A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure-activity relationships (2)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3697-3711

  Nomura, Takashi ^a   Iwaki, Tsutomu ^a   Narukawa, Yukitoshi ^a   Uotani, Koichi ^a   Hori, Toshihiko ^a   Miwa, Hideaki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Antibacterial activity; Antibiotic; C 9 iminoether; Erythromycin resistant; Ketolide; Macrolide; N Aryl alkyl acetamide; Pharmacokinetic property

Indexed keywords

ERYTHROMYCIN; KETOLIDE; N (3 QUINOXALIN 6 YLPROPYL)PROPIONAMIDE; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; ETHER DERIVATIVE; IMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL PNEUMONIA; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; HAEMOPHILUS INFLUENZAE; MOUSE; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; IN VITRO STUDY; MICROBIOLOGICAL EXAMINATION; STEREOISOMERISM; SYNTHESIS;

HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE;

ACETAMIDES; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; ETHERS; HAEMOPHILUS INFLUENZAE; IMINES; KETOLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747051802     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.036     Document Type: Article

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