A case of severe diffuse venous thromboembolism associated with aprotinin and hypothermic circulatory arrest in a cardiac surgical patient with factor V Leiden

Anesthesiology

Volumn 105, Issue 1, 2006, Pages 219-221

  Shore Lesserson, Linda ^a,b   Reich, David L ^a  

^a Department of Anesthesiology ^*  (United States)

^b MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTIFIBRINOLYTIC AGENT; APROTININ; BLOOD CLOTTING FACTOR 5 LEIDEN; HEPARIN; BLOOD CLOTTING FACTOR 5;

ADULT; AORTA GRAFT; AORTA STENOSIS; AORTA VALVE REPLACEMENT; ARTICLE; BLOOD CLOTTING DISORDER; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CASE REPORT; CAUSE OF DEATH; CRYOPRECIPITATION; DISEASE SEVERITY; HEART ARREST; HEART PACING; HEART VENTRICLE ARRHYTHMIA; HUMAN; INDUCED HYPOTHERMIA; INTRACARDIAC THROMBOSIS; MALE; NERVE BLOCK; OXYGEN THERAPY; PLASMA TRANSFUSION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RESUSCITATION; SURGICAL PATIENT; THROMBOCYTE TRANSFUSION; VENOUS THROMBOEMBOLISM; CHEMICALLY INDUCED DISORDER; DEEP HYPOTHERMIC CIRCULATORY ARREST; FATALITY; GENETICS; HEART SURGERY; MIDDLE AGED; THROMBOEMBOLISM;

APROTININ; CARDIAC SURGICAL PROCEDURES; CIRCULATORY ARREST, DEEP HYPOTHERMIA INDUCED; FACTOR V; FATAL OUTCOME; HUMANS; MALE; MIDDLE AGED; THROMBOEMBOLISM;

EID: 33746914748     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200607000-00034     Document Type: Article

References (29)

1. Levi M, Cromheecke ME, de Jonge E, Prins MH, de Mol BJ, Briet E, Buller HR: Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints. Lancet 1999; 354:1940-7
2. Munoz JJ, Birkmeyer NJ, Birkmeyer JD, O'Connor GT, Dacey LJ: Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery? A meta-analysis. Circulation 1999; 99:81-9
3. Fanashawe MP, Shore-Lesserson L, Reich DL: Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest. ANESTHESIOLOGY 2001; 95:1525-7
4. Royston D, Bidstrup BP, Taylor KM, Sapsford RN: Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 1987; 2:1289-91
5. Laupacis A, Fergusson D: Drugs to minimize perioperative blood loss in cardiac surgery: Meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators. Anesth Analg 1997; 85:1258-67
6. Bennett-Guerrero E, Sorohan JG, Gurevich ML, Kazanjian PE, Levy RR, Barbera AV, White WD, Slaughter TF, Sladen RN, Smith PK, Newman MF: Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: A randomized, blinded clinical trial. ANESTHESIOLOGY 1997; 87:1373-80
7. Shore-Lesserson L, Reich DL, Silvay G, Griepp RB: Hemostasis in aortic and cardiothoracic surgery. J Card Surg 1997; 12:232-7
8. Landymore RW, Murphy JT, Lummis H, Carter C: The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations (letter). Eur J Cardiothorac Surg 1997; 11:798-800
9. Sundt TMD, Kouchoukos NT, Saffitz JE, Murphy SF, Wareing TH, Stahl DJ: Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest. Ann Thorac Surg 1993; 55:1418-24
10. Heindel SMM, Freid E, Valley R, White G, Norfleet E: Fatal thrombosis associated with a hemi-Fontan procedure, heparin-protamine reversal, and aprotinin. ANESTHESIOLOGY 2001; 94:369-71
11. Okita Y, Takamoto S, Ando M, Morota T, Yamaki F, Matsukawa R, Kawashima Y: Coagulation and fibrinolysis system in aortic surgery under deep hypothermic circulatory arrest with aprotinin: The importance of adequate heparinization. Circulation 1997; 96:II-376-81
12. Parolari A, Antona C, Alamanni F, Spirito R, Naliato M, Gerometta P, Arena V, Biglioli P: Aprotinin and deep hypothermic circulatory arrest: There are no benefits even when appropriate amounts of heparin are given. Eur J Cardiothorac Surg 1997; 11:149-56
13. Westaby S: Coagulation disturbance in profound hypothermia: The influence of anti- fibrinolytic therapy. Semin Thorac Cardiovasc Surg 1997; 9:246-56
14. Eaton MP, Deeb GM: Aprotinin versus epsilon-aminocaproic acid for aortic surgery using deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth 1998; 12:548-52
15. Mora Mangano CT, Neville MJ, Hsu PH, Mignea I, King J, Miller DC: Aprotinin, blood loss, and renal dysfunction in deep hypothermic circulatory arrest. Circulation 2001; 104:I276-81
16. Rooney SJ, Pagano D, Bognolo G, Wong C, Bonser RS: Aprotinin in aortic surgery requiring profound hypothermia and circulatory arrest. Eur J Cardiothorac Surg 1997; 11:373-8
17. Smith CR, Spanier TB: Aprotinin in deep hypothermic circulatory arrest. Ann Thorac Surg 1999; 68:278-86
18. Royston D: A case for aprotinin in patients having deep hypothermic circulatory arrest. J Card Surg 1997; 12:214-20
19. Robbins P, Forrest M, Fanning S, Royston D: Use of aprotinin therapy in a patient with factor V Leiden. Anesth Analg 1997; 84:694-8
20. Sweeney JD, Blair AJ, Dupuis MP, King TC, Moulton AL: Aprotinin, cardiac surgery, and factor V Leiden. Transfusion 1997; 37:1173-8
21. Donahue BS, Gailani D, Higgins MS, Drinkwater DC, George ALJ: Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation 2003; 107:1003-8
22. Varela ML, Adamczuk YP, Martinuzzo ME, Forastiero RR, Klein FR, Rossi AS, Carreras LO: Early occlusion of coronary by-pass associated with the presence of factor V Leiden and the prothrombin 20210A allele: Case report. Blood Coagul Fibrinolysis 1999; 10:443-6
23. Heijmans BT, Westendorp RG, Knook DL, Kluft C, Slagboom PE: The risk of mortality and the factor V Leiden mutation in a population-based cohort. Thromb Haemost 1998; 80:607-9
24. Cushman M, Rosendaal FR, Psaty BM, Cook EF, Valliere J, Kuller LH, Tracy RP: Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: Results from the Cardiovascular Health Study. Thromb Haemost 1998; 79:912-5
25. Donahue BS, Factor V: Leiden and perioperative risk. Anesth Analg 2004; 98:1623-34
26. Rosendaal FR, Siscovick DS, Schwartz SM, Beverly RK, Psaty BM, Longstreth WT Jr, Raghunathan TE, Koepsell TD, Reitsma PH: Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89:2817-21
27. Reiner AP, Rosendaal FR, Reitsma PH, Lemaitre RN, Pearce RM, Friedlander Y, Raghunathan TE, Psaty BM, Siscovick DS: Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons. Am J Cardiol 2002; 90:66-8
28. Kiechl S, Muigg A, Santer P, Mitterer M, Egger G, Oberhollenzer M, Oberhollenzer F, Mayr A, Gasperi A, Poewe W, Willeit J: Poor response to activated protein C as a prominent risk predictor of advanced atherosclerosis and arterial disease. Circulation 1999; 99:614-9
29. Donahue BS: Thrombosis after deep hypothermic circulatory arrest with antifibrinolytic therapy: Is factor V Leiden the smoking gun? ANESTHESIOLOGY 2002; 97:760-1