Interleukin 2 regulation following semi-allogeneic bone marrow transplantation in mice

Cancer Immunology, Immunotherapy

Volumn 55, Issue 11, 2006, Pages 1330-1336

  Abdul Hai, Ali ^a   Ben Yehuda, Arie ^b   Galsky, Haya ^b   Slavin, Shimon ^a   Or, Reuven ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

Immune function; Interleukin 2; Marrow transplantation; Mice; Spleen; Thymus

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DONOR; FEMALE; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOREGULATION; IMMUNOTHERAPY; INFECTION SENSITIVITY; LYMPHOCYTE COUNT; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; T LYMPHOCYTE; WHOLE BODY RADIATION;

ANIMALS; BONE MARROW TRANSPLANTATION; FEMALE; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; INTERLEUKIN-2; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHENOTYPE; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS;

EID: 33746877837     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-006-0125-y     Document Type: Article

References (29)

1. Alpdogan O, Schmaltz C, Muriglan SJ, Kappel BJ, Perales MA, Rotolo JA, Halm JA, Rich BE, van den Brink MR (2001) Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98(7):2256-2265
2. Alyea EP, Weller E, Fisher DC, Freedman AS, Gribben JG, Lee S, Schlossman RL, Stone RM, Friedberg J, DeAngelo D, Liney D, Windawi S, Ng A, Mauch P, Antin JH, Soiffer RJ (2002) Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 8(11):601-607
3. Andre-Schmutz I, Bonhomme D, Yates F, Malassis M, Selz F, Fischer A, Cavazzana-Calvo M (2004) IL-7 effect on immunological reconstitution after HSCT depends on MHC incompatibility. Br J Haematol 126(6):844-851
4. Atkinson K (1990) Reconstitution of the haematopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 5:209-226
5. Bolotin E, Smogorzewska M, Smith S, Widmer M, Weinberg K (1996) Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 88(5):1887-1894
6. Bornhauser M, Theuser C, Soucek S, Holig K, Klingebiel T, Blau W, Fauser A, Runde V, Schwinger W, Rutt C, Ehninger G (2000) Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysis. Haematologica 85(8):839-847
7. Bruserud O, Ehninger G, Hamann W, Pawelec G (1993) Secretion of IL-2, IL-3, IL-4, IL-6 and GM-CSF by CD4+ and CD8+ TCR alpha beta+ T-cell clones derived early after allogeneic bone marrow transplantation. Scand J Immunol 38(1):65-74
8. Cote-Sierra J, Foucras G, Guo L, Chiodetti L, Young HA, Hu-Li J, Zhu J, Paul WE (2004) Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci USA 101(11):3880-3885
9. Ellison CA, Natuik SA, Fischer JM, McIntosh AR, Scully SA, Bow EJ, Danilenko DM, Hayglass KT, Gartner JG (2004) Effect of recombinant human keratinocyte growth factor (rHuKGF) on the immunopathogenesis of intestinal graft-vs.-host disease induced without a preconditioning regimen. J Clin Immunol 24(2):197-211
10. Godthelp BC, van Tol MJ, Vossen JM, van Den Elsen PJ (1999) T-Cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell-depleted or unmanipulated grafts: evaluation of overall and antigen-specific T-cell repertoires. Blood 94(12):4358-4369
11. Hartwig UF, Robbers M, Wickenhauser C, Huber C (2002) Murine acute graft-versus-host disease can be prevented by depletion of alloreactive T lymphocytes using activation-induced cell death. Blood 99(8):3041-3049
12. Lee CK, deMagalhaes-Silverman M, Hohl RJ, Hayashi M, Buatti J, Wen BC, Schlueter A, Strauss RG, Gingrich RD (2003) Donor T-lymphocyte infusion for unrelated allogeneic bone marrow transplantation with CD3+ T-cell-depleted graft. Bone Marrow Transplant 31(2):121-128
13. Mills GB, Cheung RK, Grinstein S, Gelfand EW (1985) Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor. J Immunol 134:1640-1643
14. Morecki S, Gelfand Y, Nagler A, Or R, Naparstek E, Varadi G, Engelhard D, Ackerstein A, Slavin S (2001) Immune reconstitution following allogeneic stem cell transplantation in recipients conditioned by low intensity vs myeloablative regimen. Bone Marrow Transplant 28(3):243-9
15. Noort WA, Benner R, Savelkoul HF (1996) Differential effectiveness of anti-CD8 treatment on ongoing graft-versus-host reactions in mice. Transpl Immunol 4(3):198-202
16. Parkman R (1994) Immunological reconstitution following bone marrow transplantation. In: Forman SJ, Blume KG, Donnall Thomas E (eds) Bone marrow transplantation. Blackwell, Boston pp 505-512
17. Pelot MR, Pearson DA, Swenson K, Zhao G, Sachs J, Yang YG, Sykes M (1999) Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen. Biol Blood Marrow Transplant 5(3):133-143
18. Porrata LF, Markovic SN (2004) Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation. Clin Exp Med 4(2):78-85
19. de la Rosa M, Rutz S, Dorninger H, Scheffold A (2004) Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 34(9):2480-2488
20. Rossi S, Blazar BR, Farrell CL, Danilenko DM, Lacey DL, Weinberg KI, Krenger W, Hollander GA (2002) Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood 100(2):682-691
21. Schots R, Van Riet I, Ben Othman T, Trullemans F, De Waele M, Van Camp B (2001) The impact of partial T cell depletion on overall transplant-related toxicity, graft function and survival after HLA-identical allogeneic bone marrow transplantation in standard risk adult patients with leukemia. Bone Marrow Transplant 28(10):917-922
22. Slavin S, Waldmann H, Or R, Cividalli G, Naparstek E, Steiner-Salz D, Michaeli J, Galun E, Weiss L, Samuel S, Morecki S, Bar S, Brautbar C, Weshler Z, Hale G, Rachmilewitz EA, Reisner Y (1985) Prevention of graft vs host disease in allogeneic bone marrow transplantation for leukemia by T cell depletion in vitro prior to transplantation. Transplant Proc 17:465-467
23. Thomas D, Vadas M, Lopez A (2004) Regulation of haematopoiesis by growth factors - emerging insights and therapies. Expert Opin Biol Ther 4(6):869-879
24. Truitt RL, Atasoylu AA (1991) Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. Bone Marrow Transplant 8(1):51-58
25. Vourka-Karussis U, Ackerstein A, Pugatsch T, Slavin S (1999) Allogeneic cell-mediated immunotherapy for eradication of minimal residual disease: comparison of T-cell and IL-2 activated killer (LAK) cell-mediated adoptive immunotherapy in murine models. Exp Hematol 27(3):461-469
26. Waldmann H, Polliack A, Hale G, Or R, Cividalli G, Weiss L, Weshler Z, Samuel S, Manor D, Brautbar C, Rachmilewitz EA, Slavin S (1984) Elimination of graft-versus-host disease by invitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet 2:483-486
27. Wang MG, Szebeni J, Pearson DA, Szot GL, Sykes M (1995) Inhibition of graft-versus-host disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4+ helper cells. Transplantation 15:60
28. West F, Mitchell SA (2004) Evidence-based guidelines for the management of neutropenia following outpatient hematopoietic stem cell transplantation. Clin J Oncol Nurs 8(6):601-613
29. Abdul-Hai A, Lorberboum-Gliski H, Mechushtan A, Weiss L, Slavin S, Or R. (1995) Involvement of interleukin-2 in immunologic reconstitution following bone marrow transplantation in mice. J Interferon Cytokine Res 15:95-101