Regulation of cell growth mediated by the calcitonin receptor

Cellular and Molecular Biology

Volumn 52, Issue 3, 2006, Pages 3-8

  Findlay, D M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Calcitonin receptor mediated cell growth

Indexed keywords

AMINO ACID; CALCITONIN RECEPTOR; PEPTIDE HORMONE;

CALCIUM HOMEOSTASIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; LACTATION; MITOGENESIS; MORPHOGENESIS; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; PHYSIOLOGY; PREGNANCY; REGULATORY MECHANISM; REVIEW; SKELETON;

CALCITONIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; MODELS, BIOLOGICAL; ORGANOGENESIS; RECEPTORS, CALCITONIN;

EID: 33746584067     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Asrari, M. and Lobner, D., Calcitonin potentiates oxygen-glucose deprivation-induced neuronal death. Exp. Neurol. 2001, 167: 183-188.
2. Chambers, T.J. and Magnus, C.J., Calcitonin alters behaviour of isolated osteoclasts. J. Pathol. 1982, 136: 27-39.
3. Chien, J., Ren, Y., Qing Wang, Y., Bordelon, W., Thompson, E., Davis, R., Rayford, W. and Shah, G., Calcitonin is a prostate epithelium-derived growth stimulatory peptide. Mol. Cell. Endocrinol. 2001, 181: 69-79.
4. Cornish J., Callon K.E., Bava U., Kamona S.A., Cooper G.J., Reid I.R. Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. Bone. 2001, 29: 162168.
5. Dacquin, R., Davey, R.A., Laplace, C., Levasseur, R., Morris, H.A., Goldring, S.R., Gebre-Medhin, S., Galson, D.L., Zajac, J.D. and Karsenty, G., Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J. Cell. Biol. 2004, 164: 509-514.
6. Delgado, M., Garrido, E., Martinez, C., Leceta, J. and Gomariz, R.P., Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptides (PACAP27) and PACAP38) protect CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis. Blood 1996, 87: 51525161.
7. Ding, Y.Q., Zhu, L.J., Bagchi, M.K. and Bagchi, I.C., Progesterone stimulates calcitonin gene expression in the uterus during implantation. Endocrinology. 1994, 135: 2265-2274.
8. Divieti, P., Inomata, N., Chapin, K., Singh, R., Juppner, H. and Bringhurst, F.R., Receptors for the carboxyl-terminal region of PTH(1-84) are highly expressed in osteocytic cells. Endocrinology. 2001, 142: 916-925.
9. waf1/cip1 and G2/M arrest. Mol. Endocrinol. 1999, 13: 1738-1750.
10. Findlay, D.M., deLuise, M., Michelangeli, V.P., Ellison, M. and Martin, T.J., Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line. Cancer Res. 1980, 40: 1311-1317.
11. Findlay, D.M., Michelangeli, V.P., Eisman, J.A., Frampton, R.J., Moseley, J.M., MacIntyre, I., Whitehead, R. and Martin, T.J., Calcitonin and 1,25-dihydroxyvitamin D3 receptors in human breast cancer cell lines. Cancer Res. 1980, 40: 4764-4767.
12. Findlay, D.M., Raggatt, L-J., Bouralexis, S., Hay S., Atkins, G.J. and Evdokiou, A., Calcitonin decreases the adherence and survival of HEK-293 cells by a caspase-independent mechanism. J. Endocrinol. 2002, 175: 715-725.
13. Findlay, D.M. and Sexton, P.M. Calcitonin. Growth Factors 2004, 22: 217-24.
14. Frisch, S.M. and Screaton, R.A., Anoikis mechanisms. Current Opinion Cell Biol. 2001, 13: 555-562.
15. Fujikawa, Y., Quinn, J.M., Sabokbar, A., McGee, J.O. and Athanasou, N.A., The human osteoclast precursor circulates in the monocyte fraction. Endocrinology. 1996, 137: 4058-4060.
16. Gillespie, M.T., Thomas, R.J., Pu, Z.Y., Zhou, H., Martin, T.J., and Findlay, D.M., Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers. Int. J. Cancer. 1997, 73: 812-815.
17. Hoff, A.O., Catala-Lehnen, P., Thomas, P.M., Priemel, M., Rueger, J.M., Nasonkin, I., Bradley, A., Hughes, M.R., Ordonez, N., Cote, G.J., Amling, M., Gagel, R.F., Increased bone mass is an unexpected phenotype associated with deletion of the CT gene. J. Clin. Invest. 2002, 110: 1849-1857.
18. Ikegame, M., Rakopoulos, M., Martin, T.J., Moseley, J.M., and Findlay D.M., Effects of continuous calcitonin treatment on osteoclast-like cell development and calcitonin receptor in mouse bone marrow cultures. J. Bone Miner. Res. 1996, 11: 456-465.
19. Irmak, M.K. and Kirici, Y., Time to reevaluate the therapeutic use of calcitonin and biological role attributable to parafollicular (C) cells. Med. Hypotheses. 2004, 62: 425-430.
20. Ismail, P.M., DeMayo, F.J., Amato, P. and Lydon J.P., Progesterone induction of calcitonin expression in the murine mammary gland. J. Endocrinol. 2004, 180: 287-295.
21. Jagger, C., Chambers, T. and Pondel, M., Transgenic mice reveal novel sites of calcitonin receptor gene expression during development. Biochem. Biophys. Res. Commun. 2000, 274: 124-129.
22. Kolakowski, L.F., GCRDb: a G-protein-coupled receptor database. Receptors and Channels. 1994, 2: 1-7.
23. Kuestner, R.E., Elrod, R., Grant, F.J., Hagen, F.S., Kuijper, J.L., Matthews, S.L., Sheppard, P.O., Stroop, S.D., Thompson, D.L., Whitmore, T., Findlay, D.M., Houssami, S., Sexton, P.M., and Moore, E.E., Cloning and characterization of an abundant subtype of the human calcitonin receptor. Mol. Pharmacol. 1994, 46: 246-255.
24. Kumar, S., Zhu, L.J., Polihronis, M., Cameron, S.T., Baird, D.T., Schatz, F., Dua, A., Ying, Y.K., Bagchi, M.K. and Bagchi, I.C., Progesterone induces calcitonin gene expression in human endometrium within the putative window of implantation. J. Clin. Endocrinol. Metab. 1998, 83: 4443-4450.
25. Kumar, S., Brudney, A., Cheon, Y.P., Fazleabas, A.T., Bagchi, I.C., Progesterone induces calcitonin expression in the baboon endometrium within the window of uterine receptivity. Biol. Reprod. 2003, 68: 1318-1323.
26. Li, Q., Wang, J., Armant, D.R., Bagchi, M.K., Bagchi, I.C., Calcitonin down-regulates Ecadherin expression in rodent uterine epithelium during implantation. J. Biol. Chem. 2002, 277: 46447-46455.
27. MacDonald, B.R., Takahashi, N., McManus, L.M., Holahan, J., Mundy, G.R., Roodman, G.D., Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures. Endocrinology. 1987, 120: 2326-2333.
28. Martin, T.J., Moseley, J.M. and Sexton, P.M., (2001) Calcitonin. In: Endocrinology. (4Edition), DeGroot L.J. and J.L. Jameson, J.L. (eds.), W.B. Saunders Company. Philadelphia. 2001, pp. 999-1008.
29. Martin, T.J. and Sims, N.A., Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol. Med. 2005, 11: 76-81.
30. Marx, S.J., Aurbach, G.D., Gavin, J.R. 3and Buell, D.W., Calcitonin receptors on cultured human lymphocytes. J. Biol. Chem. 1974, 249: 6812-6816.
31. Millet, I., Phillips, R.J., Sherwin, R.S., Ghosh, S., Voll, R.E., Flavell, R.A., Vignery, A. and Rincon, M., 2000 Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. J. Biol. Chem. 2000, 275: 15114-15121.
32. Ng, K.W., Livesey, S.A., Larkins, R.G. and Martin, T.J., Calcitonin effects on growth and on selective activation of type II isoenzyme of cyclic adenosine 3′:5′-monophosphate-dependent protein kinase in T 47D human breast cancer cells. Cancer Res. 1983, 43: 794-800.
33. Okubo, Y., Bessho, K., Fujimura, K., Kusumoto, K., Ogawa, Y. and Iizuka, T., Effect of elcatonin on osteoinduction by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 2000, 269: 317-321.
34. Plotkin, L.I., Weinstein, R.S., Parfitt, A.M., Roberson, P.K., Manolagas, S.C. and Bellido, T., Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J. Clin. Invest. 1999, 104: 1363-1374.
35. Raggatt, L-J., Evdokiou, A. and Findlay, D.M., Sustained activation of Erk1/2 MAPK and cell growth suppression by the insert negative, but not the insert-positive isoform of the human calcitonin receptor. J. Endocrinol. 2000, 167: 93-105.
36. Ren, Y., Chien, J., Sun, Y.P., Shah, G.V., Calcitonin is expressed in gonadotropes of the anterior pituitary gland: its possible role in paracrine regulation of lactotrope function. J. Endocrinol. 2001, 171: 217-28.
37. Sakai, H., Kobayashi, Y., Sakai, E., Shibata, M. and Kato, Y., Cell adhesion is a prerequisite for osteoclast survival. Biochem. Biophys. Res. Commun. 2000, 270: 550-556.
38. Sakuta, H., Inaba, K. and Muramatsu, S., Calcitonin gene-related peptide enhances apoptosis of thymocytes. J. Neuroimmunol. 1996, 67: 103-109.
39. Salido, M., Vilches, J. and Lopez, A., Neuropeptides bombesin and calcitonin induce resistance to etoposide induced apoptosis in prostate cancer cell lines. Histolog. Histopath. 2000, 15: 729-738.
40. Segawa, N., Nakamura, M., Nakamura, Y., Mori, I., Katsuoka, Y. and Kakudo, K., Phosphorylation of mitogen-activated protein kinase is inhibited by calcitonin in DU145 prostate cancer cells. Cancer Res. 2001, 61: 6060-6063.
41. Selander, K.S., Harkonen, P.L., Valve, E., Monkonen, J., Hannuniemi, R. and Vaananen, H.K., Calcitonin promotes osteoclast survival in vitro. Mol. Cell. Endocrinol. 1996, 122: 119-129.
42. Sexton, P.M., Findlay, D.M., and Martin, T.J., Calcitonin. Curr. Med. Chem. 1999, 6: 1067-1093.
43. Shah, G.V., Rayford, W., Noble, M.J., Austenfeld, M., Weigel, J., Vamos, S. and Mebust, W.K., Calcitonin stimulates growth of human prostate cancer cells through receptor-mediated increase in cyclic adenosine 3′,5′- monophosphates and cytoplasmic Ca2+ transients. Endocrinology. 1994, 134: 596-602.
44. Shah, G.V., Chien, J., Sun, Y.P., Puri, S. and Ravindra, R., Calcitonin inhibits anterior pituitary cell proliferation in the adult female rats. Endocrinology. 1999, 140: 4281-4291.
45. Sherwood, N.M., Krueckl, S.L. and McRory, J.E., The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocrine Rev. 2000, 21: 619-670.
46. Sun, Y.P., Lee, T.J. and Shah, G.V., Calcitonin expression in rat anterior pituitary gland is regulated by ovarian steroid hormones. Endocrinology. 2002, 143: 4056-4064.
47. Takahashi, N., Mundy, G.R., Kuehl, T.J. and Roodman G.D., Osteoclast-like cell formation in fetal and newborn long-term baboon marrow cultures is more sensitive to 1,25-dihydroxy-vitamin D3 than adult long-term marrow cultures. J. Bone Miner. Res. 1987, 2: 311-317.
48. Takahashi, S., Intrapituitary regulatory system of proliferation of mammotrophs in the pituitary gland. Zoolog. Sci. 2004, 21: 601-611.
49. Turner, P.R., Mefford, S., Christakos, S. and Nissenson, R.A., Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Mol. Endocrinol. 2000, 14: 241-254.
50. Villalba, M., Bockaert, J. and Journot, L., Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J. Neuroscience. 1997, 17: 83-90.
51. Wada, S., Udagawa, N., Nagata, N., Martin, T.J. and Findlay, D.M., Calcitonin receptor down-regulation relates to calcitonin resistance in mature mouse osteoclasts. Endocrinology. 1996, 137: 1042-1048.
52. Wada, S., Udagawa, N., Nagata, N., Martin, T.J., and Findlay, D.M., Physiological levels of calcitonin regulate the mouse osteoclast calcitonin receptor by a protein kinase Alpha-mediated mechanism. Endocrinology. 1996, 137, 312-320.
53. Wallach, S., Rousseau, G., Martin, L. and Azria, M., Effects of calcitonin on animal and in vitro models of skeletal metabolism. Bone. 1999, 25: 509-516.
54. Wang, J., Rout, U.K., Bagchi, I.C. and Armant, D.R., Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin. Development. 1998, 125: 4293-4302.
55. Wang, Y.Q., Yuan, R., Sun, Y.P., Lee, T.J. and Shah, G.V., Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland: evidence for the involvement of transforming growth factor beta 1 in calcitonin action. Endocrinology. 2003, 144: 2164-2171.
56. Wang, X., Nakamura, M., Mori, I., Takeda, K., Nakamura, Y., Utsunomiya, H., Yoshimura, G., Sakurai, T. and Kakudo, K., Calcitonin receptor gene and breast cancer: quantitative analysis with laser capture microdissection. Breast Cancer Res. Treat. 2004, 83:109-117.
57. Wu, G., Burzon, D.T., di Sant'Agnese, P.A., Schoen, S., Deftos, L.J., Gershagen, S. and Cockett, A.T., Calcitonin receptor mRNA expression in the human prostate. Urology 1996, 47: 376-381.
58. Zhang, Z., Hernandez-Lagunas, L., Horne, W.C. and Baron, R., Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. J. Biol. Chem. 1999, 274: 25093-25098.
59. Zhang, Z., Baron, R. and Horne, W.C., 2000 Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation. J. Biol. Chem. 2000, 275: 37219-37223.
60. Zhu, L-J., Bagchi, M.K. and Bagchi, I.C., Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation. Endocrinology. 1998, 139: 330-339.
61. Zhu, L.J., Cullinan-Bove, K., Polihronis, M., Bagchi, M.K. and Bagchi, I.C., Calcitonin is a progesterone-regulated marker that forecasts the receptive state of endometrium during implantation. Endocrinology. 1998, 139: 3923-3934.