An intersheet packing interaction in Aβ fibrils mapped by disulfide cross-linking

Biochemistry

Volumn 43, Issue 49, 2004, Pages 15310-15317

  Shivaprasad, Shankaramma ^a   Wetzel, Ronald ^a  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOCHEMISTRY; CONFORMATIONS; CROSSLINKING; HYDROGEN BONDS; MOLECULAR STRUCTURE; MONOMERS; MUTAGENESIS; OXIDATION; SULFUR COMPOUNDS;

AΒ FIBRILS; AMYLOID; CROSS-SEEDING; CYSTEINE;

PROTEINS;

AMYLOID; CYSTEINE; DISULFIDE; LEUCINE; MONOMER; MUTANT PROTEIN; PEPTIDE DERIVATIVE;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; CROSS LINKING; FIBER; PLASTICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANTIBODIES, MONOCLONAL; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; THIAZOLES;

EID: 10644252759     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048019s     Document Type: Article

References (29)

1. Martin, J. B. (1999) Molecular basis of the neurodegenerative disorders, N. Engl. J. Med. 340, 1970-1980 [erratum: (1999) N. Engl. J. Med. 341, 1407].
2. Sipe, J. D., and Cohen, A. S. (2000) Review: history of the amyloid fibril, J. Struct. Biol. 130, 88-98.
3. O'Nuallain, B., and Wetzel, R. (2002) Conformational antibodies recognizing a generic amyloid fibril epitope, Proc. Natl. Acad. Sci. U.S.A. 99, 1485-1490.
4. Caughey, B., and Lansbury, P. T. (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders, Annu. Rev. Neurosci. 26, 267-298.
5. Kheterpal, I., Lashuel, H. A., Hartley, D. M., Walz, T., Lansbury, P. T., Jr., and Wetzel, R. (2003) Abeta protofibrils possess a stable core structure resistant to hydrogen exchange, Biochemistry 42, 14092-14098.
6. Sunde, M., and Blake, C. (1997) The structure of amyloid fibrils by electron microscopy and X-ray diffraction, Adv. Protein Chem. 50, 123-159.
7. Torok, M., Milton, S., Kayed, R., Wu, P., McIntire, T., Glabe, C. G., and Langen, R. (2002) Structural and dynamic features of Alzheimer's abeta peptide in amyloid fibrils studied by site-directed spin labeling, J. Biol. Chem. 277, 40810-40815.
8. Kheterpal, I., Williams, A., Murphy, C., Bledsoe, B., and Wetzel, R. (2001) Structural features of the Aβ amyloid fibril elucidated by limited proteolysis, Biochemistry 40, 11757-11767.
9. Williams, A. D., Portelius, E., Kheterpal, I., Guo, J. T., Cook, K. D., Xu, Y., and Wetzel, R. (2004) Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis, J. Mol. Biol. 335, 833-842.
10. Benzinger, T. L., Gregory, D. M., Burkoth, T. S., Miller-Auer, H., Lynn, D. G., Botto, R. E., and Meredith, S. C. (1998) Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register, Proc. Natl. Acad. Sci. U.S.A. 95, 13407-13412.
11. Petkova, A. T., Ishii, Y., Balbach, J. J., Antzutkin, O. N., Leapman, R. D., Delaglio, F., and Tycko, R. (2002) A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid-state NMR, Proc. Natl. Acad. Sci. U.S.A. 99, 16742-16747.
12. Guo, J.-T., Wetzel, R., and Xu, Y. (2004) Molecular modeling of the core of Aβ amyloid fibrils, Proteins 57, 357-364.
13. Naiki, H., Higuchi, K., Hosokawa, M., and Takeda, T. (1989) Fluorometric determination of amyloid fibrils in vitro using the fluorscent dye, thioflavine T, Anal. Biochem. 177, 244-249.
14. LeVine, H. (1999) Quantification of β-sheet amyloid fibril structures with thioflavin T, Methods Enzymol. 309, 274-284.
15. Means, G. E., and Feeney, R. E. (1971) Chemical Modification of Proteins, Holden-Day, San Francisco.
16. Harper, J. D., and Lansbury, P. T., Jr. (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins, Annu. Rev. Biochem. 66, 385-407.
17. O'Nuallain, B., Williams, A. D., Westermark, P., and Wetzel, R. (2004) Seeding specificity in amyloid growth induced by heterologous fibrils, J. Biol. Chem. 279, 17490-17499.
18. Wood, S. J., Chan, W., and Wetzel, R. (1996) Seeding of Aβ fibril formation is inhibited by all three isotypes of apolipoprotein E, Biochemistry 35, 12623-12628.
19. Kheterpal, I., Zhou, S., Cook, K. D., and Wetzel, R. B. (2000) A-beta amyloid fibrils possess a core structure highly resistant to hydrogen exchange, Proc. Natl. Acad. Sci. U.S.A. 97, 13597-13601.
20. Hou, L., Shao, H., Zhang, Y., Li. H., Menon, N. K., Neuhaus, E. B., Brewer, J. M., Byeon, I. J., Ray, D. G., Vitek, M. P., Iwashita, T., Makula, R. A., Przybyla, A. B., and Zagorski, M. G. (2004) Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation, J. Am. Chem. Soc. 126, 1992-2005.
21. Wetzel, R. (1987) Harnessing disulfide bonds using protein engineering, Trends Biochem. Sci. 12, 478-482.
22. Betz, S. F. (1993) Disulfide bonds and the stability of globular proteins, Protein Sci. 2, 1551-1558.
23. Kajava, A. V., Baxa, U., Wickner, R. B., and Steven, A. C. (2004) A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structure, Proc. Natl. Acad. Sci. U.S.A. 101, 7885-7890.
24. Thornton, J. M. (1981) Disulphide bridges in globular proteins, J. Mol. Biol. 151, 261-287.
25. Hilbich, C., Kisters, W. B., Reed, J., Masters, C. L., and Beyreuther, K. (1991) Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease, J. Mol. Biol. 218, 149-163.
26. Tanaka, M., Chien, P., Naber, N., Cooke, R., and Weissman, J. S. (2004) Conformational variations in an infectious protein determine prion strain differences, Nature 428, 323-328.
27. Liou, Y. C., Tocilj, A., Davies, P. L., and Jia, Z. (2000) Mimicry of ice structure by surface hydroxyls and water of a beta-helix antifreeze protein. Nature 406, 322-324.
28. Wetzel, R. (2002) Ideas of order for amyloid fibril structure, Structure 10, 1031-1036.
29. Jimenez, J. L., Nettleton, E. J., Bouchard, M., Robinson, C. V., Dobson, C. M., and Saibil, H. R. (2002) The protofilament structure of insulin amyloid fibrils, Proc. Natl. Acad. Sci. U.S.A. 99, 9196-9201.