Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: A new class of cytotoxic compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 18, 2006, Pages 4822-4825

  Hadjipavlou, Christiana ^a   Kostakis, Ioannis K ^a   Pouli, Nicole ^a   Marakos, Panagiotis ^a   Pratsinis, Harris ^b   Kletsas, Dimitris ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Aminosubstituted benzopyrano 4,3,2 c,d isoindoles; Antiproliferative activity; DNA content analysis

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG METABOLITE; ISOINDOLE DERIVATIVE; NITRACRINE; XANTHONE DERIVATIVE;

ARTICLE; CELL LINE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

CELL LINE; CELL PROLIFERATION; DNA; HUMANS; INDOLES; MOLECULAR STRUCTURE; NITRACRINE; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHENES;

EID: 33746964970     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.074     Document Type: Article

References (21)

1. Kwasniewska-Rokicinska C., Swiecki J., and Wieczorkiewicz A. Arch. Immunol. Ther. Exp. 21 (1973) 863
2. Kwasniewska-Rokicinska C., Sawicki J., and Drosik K. Mater. Med. Pol. (Engl. Ed.) 8 (1976) 289
3. Kwasniewska-Rokicinska C., and Drosik K. Mater. Med. Pol. (Engl. Ed.) 15 (1983) 43
4. Wilson W.R., Denny W.A., Twigden S.J., Baguley B.C., and Probert J.C. Br. J. Cancer 49 (1984) 215
5. Pawlak K., Matuszkiewicz A., Pawlak J.W., and Konopa J. Chem. Biol. Interact. 43 (1983) 131
6. Wilson W.R., Denny W.A., Stewart G.M., Fenn A., and Probert J.C. Int. J. Radiat. Oncol. Biol. Phys. 12 (1986) 1235
7. Gorlewska K., Mazerska Z., Sowinski P., and Konopa J. Chem. Res. Toxicol. 14 (2001) 1
8. Kolokythas G., Kostakis I.K., Pouli N., Marakos P., Kletsas D., and Pratsinis H. Bioorg. Med. Chem. 11 (2003) 4591
9. Kolokythas G., Kostakis I.K., Pouli N., Marakos P., Skaltsounis A.-L., and Pratsinis H. Bioorg. Med. Chem. Lett. 12 (2002) 1443
10. Kostakis I.K., Magiatis P., Pouli N., Marakos P., Skaltsounis A.-L., Pratsinis H., Leonce S., and Pierre A. J. Med. Chem. 45 (2002) 2599
11. Kostakis I.K., Tenta R., Pouli N., Marakos P., Skaltsounis A.-L., Pratsinis H., and Kletsas D. Bioorg. Med. Chem. Lett. 15 (2005) 5057
12. Kostakis I.K., Pouli N., Marakos P., Skaltsounis A.-L., Pratsinis H., and Kletsas D. Bioorg. Med. Chem. 14 (2006) 2910
13. Hadjipavlou C., Kostakis I.K., Pouli N., Marakos P., and Mikros E. Tetrahedron Lett. 47 (2006) 3681
14. Goldberg A.A., and Wragg A.H. J. Chem. Soc. (1958) 4227
15. Pickert M., and Frahm A.W. Arch. Pharm. 311 (1998) 177
16. Pellon R.F., Carrasco R., Milian V., and Rodes L. Synth. Commun. 25 (1995) 1077
17. Rewcastle G.W., Atwell G.J., Baguley B.C., Calveley S.B., and Denny W.A. J. Med. Chem. 32 (1989) 793
18. 3O; calcd: C, 74.74; H, 7.21; N, 13.07. Found: C, 74.97; H, 7.12; N, 12.84.
19. 3; calcd: C, 66.86; H, 5.30; N, 13.00. Found: C, 67.03; H, 5.22; N, 12.79.
20. 4O; calcd: C, 72.50; H, 7.74; N, 15.37. Found: C, 72.32; H, 7.69; N, 15.12.
21. Harker W.G., and Sikic B.I. Cancer Res. 45 (1985) 4091