebner A, Geissler HJ, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2004;128:103-108.
18. Ruel M, Bianchi C, Khan TA, Xu S, Liddicoat JR, Voisine P, Araujo E, Lyon H, Kohane IS, Libermann TA, Sellke FW. Gene expression profile after cardiopulmonary bypass and cardioplegic arrest. J Thorac Cardiovasc Surg. 2003;126:1521-1530.
19. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999;397:441-446.
20. Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC. Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease. Blood. 2004;104:3789-3796.
21. Kuwahara K, Saito Y, Kishimoto I, Miyamoto Y, Harada M, Ogawa E, Hamanaka I, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Nakao K. Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes. J Mol Cell Cardiol. 2000;32:1385-1394.
22. Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, Ullmann C, Lorenz-Meyer S, Schaper J. Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol. 2000;32:197-208.
23. Uchiyama T, Engelman RM, Maulik N, Das DK. Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation. 2004;109:3042-3049.
24. Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, Ronson RS, Guyton RA, Vinten-Johansen J. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res. 2000;45:651-660.
25. Araujo EG, Bianchi C, Sato K, Faro R, Li XA, Sellke FW. Inactivation of the MEK/ERK pathway in the myocardium during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2001;121:773-781.