Aging is neuroprotective during global ischemia but leads to increased caspase-3 and apoptotic activity in hippocampal neurons

Current Neurovascular Research

Volumn 3, Issue 3, 2006, Pages 181-186

  He, Zhen ^a   Meschia, James F ^a   Brott, Thomas G ^a   Dickson, Dennis W ^a   Mckinney, Michael ^a  

^a MAYO CLINIC   (United States)

Author keywords

Aging; Caspase 3 TUNEL dual labeling; Experimental cerebral ischemia; Neuroprotection; TUNEL

Indexed keywords

CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL COUNT; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASPASE 3; CASPASES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; NEURONS; RATS; RATS, INBRED F344;

EID: 33746920022     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720206778018802     Document Type: Article

References (32)

1. Bonde, C, Noraberg, J, Noer, H, Zimmer, J. (2005) Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures. Neuroscience 136: 779-794.
2. Chen, J, Nagayama, T, Jin, K, Stetler, RA, Zhu, RL, Graham, SH, Simon, RP. (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18: 4914-4928.
3. Chong, ZZ, Li, F, Maiese, K. (2006) Group I Metabotropic Receptor Neuroprotection Requires Akt and Its Substrates that Govern FOXO3a, Bim, and beta-Catenin During Oxidative Stress. Curr Neurovasc Res 3: 107-117.
4. Degterev, A, Huang, Z, Boyce, M, Li, Y, Jagtap, P, Mizushima, N, Cuny, GD, Mitchison, TJ, Moskowitz, MA, Yuan, J. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1: 112-119.
5. Hara, A, Niwa, M, Iwai, T, Nakashima, M, Bunai, Y, Uematsu, T, Yoshimi, N, Mori, H. (1999) Neuronal apoptosis studied by a sequential TUNEL technique: a method for tract-tracing. Brain Res Brain Res Protoc 4: 140-146.
6. Hengartner, MO. (2000) The biochemistry of apoptosis. Nature 407: 770-776.
7. He, Z, He, YJ, Day, AL, Simpkins, JW. (2002) Proestrus Levels of Estradiol during Transient Global Cerebral ischemia Improves Histological Outcome of the Hippocampal CA1 Region: Perfusion-Dependent and - Independent Mechanisms. J Neurol Sci 193: 79-87.
8. He, Z, Crook, JE, Meschia, JF, Brott, TG, Dickson, DW, Mickinney, M. (2005a) Aging Blunts Ischemic-Preconditioning-Induced Neuroprotection Following Transient Global Ischemia in Rats. Curr Neurovasc Res 2: 365-374.
9. He, Z, Cui, L, Wu, SS, Li, XY, Simpkins, JW, Mckinney, M, Day, AL. (2004) Increased severity of acute cerebral ischemic injury correlates with enhanced stem cell induction as well as with predictive behavioral profiling. Curr Neurovasc Res 1: 399-409.
10. He, Z, Cui, L, Meschia, J, Dickson, DW, Brott, TG, Simpkins, JW, Day, AL, Mckinney, M. (2005b) Hippocampal progenitor cells express nestin following cerebral ischemia in rats. NeuroReport 16: 1541-1544.
11. Jaekel, B, Muhlberg, K, Garcia de Arriba, S, Reichenbach, A, Verdaguer, E, Pallas, M, Camins, A, Norenberg, W, Allgaier, C. (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Br J Pharmacol 147: 622-633.
12. Jarskog, LF, Gilmore, JH, Glantz, LA, Gable, KL, German, TT, Tong, RI, Lieberman, JA. (2006) Caspase-3 Activation in Rat Frontal Cortex Following Treatment with Typical and Atypical Antipsychotics. Neuropsychopharmacology. Apr 12.
13. Kaufmann, JA, Bickford, PC, Taglialatela, G. (2002) Free radical-dependent changes in constitutive Nuclear factor kappa B in the aged hippocampus. Neuroreport 13: 1917-1920.
14. Lo, EH, Dalkara, T, Moskowitz, MA. (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4: 399-415.
15. Lu, T, Pan, Y, Kao, SY, Li, C, Kohane, I, Chan, J, Yankner, BA. (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429: 883-891
16. Martinez-Lara, E, Canuelo, AR, Siles, E, Hernandez, R, Del Moral, ML, Blanco, S, Pedrosa, JA, Rodrigo, J, Peinado, MA. (2005) Constitutive nitric oxide synthases are responsible for the nitric oxide production in the ischemic aged cerebral cortex. Brain Res 1054: 88-94.
17. McLaughlin, B, Hartnett, KA, Erhardt, JA, Legos, JJ, White, RF, Barone, FC, Aizenman, E. (2003) Caspase 3 activation is essential for neuroprotection in preconditioning. Proc Natl Acad Sci USA 100: 715-720.
18. Miller, TM, Moulder, KL, Knudson, CM, Creedon, DJ, Deshmukh, M, Korsmeyer, SJ, Johnson, EM Jr. (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139: 205-217.
19. Namura, S, Zhu, J, Fink, K, Endres, M, Srinivasan, A, Tomaselli, KJ, Yuan, J, Moskowitz, MA. (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 18:3659-3668.
20. Niquet, J, Seo, DW, Allen, SG, Wasterlain, CG. (2006) Hypoxia in presence of blockers of excitotoxicity induces a caspase-dependent neuronal necrosis. Neuroscience May 10. [Epub ahead of print].
21. Oomman, S, Finckbone, V, Dertien, J, Attridge, J, Henne, W, Medina, M, Mansouri, B, Singh, H, Strahlendorf, H, Strahlendorf, J. (2004) Active caspase-3 expression during postnatal development of rat cerebellum is not systematically or consistently associated with apoptosis. J Comp Neurol 476: 154-173.
22. Saransaari, P, Oja, SS. (2000) Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus. Neurochem Res 25: 1067-1072.
23. Slee, EA, Adrain, C, Martin, SJ. (1999) Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ 6: 1067-1074.
24. Slee, EA, Adrain, C, Martin, SJ. (2001) Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276: 7320-7326.
25. Suzuki, Y, Takagi, Y, Nakamura, R, Hashimoto, K, Umemura, K. (2003) Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats. Brain Res 964: 116-120.
26. Sutherland, GR, Dix, GA, Auer, RN. (1996) Effect of age in rodent models of focal and forebrain ischemia. Stroke 27: 1663-1667.
27. Tanaka, H, Yokota, H, Jover, T, Cappuccio, I, Calderone, A, Simionescu, M, Bennett, MV, Zukin, RS. (2004) Ischemic preconditioning: neuronal survival in the face of caspase-3 activation. J Neurosci 24: 2750-2759.
28. Unal-Cevik, I, Kilinc, M, Can, A, Gursoy-Ozdemir, Y, Dalkara, T. (2004) Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 35: 2189-2194.
29. Wei, L, Ying, D-J, Cui, L, Langsdorf, J, Yu, SP. (2004) Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats. Brain Res 1022: 54-61.
30. Xifro, X, Falluel-Morel, A, Minano, A, Aubert, N, Fado, R, Malagelada, C, Vaudry, D, Vaudry, H, Gonzalez, B, Rodriguez-Alvarez, J. (2006) N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells. J Biol Chem 281: 6801-6812.
31. Yamashima, T. (2000) Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62:273-295.
32. Yuan, J, Lipinski, M, Degterev, A. (2003) Diversity in the mechanisms of neuronal cell death. Neuron 40: 401-413.