Preconditioning with Cardioplegia Is More Effective in Reducing Apoptosis Than Is Preconditioning with Ischemia in the Human Myocardium

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 721-727

  Vohra, Hunaid A ^a   Fowler, Alan G ^a   Galiñanes, Manuel ^a  

^a GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Cardioplegia; Ischemia; Myocardium; Preconditioning

Indexed keywords

CREATINE KINASE;

APOPTOSIS; CARDIOPLEGIA; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME RELEASE; HEART MUSCLE; HEART MUSCLE NECROSIS; HEART PROTECTION; HUMAN; HUMAN TISSUE; INCUBATION TIME; INTERMETHOD COMPARISON; ISCHEMIA; TISSUE INJURY; TISSUE NECROSIS;

EID: 1342284237     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.130     Document Type: Conference Paper

References (18)

1. GOTTLIEB, R.A., K.O. BURLESON, R.A. KLONER, et al. 1994. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94: 1621-1628.
2. ZHANG, J.G., S. GHOSH, C. OCKLEFORD & M. GALINANES. 2000. Characterisation of an in-vitro model for the study of the short and prolonged effects of myocardial ischemia and reperfusion in man. Clin. Sci. 99: 339-350.
3. BORUTAITE, V., A. BUDRIUNAITE, R. MORKUNIENE & G.C. BROWN. 2001. Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia. Biochim. Biophys. Acta 1537: 101-109.
4. KAJSTURA, J., W. CHENG, K. REISS, et al. 1996. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 74: 86-107.
5. OKAMURA, T., T. MIURA, G. TAKEMURA, et al. 2000. Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc. Res. 45: 642-650.
6. ZWEIER, J.L., J.T. FLAHERTY & M.L. WEISFELDT. 1987. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA 84: 1404-1407.
7. BLASIG, I.E., S. SHUTER, P. GARLICK & T. SLATER. 1994. Relative time-profiles for free radical trapping, coronary flow, enzyme leakage, arrhythmias, and function during myocardial reperfusion. Free Radical Biol. Med. 16: 35-41.
8. ZHAO, Z.Q. & J. VINTEN-JOHANSEN. 2002. Myocardial apoptosis and ischemic preconditioning. Cardiovasc. Res. 55: 438-455.
9. JOYEUX, M., D. GODIN-RIBUOT & C. RIBUOT. 1998. Resistance to myocardial infarction induced by heat stress and the effect of ATP-sensitive potassium channel blockade in the rat isolated heart. Br. J. Pharmacol. 123: 1085-1088.
10. AKAO, M., A. OHLER & M.E. O'ROURKE. 2001. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ. Res. 88: 1267-1275.
11. LOUBANI, M. & M. GALIÑANES. 2002. Pharmacological and ischemic preconditioning of the human myocardium: mito-KATP channels are upstream and p38MAPK is downstream of PKC. BioMed. Central Physiol. 18: 10.
12. LUI, H., B. MCPHERSON & Z. YAO. 2001. Preconditioning attenuates apoptosis and necrosis: role of protein kinaseCε and -δ isoforms. Am. J. Physiol. Heart Circ. Physiol. 281: H404-H410.
13. WANG, Y. & M. ASHRAF. 1999. Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca21 overload injury in rat myocardium. Circ. Res. 84: 1156-1165.
14. SCAFFIDI, C., I. SCHMITZ, J. ZHA, et al. 1999. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem. 274: 22532-22538.
15. NING, X.H., S.H. CHEN, C.S. XU, et al. 2002. Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J. Appl. Physiol. 92: 2200-2207.
16. + homeostasis in apoptosis. Presented at Apoptosis 2003: From Signalling Pathways to Therapeutic Tools, Luxembourg.
17. JU, H. 1992. Protective effects of high potassium administered after ischemic arrest against reperfusion injury in isolated rat hearts. Zhonghua Xin Xue Guan Bing Za Zhi 20: 182-184.
18. KO, T., H. OTANI, H. IMAMURA, et al. 1995. Role of sodium pump activity in warm induction of cardioplegia combined with reperfusion of oxygenated cardioplegic solution. J. Thorac. Cardiovasc. Surg. 110: 103-110.