Development of dosage design of hepatic metabolizing drugs using serum albumin level in chronic hepatic failure

Biological and Pharmaceutical Bulletin

Volumn 29, Issue 8, 2006, Pages 1692-1699

  Mano, Yasunari ^a,b   Tsukada, Hirotaka ^b   Kurihara, Takeshi ^b   Nomura, Masaaki ^b   Yokogawa, Koichi ^b   Miyamoto, Ken Ichi ^b  

^a INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Chronic hepatic failure; Disposition kinetics; Dosage design; Low high hepatic extraction drug; Serum albumin concentration

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; CHLORZOXAZONE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; LIDOCAINE; PROPRANOLOL; PROPRANOLOL DERIVATIVE; SERUM ALBUMIN; TOLBUTAMIDE; ZONISAMIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOSE CALCULATION; DOSE LIVER FUNCTION RELATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER FAILURE; LIVER FUNCTION; LIVER METABOLISM; MEAN RESIDENCE TIME; NONHUMAN; OPTIMAL DRUG DOSE; PLASMA PROTEIN BINDING; RAT; TREATMENT PLANNING;

ANIMALS; CARBON TETRACHLORIDE; CHRONIC DISEASE; LIVER; LIVER FAILURE; MALE; PROTEIN BINDING; RATS; RATS, WISTAR; SERUM ALBUMIN;

EID: 33746676925     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.29.1692     Document Type: Article

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