Mesangial cell-predominant functional gene, megsin

Clinical and Experimental Nephrology

Volumn 7, Issue 2, 2003, Pages 87-92

  Inagi, Reiko ^a   Nangaku, Masaomi ^b   Miyata, Toshio ^a   Kurokawa, Kiyoshi ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Diabetic; Ig A nephropathy; Immune complex; Mesangial expansion; Nephropathy; Plasmin; Serpin

Indexed keywords

MEGSIN; SERINE PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; DIABETIC NEPHROPATHY; GENE EXPRESSION REGULATION; GENE ISOLATION; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; MOLECULAR CLONING; NONHUMAN; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

ALPHA 1-ANTITRYPSIN; ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; HUMANS; KIDNEY DISEASES; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SERPINS;

EID: 0041810422     PISSN: 13421751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10157-003-0228-0     Document Type: Review

References (31)

1. Shimizu F, Kawachi H, Orikasa M. Role of mesangial cell damage in progressive renal disease. Kidney Blood Press Res 1999;22:5-12.
2. Yasuda Y, Miyata T, Nangaku M, Iida Y, Maeda K, Okubo K, et al. Functional quantitative analysis of the genome in cultured human mesangial cells. Kidney Int 1998;53:154-8.
3. Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, et al. Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. J Am Soc Nephrol 2001;12:2601-8.
4. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, et al. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature (review). J Biol Chem 2001;276:33 293-6.
5. Miyata T, Nangaku M, Suzuki D, Inagi R, Uragami K, Sakai H, et al. A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. J Clin Invest 1998;102:828-36.
6. Schick C, Kamachi Y, Bartuski AJ, Cataltepe S, Schechter NM, Pemberton PA, et al. Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. J Biol Chem 1997;272:1849-55.
7. Inagi R, Miyata T, Nangaku M, Ueyama H, Takeyama K, Kato S, et al. Transcriptional regulation of a mesangium-predominant gene, megsin. J Am Soc Nephrol 2002;13:2715-22.
8. Ye RD, Ahern SM, LeBeau MM, Lebo RV, Sadler JE. Structure of the gene from human plasminogen activator inhibitor-2. J Biol Chem 1989;264:5495-502.
9. Kruithof EK, Baker MS, Bunn C. Biological and clinical aspects of plasminogen activator inhibitor type 2. Blood 1995;86:4007-24.
10. Bachmann F. The enigma PAI-2: gene expression, evolutionary and functional aspects. Thromb Haemostasis 1995;74:172-9.
11. Bird PI. Serpins and regulation of cell death. Results Probl Cell Differ 1998;24:63-89.
12. Scott FL, Eyre HJ, Lioumi M, Ragoussis J, Irving JA, Sutherland GA, et al. Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25. Genomics 1999;62:490-9.
13. Inagi R, Miyata T, Suzuki D, Toyoda M, Wada T, Ueda Y, et al. Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy. Biochem Biophys Res Commun 2001;286:1098-106.
14. Nangaku M, Miyata T, Suzuki D, Umezono T, Hashimoto T, Wada T, et al. Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Kidney Int 2001;60:641-52.
15. Mertens PR, Harendza S, Pollock AS, Lovett DH. Glomerular mesangial cells-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1. J Biol Chem 1997;272:22 905-12.
16. Suzuki D, Miyata T, Nangaku M, Takano H, Saotome N, Inagi R, et al. Expression of megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases. J Am Soc Nephrol 1999;10:2606-13.
17. Miyata T, Inagi R, Nangaku M, Imasawa T, Sato M, Izuhara Y, et al. Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion. J Clin Invest 2002; 109:585-93.
18. Mclennan SV, Fisher E, Martell SY, Death AK, Williams PF, Lyons JG, et al. Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: possible role in diabetic nephropathy. Kidney Int 2000;58 (s77):81-7.
19. Brown NJ, Vaughan DE, Fogo AB. The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin Nephrol 2002;22:399-406.
20. Baricos WH, Cortez SL, el-Dahr SS, Schnaper HW. ECM degradation by cultured human mesangial cells is mediated by a PA/ plasmin/MMP-2 cascade. Kidney Int 1995;47:1039-47.
21. Stein PE, Carrell RW. What do dysfunctional serpins tell us about molecular mobility and disease (review)? Nat Struct Biol 1995;2:96-113.
22. Gettins P, Patston PA, Schapira M. The role of conformational change in serpin structure and function (review). Bioessays 1993;15:461-7.
23. Creighton TE, Charles IG. Sequences of the genes and polypeptide precursors for two bovine protease inhibitors. J Mol Biol 1987;194:11-22.
24. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996;97:232-7.
25. Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ. Role of oxidants and proteases in glomerular injury. Kidney Int 1994;45:352-9.
26. Davie M, Martin J, Thomas GJ, Lovett DH. Proteinases and glomerular matrix turnover. Kidney Int 1992;41:671-8.
27. Baricos WH, Shah SV. Proteolytic enzymes as mediators of glomerular injury. Kidney Int 1991;40:161-73.
28. Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH. Proteinases and the glomerulus: their role in glomerular diseases. Klin Wochenschr 1990;68:1145-9.
29. Fogo AB. The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomerulosclerosis. Am J Kidney Dis 2000;35:179-88.
30. Loskutoff DJ. A slice of PAI. J Clin Invest 1993;92:2563.
31. Nakamura S, Nakamura I, Ma L, Vaughan DE, Fogo AB. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int 2000;58:251-9.