The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission

Neuropharmacology

Volumn 51, Issue 3, 2006, Pages 681-691

  Inaba, Yuji ^a   Biagini, Giuseppe ^b   Avoli, Massimo ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

4 aminopyridine; Epileptiform activity; GABA receptor antagonists; Ih; Neocortex; ZD7288

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; CESIUM;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; ELECTRIC CURRENT; EPILEPTIC DISCHARGE; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITION KINETICS; MALE; MEMBRANE CURRENT; NEOCORTEX; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; RECORDING; SYNAPTIC TRANSMISSION;

4-AMINOPYRIDINE; ANIMALS; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPILEPSY; MALE; NEOCORTEX; NEURAL INHIBITION; POTASSIUM CHANNEL BLOCKERS; PYRIMIDINES; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 33747055293     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.05.017     Document Type: Article

References (30)

1. Agmon A., and Wells J.E. The role of the hyperpolarization-activated cationic current I(h) in the timing of interictal bursts in the neonatal hippocampus. Journal of Neuroscience 23 (2003) 3658-3668
2. h channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. Journal of Neurophysiology 85 (2001) 855-868
3. Castro-Alamancos M.A., and Connors B.W. Cellular mechanisms of the augmenting response: short-term plasticity in a thalamocortical pathway. Journal of Neuroscience 16 (1996) 7742-7756
4. Chen C. ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses. European Journal of Neuroscience 19 (2004) 643-649
5. Chen K., Aradi I., Thon N., Eghbal-Ahmadi M., Baram T.Z., and Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature Medicine 7 (2001) 331-337
6. h channels in synaptic transmission and mossy fiber LTP. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 9938-9543
7. Connors B.W., Gutnick M.J., and Prince D.A. Electrophysiological properties of neocortical neurons in vitro. Journal of Neurophysiology 48 (1982) 1302-1320
8. Crunelli V., and Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Reviews Neuroscience 3 (2002) 371-382
9. D'Ambrosio R., Wenzel J., Schwartzkroin P.A., McKhann II G.M., and Janigro D. Functional specialization and topographic segregation of hippocampal astrocytes. Journal of Neuroscience 18 (1998) 4425-4438
10. Dickson C.T., Magistretti J., Shalinsky M.H., Fransen E., Hasselmo M.E., and Alonso A. Properties and role of I(h) in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons. Journal of Neurophysiology 83 (2000) 2562-2579
11. Di Pasquale E., Keegan K.D., and Noebels J.L. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. Journal of Neurophysiology 77 (1997) 621-631
12. h) blocker ZD7288 in hippocampal CA1 neurons. Pflügers Archiv European Journal of Physiology 435 (1997) 99-106
13. Guerrini R., Andermann E., Avoli M., and Dobyns W.B. Cortical dysplasias, genetics and epileptogenesis. In: Delgado-Escueta A.V., Wilson W., Olsen R.W., and Porter R.J. (Eds). Jasper's Basic Mechanisms of the Epilepsies, Advances in Neurology 79 (1999), Lippincott-Raven Publishers, New York 95-121
14. Harris N.C., and Constanti A. Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. Journal of Neurophysiology 74 (1995) 2366-2378
15. + uptake in glia prevents long-term depression maintenance and causes epileptiform activity. Journal of Neuroscience 17 (1997) 2813-2824
16. Ludwig A., Budde T., Stieber J., Moosmang S., Wahl C., Holthoff K., Langebartels A., Wotjak C., Munsch T., Zong X., Feil S., Feil R., Lancel M., Chien K.R., Konnerth A., Pape H.C., Biel M., and Hofmann F. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO (European Molecular Biology Organization) Journal 22 (2003) 216-224
17. Magee J.C. Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. Journal of Neuroscience 18 (1998) 7613-7624
18. McCormick D.A., and Contreras D. On the cellular and network bases of epileptic seizures. Annual Review of Physiology 63 (2001) 815-846
19. McCormick D.A., Connors B.W., Lighthall J.W., and Prince D.A. Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. Journal of Neurophysiology 54 (1985) 782-806
20. h channels. Science 295 (2002) 143-147
21. Pape H.C. Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual Review of Physiology 58 (1996) 299-327
22. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. fourth ed. (1998), Academic Press, San Diego
23. Poolos N.P., Migliore M., and Johnston D. Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature Neuroscience 5 (2002) 767-774
24. Shah M.M., Anderson A.E., Leung V., Lin X., and Johnston D. Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 44 (2004) 495-508
25. Spain W.J., Schwindt P.C., and Crill W.E. Anomalous rectification in neurons from cat sensorimotor cortex in vitro. Journal of Neurophysiology 57 (1987) 1555-1576
26. Steriade M. Interneuronal epileptic discharges related to spike-and-wave cortical seizures in behaving monkeys. Electroencephalography and Clinical Neurophysiology 37 (1974) 247-263
27. h is associated with enhanced excitability and absence epilepsy. European Journal of Neuroscience 19 (2004) 3048-3058
28. Timofeev I., and Steriade M. Neocortical seizures: initiation, development and cessation. Neuroscience 123 (2004) 299-336
29. Timofeev I., Bazhenov M., Sejnowski T., and Steriade M. Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 9533-9537
30. Williams S.R., Turner J.P., Hughes S.W., and Crunelli V. On the nature of anomalous rectification in thalamocortical neurones of the cat ventrobasal thalamus in vitro. Journal of Physiology (London) 505 (1997) 727-747