Effect of ramipril on ischemia-reperfusion induced apoptosis of cardiomyocyte and expression of apoptosis-related genes

Chinese Pharmacological Bulletin

Volumn 22, Issue 5, 2006, Pages 625-628

  Song, Jun Qiu ^a   Liu, Yan Xia ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2 Bax; Myocardiam ischemia reperfusion; Ramipril

Indexed keywords

DNA; PROTEIN BAX; PROTEIN BCL 2; RAMIPRIL; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HEART INFARCTION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; NICK END LABELING; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 33747202500     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ji X, Tan B K, Zhu Y C, et al. Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats[J]. Life Sci, 2003, 73(11):1413-26.
2. Liu J J, Peng L, Bradley C J, et al. Increased apoptosis in the heart of genetic hypertension, associated with fibroblasts[J]. Cardiovasc Res, 2000, 45(3):729-35.
3. Zhang H F, Fan Q, Qian X X, et al. Role of insulin in the antiapoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis, 2004, 9(6):777-83.
4. Wang N, Minatoguchi S, Chen X, et al. Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart. Br J Pharmacol, 2004, 142(6):983-90.
5. Murriel C L, Churchill E, Inagaki K, et al. Protein kinase C-delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem, 2004, 279(46):47985-91.
6. Kajstura J, Reiss K. Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab Invest, 1996, 74(1):86-107.
7. Peart J N, Gross E R, Gross G J. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. J Cardiovasc Pharmacol, 2004, 43(3):410-5.
8. Stadelmann C, Lassmann H. Detection of apoptosis in tissue sections[J]. Cell Tissue Res, 2000, 301(1):19-31.
9. Dong JW, Zhu H F, Zhu W Z, et al. Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating bcl-2/Bax expression[J]. Cell Res, 2003, 13(5): 385-91.