Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 22, 2005, Pages 5057-5060

  Kostakis, Ioannis K ^a   Tenta, Roxane ^a,c   Pouli, Nicole ^a   Marakos, Panagiotis ^a   Skaltsounis, Alexios Leandros ^a   Pratsinis, Harris ^b   Kletsas, Dimitris ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Aminobenzopyrano 4,3,2 cd indazoles; Aminoxanthenones; Cell cycle selectivity; Cytotoxic activity; Multidrug resistance

Indexed keywords

9 METHOXYPYRAZOLOACRIDINE; AMINO ACID DERIVATIVE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMINATION; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; PYRAZOLES; XANTHENES;

EID: 25844451162     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.079     Document Type: Article

References (25)

1. H. Malonne, and G. Atassi AntiCancer Drugs 8 1997 811
2. C.J. Dunn, and K.L. Goa Drug Aging 9 1996 122
3. L.R. Wiseman, and C.M. Spencer Drug Aging 10 1997 473
4. M. Benekli, A. Kars, and N. Guler Ann. Intern. Med. 126 1997 409
5. J.D. Bailly, A. Skladanowski, A. Bettaieb, V. Mansat, A.K. Larsen, and G. Laurent Leukemia 11 1997 1523
6. H. Godas, and J.L. Mansi Cancer Treat. Rev. 21 1996 541
7. A. Liwo, D. Jeziorek, T. Ossowski, D. Dyl, A. Tempczyk, J. Tarasiuk, M. Nowaska, E. Borowski, and W. Woznicki Acta Biochim. Pol. 42 1995 445
8. S.L. Berg Crit. Rev. Oncol. Hemat. 22 1996 79
9. I. Antonini Curr. Med. Chem. 9 2002 1701
10. W.D. Klohs, R.W. Steinkampf, M.J. Havlick, and R.C. Jackson Cancer Res. 46 1986 4352
11. G. Lehne Curr. Drug Targets 1 2000 85
12. J. Tarasiuk, E. Majewska, O. Seksek, D. Rogacka, I. Antonini, A. Garnier-Suillerot, and E. Borowski Biochem. Pharmacol. 68 2004 1815
13. A.A. Adjei Invest New Drugs 17 1999 43
14. D.B. Capps, J. Dunbar, S.R. Kesten, J.L. Shillis, L.M. Werbel, J. Plowman, and D.L. Ward J. Med. Chem. 35 1992 4770
15. N. Keshelava, D. Tsao-Wei, and C.P. Reynolds AntiCancer Drug Des. 14 1999 451
16. A.A. Adjei, M. Charron, E.K. Rowinski, P.A. Svingen, J. Miller, J.M. Reid, J. Sebold-Leopold, M.M. Ames, and S.H. Kaufmann Cancer Res. 4 1998 683
17. Y. Hu, A. Krishan, W.J. Nie, K.S. Sridhar, L.D. Mayer, and M. Bally Clin. Cancer Res 10 2004 1160
18. I.K. Kostakis, K. Ghirtis, N. Pouli, P. Marakos, A.L. Skaltsounis, S. Leonce, D.H. Gaignard, and G. Atassi Il Farmaco 55 2000 455
19. G. Kolokythas, I.K. Kostakis, N. Pouli, P. Marakos, A.L. Skaltsounis, and H. Pratsinis Bioorg. Med. Chem. Lett. 12 2002 1443
20. G. Kolokythas, I.K. Kostakis, N. Pouli, P. Marakos, D. Kletsas, and H. Pratsinis Bioorg. Med. Chem 11 2003 4591
21. I. Kostakis, P. Magiatis, N. Pouli, P. Marakos, A.L. Skaltsounis, H. Pratsinis, S. Leonce, and A. Pierre J. Med. Chem. 45 2002 2599
22. C.D. Gabbutt, J.D. Hepworth, M.W.J. Urquhart, and L.M. Vazquez de Miguel J. Chem. Soc., Perkin Trans. 1 1997 1819
23. W.G. Harker, and B.I. Sikic Cancer Res. 45 1985 4091
24. J.L. Grem, P.M. Politi, S.L. Berg, N.M. Benchekroun, M. Patel, F. Balis, B.K. Sinha, W. Dahut, and C. Allegra J. Biochem. Pharmacol. 51 1996 1649
25. F. Traganos, D.P. Evenson, L. Staiano-Coico, Z. Darzynkiewicz, and M.R. Melamed Cancer Res. 40 1980 671