y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages

Amino Acids

Volumn 31, Issue 2, 2006, Pages 101-109

  Baydoun, A R ^a   Bertran, J ^c   Thakur, S ^a   Dawson, J ^b   Palacin M ^c   Knowles, R G ^b  

^a UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Amino acid transport; GW274150; Inducible nitric oxide synthase; J774 macrophages; Nitric oxide; System y+; y+LAT 1

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; AMINO ACID DERIVATIVE; AMINO ACID TRANSPORTER; ARGININE; GLUTAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUCINE; LYSINE; METHIONINE; N ETHYLMALEIMIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN LAT 1; PROTEIN LAT 2; S [2 (1 IMINOETHYLAMINO)ETHYL]HOMOCYSTEINE; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG TRANSPORT; DRUG UPTAKE; MACROPHAGE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID TRANSPORT SYSTEM Y+L; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CELL LINE; ENZYME INHIBITORS; ETHYLMALEIMIDE; HYDROGEN-ION CONCENTRATION; MACROPHAGES; MICE; NITRIC OXIDE SYNTHASE TYPE II; SODIUM; SULFIDES;

MURINAE;

EID: 33747145643     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-005-0311-9     Document Type: Conference Paper

References (53)

1. WK Alderton CE Cooper RG Knowles 2001 Nitric oxide synthases: structure, function and inhibition Biochem J 357 593 615
2. +L of human erythrocytes: specificity and cation dependence of the translocation step J Membr Biol 141 183 192
3. BR Babu OW Griffith 1998 Design of isoform-selective inhibitors of nitric oxide synthase Curr Opin Chem Biol 2 491 500
4. + in activated macrophages Biochem Biophys Res Commun 200 726 731
5. AR Baydoun RG Bogle JD Pearson GE Mann 1994 Discrimination between citrulline and arginine transport in activated murine macrophages: Inefficient synthesis of NO from recycling of citrulline to arginine Br J Pharmacol 112 487 492
6. J Bertran A Werner ML Moore G Stange D Markovich J Biber X Testar A Zorzano M Palacin H Murer 1992 Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids Proc Natl Acad Sci USA 89 5601 5605
7. RG Bogle AR Baydoun JD Pearson S Moncada GE Mann 1992 L-arginine transport is increased in macrophages generating nitric oxide Biochem J 284 15 18
8. +LAT2 mediates arginine efflux in exchange with glutamine Biochem J 349 787 795
9. HN Christensen 1990 Role of amino acid transport and countertransport in nutrition and metabolism Physiol Rev 70 43 77
10. HN Christensen ME Handlogten I Lam HS Tager R Zand 1969 A bicyclic amino acid to improve discriminations among transport systems J Biol Chem 244 1510 1520
11. +-requiring transport system for alanine, serine, cysteine, and similar amino acids J Biol Chem 242 5237 5246
12. HN Christensen DL Oxender M Liang KA Vatz 1965 The use of N-methylation to direct route of mediated transport of amino acids J Biol Chem 240 3609 3616
13. +L in cultured human fibroblasts: normal phenotype of cells from LPI subjects Am J Physiol 279 C1829 C1837
14. R Deves S Angelo P Chavez 1993 N-ethylmaleimide discriminates between two lysine transport systems in human erythrocytes J Physiol 468 753 766
15. +L: the broad scope and cation modulated amino acid transporter Exp Physiol 83 211 220
16. R Deves CA Boyd 1998 Transporters for cationic amino acids in animal cells: discovery, structure, and function Physiol Rev 78 487 545
17. +L in human erythrocytes that recognizes lysine and leucine with high affinity J Physiol 454 491 501
18. +L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen Biochemistry 34 8744 8751
19. L Goldstein 1975 Glutamine transport by mitochondria isolated from normal and acidotic rats Am J Physiol 229 1027 1033
20. SS Gross MS Wolin 1995 Nitric oxide: Pathophysiological mechanisms Annu Rev Physiol 57 737 769
21. AJ Hobbs A Higgs S Moncada 1999 Inhibition of nitric oxide synthase as a potential therapeutic target Annu Rev Pharmacol Toxicol 39 191 220
22. G Julou-Schaeffer GA Gray I Fleming C Schott JR Parratt JC Stoclet 1990 Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway Am J Physiol 259 H1038 H1043
23. MS Kilberg ME Handlogten HN Christensen 1980 Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs J Biol Chem 255 4011 4019
24. JW Kim EI Closs LM Albritton JM Cunningham 1991 Transport of cationic amino acids by the mouse ecotropic retrovirus receptor Nature 352 725 728
25. RG Knowles S Moncada 1994 Nitric oxide synthases in mammals Biochem J 298 249 258
26. JA Lorente L Landín R De Pablo E Renes D Liste 1993 L-arginine pathway in the sepsis syndrome Crit Care Med 21 1287 1295
27. MD Messeri Dreißig R Hammermann J Mössner M Göthert K Racké 2000 In rat alveolar macrophages lipopolysaccharides exert divergent effects on the transport of the cationic amino acids L-arginine and L-ornithine Naunyn Schmiedebergs Arch Pharmacol 361 621 628
28. N [tmp] McCartney-Francis JB Allen DE Mizel JE Albina Q-W Xie CF Nathan SM Wahl 1993 Suppression of arthritis by an inhibitor of nitric oxide synthase J Exp Med 178 749 754
29. JD [tmp] McGivan M Pastor-Anglada 1994 Regulatory and molecular aspects of mammalian amino acid transport Biochem J 299 321 334
30. S Moncada RMJ Palmer EA Higgs 1991 Nitric oxide: Physiology, pathophysiology, and pharmacology Pharmacol Rev 43 109 142
31. JB Ochoa AO Udekwu TR Billiar RD Curran FB Cerra RL Simmons AB Peitzman 1991 Nitrogen oxide levels in patients after trauma and during sepsis Ann Surg 214 621 626
32. DL Oxender HN Christensen 1963 Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell J Biol Chem 238 3686 3699
33. M Palacin R Estevez J Bertran A Zorzano 1998 Molecular biology of mammalian plasma membrane amino acid transporters Physiol Rev 78 969 1054
34. JM Patel AJ Abeles ER Block 1996 Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells Free Radic Biol Med 20 629 637
35. GJ Peter A Davies PW Watt J Birrell PM Taylor 1999 Interactions between the thiol-group reagent N-ethylmaleimide and neutral and basic amino acid transporter-related amino acid transport Biochem J 343 169 176
36. +L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family EMBO J 18 49 57
37. K Racké C Hey J Mössner R Hammermann C Stichnote I Wessler 1998 Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages J Physiol 511 813 825
38. DD Rees RM Palmer S Moncada 1989 Role of endothelium-derived nitric oxide in the regulation of blood pressure Proc Natl Acad Sci USA 86 3375 3378
39. +L in human monocytes FEBS Lett 571 177 181
40. +L activity and transepithelial delivery of NOS inhibitors FASEB J 19 810 812
41. KM Sanders SM Ward 1992 Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission Am J Physiol 263 G379 G392
42. PK Smith RI Krohn GT Hermanson AK Mallia FH Gartner MD Provenzano EK Fujimoto NM Goeke BJ Olson DC Klenk 1985 Measurement of protein using bicinchoninic acid Anal Biochem 150 76 85
43. R Torczynski AP Bollon M Fuke 1983 The complete nucleotide sequence of the rat 18S ribosomal RNA gene and comparison with the respective yeast and frog genes Nucleic Acids Res 11 4879 4890
44. +L. A candidate gene for lysinuric protein intolerance J Biol Chem 273 32437 32445
45. I Tsuneyoshi Y Kanmura N Yoshimura 1996 Nitric oxide as a mediator of reduced arterial responsiveness in septic patients Crit Care Med 24 1083 1086
46. P Vallance J Collier S Moncada 1989 Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man Lancet 2 997 1000
47. +-independent transport of basic and zwitterionic amino acids in mouse blastocysts by a shared system and by processes which distinguish between these substrates J Biol Chem 263 3150 3163
48. +-dependent transport of basic, zwitterionic, and bicyclic amino acids by a broad-scope system in mouse blastocysts J Biol Chem 260 12118 12123
49. H Wang MP Kavanaugh RA North D Kabat 1991 Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter Nature 352 729 731
50. RG Wells MA Hediger 1992 Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases Proc Natl Acad Sci USA 89 5596 5600
51. MF White 1985 The transport of cationic amino acids across the plasma membrane of memmalian cells Biochim Biophys Acta 822 355 374
52. T Yamada RB Sartor S Marshall RD Specian MB Grisham 1993 Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats Gastroenterology 104 759 771
53. RJ Young RM Beams K Carter HA Clark DM Coe CL Chambers PI Davies J Dawson MJ Drysdale KW Franzman C French ST Hodgson HF Hodson S Kleanthous P Rider D Sanders DA Sawyer KJ Scott BG Shearer R Stocker S Smith MC Tackley RG Knowles 2000 Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine Bioorg Med Chem Lett 10 597 600