Long lasting effects of prenatal exposure to deltamethrin on cerebral and hepatic cytochrome P450s and behavioral activity in rat offspring

European Journal of Pharmacology

Volumn 544, Issue 1-3, 2006, Pages 58-68

  Johri, Ashu ^a   Yadav, Sanjay ^a   Singh, Ram L ^b   Dhawan, Alok ^a   Ali, Mohd ^a   Parmar, Devendra ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b Dr RML Avadh University   (India)

Author keywords

(Rat); Behavioral activity; Cytochrome P450; Deltamethrin; Expression; Gestation

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; DELTAMETHRIN; DIMETHYLNITROSAMINE DEMETHYLASE; ETHOXYRESORUFIN DEETHYLASE; ISOENZYME; PENTOXYRESORUFIN DEALKYLASE; PYRETHROID;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BRAIN; FEMALE; GENE EXPRESSION; GESTATION PERIOD; LIVER; LOCOMOTION; MALE; NONHUMAN; ONTOGENY; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BEHAVIOR, ANIMAL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INSECTICIDES; LIVER; MALE; MATERNAL EXPOSURE; N-METHYLASPARTATE; NITRILES; PREGNANCY; PYRETHRINS; RATS; RATS, WISTAR; TELENCEPHALON;

EID: 33746610909     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.06.042     Document Type: Article

References (57)

1. Agrawal A.K., and Shapiro B.H. Imprinted overinduction of hepatic CYP2B1 and 2B2 in adult rats neonatally exposed to phenobarbital. J. Pharmacol. Exp. Ther. 279 (1996) 991-999
2. Agrawal A.K., and Shapiro B.H. Latent overexpression of hepatic CYP2C7 in adult male and female rats neonatally exposed to Phenobarbital: a developmental profile of gender dependent P450s. J. Pharmacol. Exp. Ther. 293 (2000) 1027-1033
3. Ahlbom J., Fredriksson A., and Eriksson P. Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res. 645 (1994) 318-324
4. Anadon A., Martinez-Larranaga M.R., Fernandiz-Cruz M.L., Diaz M.J., Fernandiz M.C., and Martinez M.A. Toxicokinetics of deltamethrin and 4'-HO-metabolite in the rat. Toxicol. Appl. Pharmacol. 141 (1996) 8-16
5. Anand S.S., Kim K.-B., Padilla S., Muralidhara S., Kim H.J., Fisher J.W., and Bruckner J.V. Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. Drug Metab. Dispos. 34 (2006) 389-397
6. ATSDR. Toxicological Profile for Pyrethrins and Pyrethroids (2001), Agency for Toxic Substances and Disease Registry, Atlanta, GA
7. Aziz M.H., Agrawal A.K., Adhami V.M., Shukla Y., and Seth P.K. Neurodevelopmental consequences of gestational exposure (GD14-GD20) to low dose deltamethrin in rats. Neurosci. Lett. 300 (2001) 161-165
8. Aziz M.H., Agrawal A.K., and Seth P.K. Deltamethrin-induced neurotoxicity in rats exposed during gestation period: neurochemical and neurobehavioral studies. Ann. Neurosci. 8 (2001) 113-118
9. Casida J.E., and Quistad G.B. Golden age of insecticide research: past, present, or future?. Annu. Rev. Entomol. 43 (1998) 1-16
10. Castonguay A., Pepin P., and Briere N. Modulation of 4-(methyl nitrosamino)-1-butanone demethylation and denitrosation by rat liver microsomes. Cancer Lett. 59 (1991) 67-74
11. Chen H., Xiao J., Hu G., Zhou J., Xiao H., and Wang X. Estrogenicity of organophosphorus and pyrethroid insecticides. J. Toxicol. Environ. Health A 65 (2002) 1419-1435
12. Cremer J.E., and Seville M.P. Comparative effects of two pyrethroids, deltamethrin and cismethrin on plasma catecholamines and on blood glucose and lactate. Toxicol. Appl. Pharmacol. 66 (1982) 124
13. Crofton K.M., and Reiter L.W. Pyrethroid insecticides and the gamma-aminobutyric acidA receptor complex: motor activity and the acoustic startle response in the rat. J. Pharmacol. Exp. Ther. 243 (1987) 946-954
14. Dayal M., Parmar D., Dhawan A., Dwivedi U.N., Doehmer J., and Seth P.K. Induction of rat brain and liver cytochrome P450 1A1/1A2 and 2B1/2B2 isoenzymes by deltamethrin. Environ. Pharmacol. Toxicol. 7 (1999) 169-178
15. Dayal M., Parmar D., Ali M., Dhawan A., Dwivedi U.N., and Seth P.K. Induction of rat brain cytochrome P450s by deltamethrin: regional specificity and correlation with neurobehavioral toxicity. Neurotox. Res. 3 (2001) 351-357
16. Dayal M., Parmar D., Dhawan A., Ali M., Dwivedi U.N., and Seth P.K. Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin. Food Chem. Toxicol. 41 (2003) 431-437
17. de Boer S.F., van der Gugten J., Slangen J.L., and Hijzen T.H. Changes in plasma corticosterone and catecholamine contents induced by low doses of deltamethrin in rats. Toxicol. 49 (1988) 263-270
18. Eriksson P. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicol. 18 (1997) 719-726
19. Eriksson P., and Nordberg A. Effects of two pyrethroids, bioallethrin and deltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Toxicol. Appl. Pharmacol. 102 (1990) 456-463
20. Eriksson P., Johansson U., Ahlbom J., and Fredriksson A. Neonatal exposure to DDT induces increased susceptibility to pyrethroid (bioallethrin) exposure at adult age-changes in cholinergic muscarinic receptor and behavioural variables. Toxicol. 77 (1993) 21-30
21. Ginsberg G., Slikker J.W., Bruckner J., and Sonawane B. Incorporating children's toxicokinetics into a risk framework. Environ. Health Perspect. 112 (2004) 272-283
22. Go V., Garey J., Wolff M.S., and Pogo B.G. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Environ. Health Perspect. 107 (1999) 173-177
23. Gupta A., Agarwal R., and Shukla G.S. Functional impairment of blood-brain barrier following pesticide exposure during early development in rats. Hum. Exp. Toxicol. 18 (1999) 174-179
24. Gupta A., Nigam D., Gupta A., Shukla G.S., and Agarwal A.K. Effect of pyrethroid-based liquid mosquito repellent inhalation on the blood-brain barrier function and oxidative damage in selected organs of developing rats. J. Appl. Toxicol. 19 (1999) 67-72
25. Hodgson A.V., White T.B., White J.W., and Strobel H.W. Expression analysis of the mixed connection oxidase system in rat brain by the polymerase chain reaction. Mol. Cell. Biochem. 120 (1993) 171-179
26. Husain R., Malaviya M., Seth P.K., and Hussain R. Differential responses of regional brain polyamines following in utero exposure to synthetic pyrethroid insecticide: a preliminary report. Bull. Environ. Contam. Toxicol. 49 (1992) 402-409
27. Kaneko H., Izumi T., Ueda Y., Matsuo M., and Miyamoto J. Metabolism and placental transfer of stereoisomers of tetramethrin isomers in pregnant rats. J. Pestic. Sci. 9 (1984) 249-258
28. Kim I.Y., Shin J.H., Kim H.S., Lee S.J., Kang I.H., Kim T.S., Moon H.J., Choi K.S., Moon A., and Han S.Y. Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J. Reprod. Dev. 50 (2004) 245-255
29. Lawrence L.J., and Casida J.E. Stereospecific action of pyrethroid insecticides on the gamma-aminobutyric acid-ionophore complex. Science 221 (1983) 1399-1401
30. Lazarini C.A., Florio J.C., Lemonica I.P., and Bernardi M.M. Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity and striatal dopamine levels in male and female rats. Neurotoxicol. Teratol. 23 (2001) 665-673
31. Lowry O.H., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin-Phenol reagent. J. Biol. Chem. 193 (1951) 265-275
32. Malaviya M., Husain R., Seth P.K., and Husain R. Perinatal effects of two pyrethroid insecticides on brain neurotransmitter function in the neonatal rat. Vet. Hum. Toxicol. 35 (1993) 119-122
33. McEwen B.S. Neural gonadal steroid action. Science 211 (1981) 1303-1311
34. Moniz A.C., Bernardi M.M., Souza-Spinosa H.S., and Palermo-Neto J. Effects of exposure to a pyrethroid insecticide during lactation on the behavior of infant and adult rats. Braz. J. Med. Biol. Res. 23 (1990) 45-48
35. Moniz A.C., Cruz-Casallas P.E., Salzgeber S.A., Varoli F.M., Spinosa H.S., and Bernardi M.M. Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats. Neurotoxicol. Teratol. 27 (2005) 609-614
36. Narahashi T. Nerve membrane ion channels as the target site of insecticides. Mini Rev. Med. Chem. 2 (2002) 419-432
37. Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55 (1953) 416-421
38. Nissbrandt H., Bergquist F., Jonason J., and Engberg G. Inhibition of cytochrome P4502E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?. Synapse 40 (2001) 294-301
39. Omiecinski C.J., Hassett C., and Costa P. Developmental expression and in situ localisation of the phenobarbital inducible rat hepatic mRNAs for the cytochromes CYP 2B1, 2B2, 2C6 and CYP 3A1. Mol. Pharmacol. 38 (1990) 462-470
40. Omiecinski C.J., Redlich C.A., and Costa P. Induction and developmental expression of cytochrome P4501A1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. Cancer Res. 50 (1990) 4315-4321
41. Parmar D., Dhawan A., Dayal M., and Seth P.K. Immunochemical and biochemical evidence for expression of phenobarbital and 3-methylcholanthrene-inducible isozymes of cytochrome P450 in rat brain. Int. J. Toxicol. 17 (1998) 619-630
42. Pohl R.J., and Fouts J.R. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal. Biochem. 107 (1980) 150-155
43. Ray D.E., and Fry J.R. A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol. Ther. (Nov 28, 2005) (Electronic publication ahead of print)
44. Rickard J., and Brodie M.E. Correlation of blood and brain levels of the neurotoxic pyrethroid deltamethrin with the onset of symptoms in rats. Pestic. Biochem. Physiol. 23 (1985) 143-156
45. Roberge C., Beaudet M.J., and Anderson A. GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A. Biochem. Pharmacol. 68 (2004) 1383-1389
46. Rosenbrock H., Hagemeyer C.E., Singec I., Knoth R., and Volk B. Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms. J. Neuroendocrinol. 11 (1999) 597-604
47. Rutten A.A., Falke H.E., Catsburg J.F., Wortelboer H.M., Blaauboer B.J., Doorn L., van Leeuwen F.X., Theelen R., and Rietjens I.M. Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions. Arch. Toxicol. 66 (1992) 237-244
48. Schilter B., and Omiecinski C.J. Regional distribution and expression modulation of cytochrome P450 and epoxide hydrolase mRNAs in the rat brain. Mol. Pharmacol. 44 (1993) 990-996
49. Shafer T.J., Meyer D.A., and Crofton K.M. Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ. Health Perspect. 113 2 (2005) 123-136
50. Sheets L.P., Doherty J.D., Law M.W., Reiter L.W., and Crofton K.M. Age dependent differences in the susceptibility of rats to deltamethrin. Toxicol. Appl. Pharmacol. 126 (1994) 186-190
51. Shiba K., Kaneko H., Kakuta N., Yoshitake A., and Miyamoto J. Placental transfer of esfenvalerate and fenvalerate in pregnant rats. J. Pestic. Sci. 15 (1990) 169-174
52. Soh Y., Rhee H.M., Dong H.S., and Song B.J. Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting. Biochem. Biophys. Res. Commun. 227 (1996) 541-546
53. Talts U., Fredriksson A., and Eriksson P. Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin. Neurobio. Aging 19 (1998) 545-552
54. Towbin H.T., Staehlin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4350-4354
55. Vaglini F., Pardini C., Viaggi C., Bartoli C., Dinucci D., and Corsini G.U. Involvement of cytochrome P4502E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. J. Neurochem. 91 (2004) 285-298
56. WHO. WHO Recommended Insecticides for Indoor Residual Spraying Against Malaria Vectors (2001), World Health Organisation, Geneva
57. Xu M., Nelson G.B., Moore J.E., McCoy T.P., Dai J., Manderville R.A., Ross J.A., and Miller M.S. Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene. Toxicol. Appl. Pharmacol. 209 (2005) 28-38