Parecoxib impairs early metaphyseal bone healing in rats

Archives of Orthopaedic and Trauma Surgery

Volumn 126, Issue 7, 2006, Pages 433-436

  Meunier, Andreas ^a   Aspenberg, Per ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Bone; Cyclooxygenase inhibitors; Fracture healing; Parecoxib; Rats

Indexed keywords

PARECOXIB; STAINLESS STEEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE SCREW; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFICACY; DRUG METABOLISM; DRUG RELEASE; FEMALE; FRACTURE FIXATION; FRACTURE NONUNION; MALE; METAPHYSIS; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RIGIDITY; STATISTICAL SIGNIFICANCE;

ANIMALS; CYCLOOXYGENASE INHIBITORS; FEMALE; FRACTURE HEALING; ISOXAZOLES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33746875639     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00402-006-0160-3     Document Type: Article

References (21)

1. Altman RD et al (1995) Effect of nonsteroidal antiinflammatory drugs on fracture healing: A laboratory study in rats. J Orthop Trauma 9(5):392-400
2. Aspenberg P (2002) Avoid cox inhibitors after skeletal surgery! Acta Orthop Scand 73(5):489-490
3. Beck A et al (2003) Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg 123(7):327-332
4. Brown KM et al (2004) Effect of COX-2-specific inhibition on fracture healing in the rat femur. J Bone Joint Surg Am 86-A(1):116-123
5. Camu FL Shi, Vanlersberghe C (2003) The role of COX-2 inhibitors in pain modulation. Drugs 63(Suppl 1):1-7
6. Dahners LE, Mullis BH (2004) Effects of nonsteroidal anti-inflammatory drugs on bone formation and soft-tissue healing. J Am Acad Orthop Surg 12(3):139-143
7. Einhorn TA (2003) Cox-2: Where are we in 2003? The role of cyclooxygenase-2 in bone repair. Arthritis Res Ther 5(1):5-7
8. Endo K et al (2002) Cyclooxygenase-2 inhibitor inhibits the fracture healing. J Physiol Anthropol Appl Human Sci 21(5):235-258
9. Gajraj NM (2003) The effect of cyclooxygenase-2 inhibitors on bone healing. Reg Anesth Pain Med 28(5):456-465
10. Gerstenfeld LC et al (2003) Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res 21(4):670-5
11. Goodman S et al (2002) COX-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res 20(6):1164-1169
12. Halpin RA et al (2000) The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs. Drug Metab Dispos 28(10):1244-54
13. Jacobsson SA et al (1994) Effect of diclofenac on fixation of hydroxyapatite-coated implants. An experimental study. J Bone Joint Surg Br 76(5):831-833
14. Kjaersgaard-Andersen P, Jensen K (2003) Cox inhibitors and bone healing. Acta Orthop Scand 74(2): 230-1; author reply 231
15. Long J et al (2002) The effect of cyclooxygenase-2 inhibitors on spinal fusion. J Bone Joint Surg Am 84-A(10):1763-8
16. Paulson SK et al (2000) Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats. Drug Metab Dispos 28(5):514-21
17. Persson P-E (2004) Heterotopic ossification: Clinical and experimental studies on risk factors, etiology and inhibition by non-steroidal anti-inflammatory drugs. Medical Dissertation, University Uppsala, Sweden
18. Riew KD et al (2003) Time-dependent inhibitory effects of indomethacin on spinal fusion. J Bone Joint Surg Am 85-A(4):632-4
19. Simon AM, Manigrasso MB, O'Connor JP (2002) Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 17(6):963-76
20. Skoglund B, Holmertz J, Aspenberg P (2004) Systemic and local ibandronate enhance screw fixation. J Orthop Res 22(5):1108-13
21. Zhang X et al (2002) Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109(11):1405-15