Diagnostic specificity and predictors of neurological soft signs in schizophrenia, bipolar disorder and other psychoses over the first 4 years of illness

Schizophrenia Research

Volumn 86, Issue 1-3, 2006, Pages 110-117

  Whitty, Peter ^a   Clarke, Mary ^a   McTigue, Orfhlaith ^a   Browne, Stephen ^a   Gervin, Maurice ^a   Kamali, Moyaad ^a   Lane, Abbie ^a   Kinsella, Anthony ^c   Waddington, John ^d   Larkin, Conall ^a,b   O'Callaghan, Eadbhard ^a,b,e  

^a St John of God Hospitaller Services Ireland   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^e DETECT   (Ireland)

Author keywords

First episode psychosis; Neurological soft signs

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; BRAIN FUNCTION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FOLLOW UP; HANDEDNESS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; TIME SERIES ANALYSIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; BIPOLAR DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; INTERVIEWS; INTERVIEWS AS TOPIC; LONGITUDINAL STUDIES; MALE; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SENSITIVITY AND SPECIFICITY;

EID: 33747201093     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2006.04.012     Document Type: Article

References (42)

1. Andreasen N.C., Swayze V., Flaum M., Alliger R., and Cohen G. Ventricular abnormalities in affective disorder: clinical and demographic correlates. Am. J. Psychiatry 147 (1990) 893-900
2. APA. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 4th edn (1994), American Psychiatric Association, Washington, DC
3. Boks M.P., Russo S., Knegtering R., and van den Bosch R.J. The specificity of neurological signs in schizophrenia: a review. Schizophr. Res. 43 (2000) 109-116
4. Boks M.P., Liddle P.F., Knegtering R., and van den Bosch R.J. Neurological soft signs discriminating mood disorders from first episode schizophrenia. Acta Psychiatr. Scand. 110 (2004) 29-35
5. Breier A., Schreider J.L., Dyer J., and Pickar D. National Institute of Mental Health longitudinal study of chronic schizophrenia. Arch. Gen. Psychiatry 48 (1991) 239-246
6. Browne S., Clarke M., Gervin M., Lane A., Waddington J.L., Larkin C., and O'Callaghan E. Determinants of neurological dysfunction in first episode schizophrenia. Psychol. Med. 30 (2000) 1433-1441
7. Browne S., Clarke M., Gervin M., Waddington J.L., Larkin C., and O'Callaghan E. Determinants of quality of life at first presentation with schizophrenia. Br. J. Psychiatry 176 (2000) 173-176
8. Caligiuri M.P., and Lohr J.B. A disturbance in the control of muscle force in neuroleptic-naïve schizophrenic patients. Biol. Psychiatry 35 (1994) 104-111
9. Chen E.Y., Kwok C.L., Au J.W., Chen R.Y., and Lau B.S. Progressive deterioration of soft neurological signs in chronic schizophrenic patients. Acta Psychiatr. Scand. 102 (2000) 342-349
10. Chen E.Y., Hui C.L., Chan R.C., Dunn E.L., Miao M.Y., Yeung W., Wong C., Chan W., and Tang W. A 3-year prospective study of neurological soft signs in first-episode schizophrenia. Schizophr. Res. 75 (2005) 45-54
11. Dazzan P., and Murray R.M. Neurological soft signs in first-episode psychosis: a systematic review. Br. J. Psychiatr., (Suppl.) 181 (2002) 50-57
12. Emsley R., Turner H.J., Oosthuizen P.P., and Carr J. Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical outcome correlates. Schizophr. Res. 75 (2005) 35-44
13. Fenton W.S., and McGlashan T.H. Sustained remission in drug-free schizophrenic patients. Am. J. Psychiatry 144 (1987) 1306-1309
14. Flyct L., Sydow O., Bjerkenstedt L., Edman G., Rydin E., and Wiesel F.A. Neurological signs and psychomotor performance in patients with schizophrenia, their relatives and healthy controls. Psychiatry Res. 153 (1999) 526-532
15. Gupta S., Andreasan N.C., Arndt S., Flaum M., Schultz S.K., Hubbard W., and Smith M. Neurological soft signs in neuroleptic-naïve and schizophrenic patients and in normal comparison subjects. Am. J. Psychiatry 152 (1995) 191-196
16. Harrigan S.M., McGorry P.D., and Krstev H. Does treatment delay in first-episode psychosis really matter?. Psychol. Med. 33 (2003) 97-110
17. Heinrichs D.W., and Buchanan R.W. Significance and meaning of neurological signs in schizophrenia. Am. J. Psychiatry 145 (1988) 11-18
18. Johnstone E.C., Macmillan J.F., Frith C.D., Benn D.K., and Crow T.J. Further investigation of the predictors of outcome following first schizophrenic episodes. Br. J. Psychiatry 157 (1990) 182-189
19. Kay S.R., Fiszbein A., and Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 13 (1987) 261-276
20. Kennard M.A. Value of equivocal signs in neurological diagnosis. Neurology 10 (1960) 753-764
21. Keshavan M.S., Sanders R.D., Sweeney J.A., Diwadkar V.A., Goldstein G., Pettegrew J.W., and Schooler N.R. Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. Am. J. Psychiatry 160 (2003) 1298-1304
22. Kohler C., Swanson C.L., Gur R.C., Mozley L.H., and Gur R.E. Depression in schizophrenia: II. MRI and PET findings. Biol. Psychiatry 43 (1998) 173-180
23. Kolakowska T., Williams A.O., Jambor K., and Ardern M. Schizophrenia with good and poor outcome. III. Neurological 'soft signs', cognitive impairments and their clinical significance. Br. J. Psychiatry 146 (1985) 348-357
24. Løberg E.-M., Jørgensen H.A., Green M.F., Rund B.R., Lund A., Diseth Å., Øie M., and Hugdahl K. Positive symptoms and duration of illness predict functional laterality and attention modulation in schizophrenia. Acta Psychiatr. (2005) 1-10
25. Loebel A.D., Lieberman J.A., Alvir J.M.J., Mayerhoff D.I., Geisler S.H., and Szymanski S.R. Duration of psychosis and outcome in first-episode schizophrenia. Am. J. Psychiatry 149 (1992) 1183-1188
26. Madsen A.L., Vorstrup S., Rubin P., Larsen J.K., and Hemmingsen R. Neurological abnormalities in schizophrenic patients: a prospective follow-up study 5 years after first admission. Acta Psychiatr. Scand. 100 (1999) 119-125
27. Manschreck T.C., Maher B.A., Rucklos M.E., Vereen Jr. D.R., and Ader D.N. Disturbed voluntary motor activity in schizophrenic disorder. Psychol. Med. 12 (1982) 73-84
28. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 9 (1971) 97-113
29. Rossi A., De Cataldo S., Di Michele V., Manna V., Ceccoli S., Stratta P., and Casacchia M. Neurological soft signs in schizophrenia. Br. J. Psychiatry 157 (1990) 735-739
30. Sanders R.D., Keshavan M.S., and Schooler N.R. Neurological examination abnormalities in neuroleptic-naïve patients with first-break schizophrenia: preliminary results. Am. J. Psychiatry 151 (1994) 1231-1233
31. Satz P., and Green M.F. Atypical handedness in schizophrenia: Some methodological and theoretical issues. Schizophr. Bull. 25 (1999) 63-78
32. Schröder J., Niethammer R., Geider F.J., Reitz C., Binkert M., Jauss M., and Sauer H. Schizophr. Res. 6 (1992) 25-30
33. Smith R.C., Hussain M.I., Chowdhury S.A., and Stearns A. Stability of neurological soft signs in chronically hospitalised schizophrenic patients. J. Neuropsychiatry Clin. Neurosci. 11 (1999) 91-96
34. SPSS Inc., 2001. Release 11.0.1. Statistical Package for the Social Sciences for Windows, Chicago, IL, USA.
35. Strauss J.S., and Carpenter W.T. The prediction of outcome in schizophrenia: II. Relationship between predictors and outcome variables. Arch. Gen. Psychiatry 31 (1974) 37-42
36. Taylor M.A. Are schizophrenia and affective disorder related? A selective literature review. Am. J. Psychiatry 149 (1992) 22-32
37. Torrey E.F. Neurological abnormalities in schizophrenic patients. Biol. Psychiatry 15 (1980) 381-389
38. Torrey E.F. Epidemiological comparison of schizophrenia and bipolar disorder. Schizophr. Res. 29 (1999) 101-106
39. Tucker G.J., and Silberfarb P.M. Neurologic dysfunction schizophrenia: significance for diagnostic practice. In: Akiskal H., and Webb W. (Eds). Psychiatric Diagnosis. Exploration of Biological Predictors (1978), Spektrum, New York 453-462
40. Whitty P., Clarke M., Browne S., McTigue O., Kamali M., Feeney L., Lane A., Kinsella A., Waddington J.L., Larkin C., and O'Callaghan E. Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena. Psychol. Med. 33 (2003) 1479-1484
41. Wong A.H., Voruganti L., Heslegrave R.J., and Awad A.G. Neurocognitive deficits and neurological signs in schizophrenia. Schizophr. Res. 23 (1997) 139-146
42. Wyatt R.J., Green M.F., and Tuma A.H. Long-term morbidity associated with delayed treatment of first-admission schizophrenic patients: a reanalysis of the Camarillo State Hospital data. Psychol. Med. 27 (1997) 261-268