Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 18, 2006, Pages 4728-4732

  Ellis, Christopher D ^a   Oppong, Kofi A ^a   Laufersweiler, Michael C ^a   O'Neil, Steven V ^a   Soper, David L ^a   Wang, Yili ^a   Wos, John A ^a   Fancher, Amy N ^a   Lu, Wei ^a   Suchanek, Maureen K ^a   Wang, Richard L ^a   De, Biswanath ^a   Demuth Jr , Thomas P ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Caspase 1; ICE; Interleukin 1 ; Peptidomimetic; Thiazepine

Indexed keywords

CASPASE 3; CASPASE 8; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; PRALNACASAN; THIAZEPINE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; MOLECULAR MODEL; STRUCTURE ANALYSIS;

CASPASE 1; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

EID: 33746794165     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.016     Document Type: Article

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