Bovine CD14 receptor produced in plants reduces severity of intramammary bacterial infection

FASEB Journal

Volumn 20, Issue 9, 2006, Pages 1345-1351

  Nemchinov, Lev G ^a   Paape, Max J ^a   Sohn, Eun J ^a   Bannerman, Douglas D ^a   Zarlenga, Dante S ^a   Hammond, Rosemarie W ^a,b  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Apoptosis; Coliform mastitis; LPS; Plant derived therapeutic; Potato virus X

Indexed keywords

CD14 ANTIGEN; HISTIDINE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PLANT EXTRACT; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CLINICAL FEATURE; CONTROLLED STUDY; COW; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; IMMUNE RESPONSE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MASTITIS; NONHUMAN; OUTER MEMBRANE; PLANT; PLANT VIRUS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEPTIC SHOCK; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BACTERIAL INFECTION; CATTLE; CATTLE DISEASE; CONSENSUS SEQUENCE; FEMALE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; MICROBIOLOGY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; POTEXVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOBACCO; TRANSGENIC PLANT; UDDER; VASCULAR ENDOTHELIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); BOS TAURUS; ESCHERICHIA COLI; NEGIBACTERIA; NICOTIANA BENTHAMIANA; POTATO VIRUS X;

ANIMALS; ANTIGENS, CD14; APOPTOSIS; BACTERIAL INFECTIONS; BASE SEQUENCE; CATTLE; CATTLE DISEASES; CLONING, MOLECULAR; CONSENSUS SEQUENCE; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INTERLEUKIN-8; MAMMARY GLANDS, ANIMAL; PLANTS, GENETICALLY MODIFIED; POLYMERASE CHAIN REACTION; POTEXVIRUS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOBACCO; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33746552407     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5295com     Document Type: Article

References (25)

1. Banks, K. L., and Michaels, F. H. (1985) Stimulation and killing of bovine mononuclear leukocytes by bacterial lipopolysaccharide (endotoxin). Am. J. Vet. Res. 46, 1568-1572
2. Loppnow, H., Stelter, F., Schonbeck, U., Schluter, C., Ernst, M., Schutt, C., and Flad, H. D. (1995) Endotoxin activates human vascular smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14. Infect. Immun. 63, 1020-1026
3. Pugin, J., Ulevitch, R. J., and Tobias, P. S. (1995) Activation of endothelial cells by endotoxin: Direct versus indirect pathways and the role of CD14. Prog. Clin. Biol. Res. 392, 369-373
4. Qureshi, S.T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., and Malo, D. (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr-4). J. Exp. Med. 189, 615-624
5. National Mastitis Council. (1996) Current Concepts of Bovine Mastitis, 4th Ed, National Mastitis Council, Madison, Wisconsin
6. Lee, J.W., Paape, M. J., and Zhao, X. (2003) Recombinant bovine soluble CD14 reduces severity of experimental Escherichia coli mastitis in mice. Vet. Res. 34, 307-316
7. Lee, J.W., Paape, M. J., Elsasser, T. H., and Zhao, X. (2003) Recombinant soluble CD14 reduces severity of intramammary infection by Escherichia coli. Infect. Immun. 71, 4034-4039
8. Wang, Y., Paape, M. J., and Worku, M. (1997) Detection and identification of soluble CD14 in bovine milk. J. Cell Biol. Mol. Biol. Cell 8 (Suppl.), A85
9. Paape, M. J., Lilius, E. M., Wiitanen, P. A., Kontio, M. P., and Miller, R. H. (1996) Intramammary defense against infections induced by Escherichia coli in cows. Am. J. Vet. Res. 57, 477-482
10. Ma, J, K-C. (2000) Genes, greens, and vaccines. Nature Biotechnol. 18, 1141-1142
11. Wang, Y., Zarlenga, D. S., Paape, M. J., and Dahl, G. E. (2002) Recombinant bovine soluble CD14 sensitizes the mammary gland to lipopolysaccharide. Vet. Immunol. Immunopathol. 86, 115-124
12. Lutcke H.A., Chow, K. C., Mickel, F. S., Moss, K. A., Kern, H. F., and Scheele, G. A. (1987) Selection of AUG initiation codons differs in plants and animals. EMBO J. 6, 43-48
13. Chapman, S., Kavanagh, T., and Baulcombe, D. C. (1992) Potato virus X as a vector for gene expression in plants. Plant J. 2, 549-557
14. Sohn, E. J., Paape, M. J., Peters, R. R., Fetterer, R. H., Talbot, N. C., and Bannerman, D. D. (2004) The production and characterization of anti-bovine CD14 monoclonal antibodies. Vet. Res. 35, 597-608
15. Bannerman, D.D., Paape, M. J., Hare, W. R., and Sohn, E. J. (2003) Increased levels of LPS binding protein in bovine blood and milk following bacterial lipopolysaccharide challenge. J. Dairy Sci. 86, 3128-3137
16. Shuster, D. E., Lee, E. K., and Kehrli, M. E., Jr. (1996) Bovine growth, inflammatory cytokine production, and neutrophil recruitment during coliform mastitis in cows within ten days after calving, compared with cows at midlactation. Am. J. Vet. Res. 57, 1569-1575
17. Bannerman, D.D., Sathyamoorthy, M., and Goldblum, S. E. (1998) Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junctions proteins. J. Biol. Chem. 273, 35371-35380
18. Miller, R. H., Paape, M. J., and Acton, J. C. (1986) Comparison of milk somatic cell counts by Coulter and Fossomatic counters. J. Dairy Sci. 69, 1942-1946
19. Bannerman, D. D., Paape, M. J., Lee, J. W., Zhao, X., Hope, J. C., and Rainard, P. (2004) Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin. Diagn. Lab. Immunol. 11, 463-472
20. Bramley, A. J. (1976) Variation in the susceptibility of lactating and non-lactating bovine udders to infection when infused with Escherichia coli. J. Dairy Sci. 79, 3094-3103
21. Bannerman, D. D., and Goldblum, S. E. (2003) Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis. Am. J. Physiol. 284, L899-L914
22. Bannerman, D. D., Tupper, J. C., Erwert, R. D., Winn, R. K., and Harlan, J. M. (2002) Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1. J. Biol. Chem. 277, 8048-8053
23. Ma, J.K-C., Drake, P. M. W., and Christou, P. (2003) The production of recombinant pharmaceutical proteins in plants. Nature Rev. Genet. 4, 794-805
24. Streatfield, S. J., and Howard, J. A. (2003) Plant-based vaccines. Int. J. Parasitol. 33, 479-493
25. Wall, R. J., Powell, A. M., Paape, M. J., Kerr, D. E., Bannerman, D. D., Pursel, V. G., Wells, K. D., Talbot, N., and Hawk, H. W. (2005) Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nature Biotechnol. 23, 445-451