Genetic approaches to the improvement of fertility traits in the pig

Veterinary Journal

Volumn 172, Issue 2, 2006, Pages 234-247

  Spotter A ^a   Distl, O ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Litter size; Marker assisted selection; Pig; Quantitative trait locus

Indexed keywords

PROTEOME;

BLASTOCYST; EMBRYO DEVELOPMENT; FERTILITY; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOMICS; GENOTYPE; GESTATION PERIOD; MOLECULAR GENETICS; NIDATION; NONHUMAN; PHENOTYPE; PIG FARMING; PROTEOMICS; QUANTITATIVE TRAIT LOCUS; REPRODUCTION; REVIEW; SWINE;

ANIMALS; ANIMALS, NEWBORN; BREEDING; FEMALE; FERTILITY; LITTER SIZE; MALE; PREGNANCY; QUANTITATIVE TRAIT LOCI; SELECTION (GENETICS); SWINE;

ANIMALIA; MAMMALIA; SUIDAE; SUS SCROFA;

EID: 33746520681     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2005.11.013     Document Type: Review

References (163)

1. Anderson L. Growth, protein content and distribution of early pig embryos. The Anatomical Record 190 (1978) 143-154
2. Anegon I., Cuturi M.C., Godard A., Moreau M., Terqui M., Martinat-Botte F., and Soulillou J.P. Presence of leukaemia inhibitory factor and interleukin 6 in porcine uterine secretions prior to conceptus attachment. Cytokine 6 (1994) 493-499
3. Archibald A.L., Haley C.S., Brown J.F., Couperwhite S., McQueen H.A., Nicholson D., Coppieters W., Van de Weghe A., Stratil A., Wintero A.K., et al. The PiGMaP consortium linkage map of the pig (Sus scrofa). Mammalian Genome 6 (1995) 157-175
4. Ashworth C.J. Advances in embryo mortality research. Proceedings of the International Pig Veterinary Society 1 (1998) 231-237
5. Bidanel, J.P., 1997. Genetic aspects of prolificacy in Meishan pigs. What have we learned from the Meishan pig? Institute of Animal Science, Seminar (polycopy), Wageningen, May 5, 1997, pp. 1-6.
6. Biensen N.J., Wilson M.E., and Ford S.P. The impact of either a Meishan or Yorkshire uterus on Meishan or Yorkshire fetal and placental development to days 70, 90, and 110 of gestation. Journal of Animal Science 76 (1998) 2169-2176
7. Biensen N.J., Wilson M.E., and Ford S.P. The impacts of uterine environment and fetal genotype on conceptus size and placental vascularity during late gestation in pigs. Journal of Animal Science 77 (1999) 954-959
8. Bolet G., Martinat-Botte F., Locatelli P., Gruand J., Terqui M., and Berthelot F. Components of prolificacy of hyperprolific Large-White sows compared with Meishan and control Large-White sows. Genetics, Selection, Evolution 18 (1986) 333-342
9. Bösch M., Röhe R., Looft H., and Kalm E. Die Selektion auf Wurfgröße beim Schwein. Archiv für Tierzucht 42 (1999) 555-570
10. Braunschweig M.H., Paszek A.A., Weller J.I., Da Y., Hawken R.J., Wheeler M.B., Schook L.B., and Alexander L.J. Generation and exploration of a dense genetic map in a region of a QTL affecting corpora lutea in a Meishan × Yorkshire cross. Mammalian Genome 12 (2001) 719-723
11. Brigstock D.R., Kim G.Y., and Steffin C.L. Pig uterine fluid contains the developmentally-regulated neurotrophic factor, pleiotrophin. The Journal of Endocrinology 148 (1996) 103-111
12. Brigstock D.R., Kim G.Y., Steffin C.L., Liu A., Vegunta R.K., and Ismail N.H. High molecular mass forms of epidermal growth factor in pig uterine secretions. Journal of Reproduction and Fertility 108 (1996) 313-320
13. Brigstock D.R., Heap R.B., Baker P.J., and Brown K.D. Purification and characterization of heparin-binding growth factors from porcine uterus. The Biochemical Journal 266 (1990) 273-282
14. Brisbane J.R., and Gibson J.P. Balancing selection response and rate of inbreeding by including genetic relationships in selection decisions. Theoretical and Applied Genetics 91 (1995) 421-431
15. Caetano, A.R., Johnson, R.K., Pomp, D., 2002. RNA expression profiling of ovarian follicle development in swine lines selected for increased ovulation rate. In: Proceedings of the Seventh World Congress on Genetics Applied to Livestock Production, Montpellier, vol. 30, pp. 657-660.
16. Campbell E.M.G., Nonnemann D., and Rohrer G.A. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. Journal of Animal Science 81 (2003) 1706-1714
17. Cassady J.P., Johnson R.K., Pomp D., Rohrer G.A., van Vleck L.D., Spiegel E.K., and Gilson K.M. Identification of quantitative trait loci affecting reproduction in pigs. Journal of Animal Science 79 (2001) 623-633
18. Chang H.S., Cheng W.T., Wu K.H., and Choo K.B. Identification of genes expressed in the epithelium of porcine oviduct containing early embryos at various stages of development. Molecular Reproduction and Development 56 (2000) 331-335
19. Chen K.F., Huang L.S., Li N., Zhang Q., Luo M., and Wu C.X. The genetic effect of estrogen receptor (ESR) on litter size traits in pig. Yi Chuan Xue Bao 27 (2000) 853-857
20. Collins F.S. Positional cloning moves from perditional to traditional. Nature Genetics 9 (1995) 347-350
21. Copeland N.G., Jenkins N.A., Gilbert D.J., Eppig J.T., Maltais L.J., Miller J.C., Dietrich W.F., Weaver A., Lincoln S.E., Stehen R.G., et al. A genetic linkage map of the mouse: current applications and future prospects. Science 235 (1993) 1046-1049
22. Craig A.M., and Denhardt D.T. The murine gene encoding secreted phosphoprotein 1 (OPN, osteopontin): Promoter structure, activity, and induction in vivo by estrogen and progesterone. Gene 100 (1991) 163-171
23. Dantzer V. Electron microscopy of the initial stages of placentation in the pig. Anatomy and Embryology 172 (1985) 281-293
24. Daza A., Evangelista J.N.B., and Gutierrez-Barquin M.G. The effect of maternal and litter factors on piglet mortality rate. Annales de Zootechnie 48 (1999) 317-325
25. Dekkers J.M., and Hospital F. The use of molecular genetics in the improvement of agricultural populations. Nature Reviews Genetics 3 (2002) 22-32
26. De Koning D.J., Rattink A.P., Harlizius B., Groenen M.A.M., Brascamp E.W., and van Arendonk J.A.M. Detection and characterization of quantitative trait loci for growth and reproduction traits in pigs. Livestock Production Science 72 (2001) 185-198
27. De Vries A.G. A model to estimate economic value of traits in pig breeding. Livestock Production Science 21 (1989) 49-66
28. Diatchenko L., Lau Y.F., Campbell A.P., Chenchik A., Moqadam F., Huang B., Lukyanov S., Lukyanov K., Gurskaya N., Sverdlov E.D., and Siebert P.D. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 6025-6030
29. Diehl J.R., Henricks D.M., and Gray S.L. EGF and IGF-1 in the uterine and oviductal fluids of pregnant and nonpregnant pigs from day 10 to day 18. Biology of Reproduction 50 Suppl. 1 (1994) 122
30. Drögemüller C., Hamann H., and Distl O. Candidate gene markers for litter size in different German pig lines. Journal of Animal Science 79 (2001) 2565-2570
31. Dziuk P.J. Effect of number of embryos and uterine space on embryo survival in the pig. Journal of Animal Science 27 (1968) 673-676
32. Dziuk P.J. Effect of migration, distribution and spacing of pig embryos on pregnancy and fetal survival. Journal of Reproduction and Fertility Suppl. 33 (1985) 57-63
33. Elangovan S., and Moulton B.C. Blastocyst implantation in the rat and the immunohistochemical distribution and rate of synthesis of uterine lysosomal cathepsin D. Biology of Reproduction 23 (1980) 663-668
34. Ellegren H., Chowdhary B.P., Fredholm M., Hoyheim B., Johansson M., Brauner Nielsen P.B., Thomsen P.D., and Andersson L. A physically anchored linkage map of pig chromosome 1 uncovers sex- and position-specific recombination rates. Genomics 24 (1994) 342-350
35. Ellegren H., Chowdhary B.P., Johansson M., Marklund L., Fredholm M., Gustavsson I., and Andersson L. A primary linkage map of the porcine genome reveals a low rate of genetic recombination. Genetics 137 (1994) 1089-1100
36. Fahrenkrug S.C., Campbell E.M., Vallet J.L., and Rohrer G.A. Physical assignment of the porcine erythropoietin receptor gene to SSC2. Animal Genetics 31 (2000) 69-70
37. Fireman F.A.T., and Siewerdt F. Efeito do peso ao nascer sobre a mortalidade de leitoes do nascimento ate 21 dias de idade. Revista Brasileira de Zootecnia 26 (1997) 479-484
38. Ford S.P. Embryonic and fetal development in different genotypes in pigs. Journal of Reproduction and Fertility Suppl. 52 (1997) 165-176
39. Garlow J.E., Ka H., Johnson G.A., Burghardt R.C., Jaeger L.A., and Bazer F.W. Analysis of osteopontin at the maternal-placental interface in pigs. Biology of Reproduction 66 (2002) 718-725
40. Gearing D.P., Thut C.J., Vandenbos T., Gimpel S.D., Delaney P.B., King J., Price V., Cosman D., and Beckmann M.P. Leukaemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp 130. The EMBO Journal 10 (1991) 2839-2848
41. Geisert R.D., and Yelich J.V. Regulation of conceptus development and attachment in pigs. Journal of Reproduction and Fertility Suppl. 52 (1997) 133-149
42. Geisert R.D., Blair R.M., Pratt T., and Zavy M.T. Characterization and proteolytic activity of a cathepsin L-like polypeptide in endometrium and uterine flushings of cycling, pregnant and steroid-treated ovariectomized gilts. Reproduction, Fertility, and Development 9 (1997) 395-402
43. Geisert R.D., Yelich J.V., Pratt T., and Pomp D. Expression of an inter-α-trypsin inhibitor heavy chain-like protein in the pig endometrium during the oestrous cycle and early pregnancy. Journal of Reproduction and Fertility 114 (1998) 35-43
44. 2 population. Animal Genetics 33 (2002) 448-450
45. Gimelfarb A., and Lande R. Simulation of marker assisted selection in hybrid populations. Genetical Research 63 (1994) 39-47
46. Giudice L.C. Genes associated with embryonic attachment and implantation and the role of progesterone. Journal of Reproductive Medicine 44 (1999) 165-171
47. Gladney C.D., Martinez V.G., Brumbaugh K.A., DeGroot B.J., Linville R.C., Oommen A.M., Huebinger R.M., Messer L., Allan M.F., and Pomp D. Mapping of the Prostaglandin-Endoperoxide Synthase 2 (PTGS2) gene to Porcine chromosome 9 and Bovine chromosome 16 by linkage analysis using novel PCR-RFLP. Journal of Animal Science 77 (1999) 787-788
48. Goliasova E., and Wolf J. Impact of the ESR gene on litter size and production traits in Czech Large White pigs. Animal Genetics 35 (2004) 293-297
49. Gonzalez-Ramon N., Alava M.A., Sarsa J.A., Pineiro M., Escartin A., Garcia-Gil A., Lampreave F., and Pineiro A. The major acute phase serum protein in pigs is homologous to human plasma kallikrein sensitive PK-120. FEBS Letters 371 (1995) 227-230
50. Grandinson, K., Rydhmer, L., Strandberg, E., Lund, M.S., 2000. Estimation of genetic parameters for mortality and causes of death in piglets. In: 51st Annual Meeting of the European Association of Animal Production, The Hague, 21-24 August 2000.
51. 1-acetyltransferase from the periimplantation porcine uterus by messenger ribonucleic acid differential display, temporal and conceptus-modulated gene expression. Endocrinology 137 (1996) 5447-5455
52. Groenen M.A.M., de Vries B.J., and van der Poel J.J. Alignment of the PiGMaP and USDA linkage maps of porcine chromosomes 3 and 9. Animal Genetics 27 (1996) 355-357
53. Gross T.S., Mirando M.A., Young K.H., Beers S., Bazer F.W., and Thatcher W.W. Reorientation of prostaglandin F secretion by calcium ionophore, estradiol, and prolactin in perifused porcine endometrium. Endocrinology 127 (1990) 637-642
54. Hadley M.E. Endocrinology. fourth ed. (1996), Prentice Hall, Upper Saddle River, NJ
55. Haining R.E.B., Cameron I.T., van Papendorp C., Davenport A.P., Prentice A., Thomas E.J., and Smith S.K. Epidermal growth factor in human endometrium: proliferative effects in culture and immunocytochemical localization in normal and endometriotic tissues. Human Reproduction 6 (1991) 1200-1205
56. Haley C. Advances in quantitative trait locus mapping. In: Dekkers J.C.M., Lamont S.J., and Rothschild M.F. (Eds). From Jay Lush to Genomics: Visions for Animal Breeding and Genetics (1999), Iowa State University, Ames 47-59
57. Haley C.S., and Lee G.J. Genetic basis of prolificacy in Meishan pigs. Journal of Reproduction and Fertility Suppl. 48 (1993) 247-259
58. Haley C.S., Lee G.J., and Ritchie M. Comparative reproductive performance in Meishan and Large White pigs and their crosses. Animal Science 60 (1995) 259-267
59. Hamann, H., Drögemüller, C., Krieter, J., Presuhn, U., Wallenburg, J., Distl, O., 2000. Genetic markers for litter size in German pig breeds. In: 51st Annual Meeting of the European Association of Animal Production, The Hague, 21-24 August 2000.
60. Hamann H., Steinheuer R., and Distl O. Estimation of genetic parameters for litter size as a sow and boar trait in German herdbook Landrace and Pietrain swine. Livestock Production Science 85 (2004) 201-207
61. Hanenberg E.H., Knol E.F., and Merks J.W. Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livestock Production Science 69 (2001) 179-186
62. Harney J.P., Ott T.L., Geisert R.D., and Bazer F.W. Retinol-binding protein gene expression in cyclic and pregnant endometrium of pigs, sheep and cattle. Biology of Reproduction 49 (1993) 1066-1073
63. Herpin P., Le Dividich J., and Amaral N. Effect of selection for lean tissue growth on body composition and physiological state of the pig at birth. Journal of Animal Science 71 (1993) 2645-2653
64. Hilton D.J. LIF: Lots of interesting functions. Trends of Biochemical Science 17 (1992) 72-76
65. Isler B.J., Irvin K.M., Neal S.M., Moeller S.J., and Davis M.E. Examination of the relationship between the estrogen receptor gene and reproductive traits in swine. Journal of Animal Science 80 (2002) 2334-2339
66. Jiang, Z., Robinson, J.A.B., Verrinder Gibbins, A.M., Gibson, J.P., Archibald, A.L., Haley, C.S., 2002. Mapping of QTLs for prolificacy traits on SSC8 using a candidate gene approach. In: Proceedings of the Seventh World Congress on Genetics Applied to Livestock Production, Montpellier, vol. 30, pp. 633-636.
67. Kapke P., Wang L., Helm J.M., and Rothschild M.F. Integration of the PiGMaP and USDA maps for porcine chromosome 14. Animal Genetics 27 (1996) 187-190
68. Kennedy T.G., Brown K.D., and Vaughan T.J. Expression of the genes for the epidermal growth factor receptor and its ligands in porcine oviduct and endometrium. Biology of Reproduction 50 (1994) 751-756
69. Kim G.Y., Besner G.E., Steffen C.L., McCarthy D.W., Downing M.T., Luquette M.H., Abad M.S., and Brigstock D.R. Purification of heparin-binding EGF-like growth factor from pig uterine flushings and its production by endometrial tissues. Biology of Reproduction 52 (1995) 561-571
70. Kim J.G., Vallet J.L., and Christenson R.K. Characterization of uterine epidermal growth factor during early pregnancy in pigs. Domestic Animal Endocrinology 20 (2001) 253-265
71. King A.H., Jiang Z., Gibson J.P., Haley C.S., and Archibald A.L. Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biology of Reproduction 68 (2003) 2172-2179
72. Kirkpatrick, B.W., 2002. QTL and candidate gene effects on reproduction in livestock: Progress and prospects. In: Proceedings of the Seventh World Congress on Genetics Applied to Livestock Production, Montpellier, vol. 30, pp. 633-636.
73. Kirschke H., Kembhavi A.A., Bohely P., and Barrett A.J. Action of rat liver cathepsin L on collagen and other substrates. The Biochemical Journal 201 (1982) 367-372
74. Knol, E.F., 2001. Genetic Aspects of Piglet Survival. Ph.D. dissertation, Wageningen University, Wageningen, The Netherlands.
75. Knol E.F., Leenhouwers J.I., and van der Lende T. Genetic aspects of piglet survival. Livestock Production Science 78 (2002) 47-55
76. Lahbib-Mansais Y., Leroux S., Milan D., Yerle M., Robic A., Jiang Z., Andre C., and Gellin J. Comparative mapping between humans and pigs: Localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels. Mammalian Genome 11 (2000) 1098-1106
77. Lander E., and Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11 (1995) 241-247
78. Lee G.J., and Haley C.S. Comparative farrowing to weaning performance in Meishan and Large White pigs and their crosses. Animal Science 60 (1995) 269-280
79. Leenhouwers J.I., Knol E.F., and van der Lende T. Differences in late prenatal development as an explanation for genetic differences in piglet survival. Livestock Production Science 78 (2002) 57-62
80. Legault C., and Gruand J. Improvement of prolificacy of sows by the formation of a hyperprolific line and its use in artificial insemination. Les Journées de la Recherche Porcine en France 8 (1976) 201-206
81. Li W., Jaffe R.C., and Verhage H.G. Immunocytochemical localization and messenger ribonucleic acid levels of a progesterone-dependent endometrial secretory protein (cathepsin L) in the pregnant cat uterus. Biology of Reproduction 47 (1992) 21-28
82. Li, N., Zhoa, Y.F., Xiao, L., Zang, F.J., Chen, Y.Z., Dai, R.J., Zang, J.S., Shen, S.Q., Chen, Y.F., Wu, C.X., 1998. Candidate gene analysis for identification of genetic loci controlling litter size in swine. In: Proceedings of the Sixth World Congress on Genetics Applied to Livestock Production, Armidale, vol. 26, pp. 183-186.
83. Liang P., and Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257 (1992) 967-971
84. Lim H., Paria B.C., Das S.K., Dinchuk J.E., Langenbach R., Traskos J.M., and Dey S.K. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell 91 (1997) 197-208
85. Linville R.C., Pomp D., Johnson R.K., and Rothschild M.F. Candidate gene analysis for loci affecting litter size and ovulation rate in swine. Journal of Animal Science 79 (2001) 60-67
86. Lofgren, D.L., Harris, D.L., Stewart, T.S., Anderson, D.D., Schinckel, A.P., Einstein, M.E., 1994. Genetic progress of the US Yorkshire breed. In: Proceedings of the Fifth World Congress on Genetics Applied to Livestock Production, Guelph, vol. 17, pp. 425-428.
87. Lopez-Corrales N.L., Beattie C.W., and Rohrer G.A. Cytogenetic assignment of 53 microsatellites from the USDA-MARC porcine genetic map. Cytogenetics and Cell Genetics 84 (1999) 140-144
88. Mannaertz B., Uilenbrock J., Schot P., and de Leeuw R. Folliculogenesis in hypophysectomized rats after treatment with recombinant human follicle stimulating hormone. Biology of Reproduction 51 (1994) 72-81
89. Marklund L., Johansson Moller M., Hoyheim B., Davies W., Fredholm M., Juneja R.K., Mariani P., Coppieters W., Ellegren H., and Andersson L. A comprehensive linkage map of the pig based on a wild pig-Large White intercross. Animal Genetics 27 (1996) 255-269
90. Mason R.W., Johnson D.A., Barrett A.J., and Chapman H. Elastinolytic activity of human cathepsin L. The Biochemical Journal 233 (1982) 925-927
91. Mellink C., Lahbib-Mansais Y., Yerle M., and Gellin J. PCR amplification, cloning and localization of the genes for pig FSHB and LHB. Cytogenetics and Cell Genetics 70 (1995) 224
92. Mendez E.A., Messer L.A., Larsen N.J., Robic A., and Rothschild M.F. Epidermal growth factor maps to pig chromosome 8. Journal of Animal Science 77 (1999) 494-495
93. Mersmann H.J., Stone R.T., Yen J.T., and Lindvall R.N. Factors affecting growth and survival of neonatal genetically obese and lean swine: cross fostering experiments. Growth 48 (1984) 209-220
94. Messer L., Wang L., Yelich J., Pomp D., Geisert R., and Rothschild M.F. Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine Chromosome 14. Mammalian Genome 7 (1996) 396
95. Metcalf D. Leukemia inhibitory factor - a puzzling polyfunctional regulator. Growth Factors 7 (1992) 169-173
96. Milan D. Notion du gène candidat. INRA Productions Animales, numéro hors série "Génétique moléculaire: principes et application aux populations animales" (2000) 119-123
97. Modric T., Kowalski A.A., Green M.L., Simmen R.C.M., and Simmen F.A. Pregnancy-dependent expression of leukaemia inhibitory factor (LIF), LIF receptor-β and interleukin-6 (IL-6) messenger ribonucleic acids in the porcine female reproductive tract. Placenta 21 (2000) 345-353
98. Moritz K.M., Lim G.B., and Wintour E.M. Developmental regulation of erythropoietin and erythropoiesis. American Journal of Physiology 273 (1997) R1829-R1844
99. Munoz G., Ovilo C., Amills M., and Rodriguez C. Mapping of the porcine oestrogen receptor 2 gene and association study with litter size in Iberian pigs. Animal Genetics 35 (2004) 242-244
100. Noguera J.L., Varona L., Gomez-Raya L., Sanchez A., Babot D., Estany J., Mecer L.A., Rothschild M., and Perez-Enciso M. Estrogen receptor polymorphism in Landrace pigs and its association with litter size performance. Livestock Production Science 82 (2003) 53-59
101. Ollivier L., Messer L.A., Rothschild M.F., and Legault C. The use of selection experiments for detecting quantitative trait loci. Genetical Research 69 (1997) 227-232
102. Paria B.C., and Dey S.K. Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Proceedings of the National Academy of Sciences of the United States of America 87 (1990) 4756-4760
103. Parrott J.A., Whaley P.D., and Skinner M.K. Extrahepatic expression of fibrinogen by granulosa cells: potential role in ovulation. Endocrinology 133 (1993) 1645-1649
104. Pearson P.L., Smith T.P., Sonstegard T.S., Klemcke H.G., Christenson R.K., and Vallet J.L. Porcine erythropoietin receptor: molecular cloning and expression in embryonic and fetal liver. Domestic Animal Endocrinology 19 (2000) 25-38
105. Pomp D., Caetano A.R., Bertani G.R., Gladney C.D., and Johnson R.K. Applying functional genomics research to the study of pig reproduction. Reproduction Suppl. 58 (2001) 277-292
106. Pope W.F. Embryonic mortality in swine. In: Zavy M.T., and Geisert R.D. (Eds). Embryonic Mortality in Domestic Species (1994), CRC Press, Boca Raton, FL 53-77
107. Prigent S.A., and Lemoine N.R. The type I (EGF-related) family of growth factor receptors and their ligands. Progress in Growth Factor Research 4 (1992) 1-24
108. Quiniou N., Dagorn J., and Gaudre D. Variation of piglets' birth weight and consequences on subsequent performance. Livestock Production Science 78 (2002) 63-70
109. Rao D.C., and Province M.A. In: Rao D.C. (Ed). Genetic Dissection of Complex Traits. Advances in Genetics vol. 42 (2001), Academic Press, San Diego
110. Rathje T.A., Rohrer G.A., and Johnson R.K. Evidence for quantitative trait loci affecting ovulation rate in pigs. Journal of Animal Science 75 (1997) 1486-1494
111. Rettenberger G., Bruch J., Fries R., Archibald A.L., and Hameister H. Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig. Mammalian Genome 7 (1996) 275-279
112. Rohrer G.A., Alexander L.J., Keele J.W., Smith T.P., and Beattie C.W. A microsatellite linkage map of the porcine genome. Genetics 136 (1994) 231-245
113. Rohrer G.A., Alexander L.J., Hu Z., Smith T.P., Keele J.W., and Beattie C.W. A comprehensive map of the porcine genome. Genome Research 6 (1996) 371-391
114. Rohrer G.A., Ford J.J., Wise T.H., Vallet J.L., and Christenson R.K. Identification of quantitative trait loci affecting female reproductive traits in a multigeneration Meishan-White Composite swine population. Journal of Animal Science 77 (1999) 1385-1391
115. Ross J.W., Ashworth M.D., Hurst A.G., Malayer J.R., and Geisert R.D. Analysis and characterization of differential gene expression during rapid trophoblastic elongation in the pig using suppression subtractive hybridization. Reproductive Biology and Endocrinology 1 (2003) 23
116. Rothschild M.F., and Bidanel J.P. Biology and genetics of reproduction. In: Rothschild M.F., and Ruvinsky A. (Eds). The Genetics of the Pig (1998), CAB International, New York 313-343
117. Rothschild M.F., Jacobson C., Vaske D., Tuggle C.K., Wang L., Short T., Eckardt G., Sasaki S., Vincent A., McLaren D., Southwood O., van der Stehen A., Mileham A., and Plastow G.S. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 201-205
118. Rothschild M.F., Messer L., Day A., Wales R., Short T., Southwood O., and Plastow G. Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mammalian Genome 11 (2000) 75-77
119. Savatier P., Lapillonne H., van Grunsven L.A., Rudkin B.B., and Samarut J. Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 12 (1996) 309-322
120. Short, T.H., Wilson, E.R., McLaren, D.G., 1994. Relationships between growth and litter traits in pig dam lines. In: Proceedings of the Fifth World Congress on Genetics Applied to Livestock Production, Guelph, vol. 17, pp. 413-416.
121. Short T.H., Rothschild M.F., McLaren D.G., Southwood O.I., Devries A.G., van der Steen A., Tuggle C.K., Helm J., Vaske D.A., Mileham A.J., and Plastow G.S. Effect of the estrogen receptor locus on reproduction and production traits in four commercial pig lines. Journal of Animal Science 75 (1997) 3138-3142
122. Short T.H., Southwood O.I., Devries A.G., McLaren D.G., Evans G.J., Mileham A.J., and Plastow G.S. Evidence of a new genetic marker for litter size in pigs. Journal of Animal Science 75 Suppl. 1 (1997) 29
123. Siewerdt F., and Cardellino R.A. Genetic parameters of piglet mortality from birth to 21 days of age in the Landrace breed. Revista da Sociedade Brasileira de Zootecnia 25 (1996) 902-909
124. Soller M. Marker assisted selection - an overview. Animal Biotechnology 5 (1994) 193-207
125. Southwood, O.I., Short, T.H., Plastow, G.S., Rothschild, M.F., 1999. A genetic marker for litter size in Landrace based pig lines. In: 50th Annual Meeting of the European Association of Animal Production, Zürich, 22-26 August 1999.
126. Spötter A., Drögemuller C., Kuiper H., Brenig B., Leeb T., and Distl O. Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21 → q22 and SSC10q11 → q12. Cytogenetics and Cell Genetics 95 (2001) 92-96
127. Spötter A., Kuiper H., Drögemuller C., Brenig B., Leeb T., and Distl O. Assignment of the porcine epidermal growth factor (EGF) gene to SSC8q2.3 → q2.4 by fluorescence in situ hybridization and radiation hybrid mapping. Animal Genetics 33 (2001) 166-167
128. Spötter A., Drögemuller C., Kuiper H., Brenig B., Leeb T., and Distl O. Molecular characterization and chromosomal assignment of the porcine gene for leukemia inhibitory factor LIF. Cytogenetics and Cell Genetics 93 (2001) 87-90
129. Spötter A., Drögemüller C., Kuiper H., Brenig B., Leeb T., and Distl O. Mapping and microsatellite marker development for the porcine leukemia inhibitory factor receptor (LIFR) and epidermal growth factor receptor (EGFR) genes. Cytogenetic and Genome Research 98 (2003) 216-220
130. Spötter A., Drögemüller C., Hamann H., and Distl O. Evidence of a new LIF associated genetic marker for litter size in a synthetic pig line. Journal of Animal Science 83 (2005) 2264-2270
131. Steinheuer, R., 2001. Schätzung von Varianzkomponenten und Kandidatengeneffekten für die paternale und maternale Komponente von Fruchtbarkeitsmerkmalen beim Schwein. Dissertation, School of Veterinary Medicine Hannover, Hannover, Germany.
132. Steinheuer R., Drögemüller C., Hamann H., Götz K.U., and Distl O. Einfluss von Kandidatengeneffekten auf die Anzahl lebend geborener und aufgezogener Ferkel bei Besamungsebern der Deutschen Landrasse. Züchtungskunde 75 (2003) 204-213
133. Stewart C.L. Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo. Molecular Reproduction and Development 39 (1994) 233-238
134. Stewart C.L., Kaspar P., Brunet L.J., Bhatt H., Gadi I., Köntgen F., and Abbondanzo S.J. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359 (1992) 76-79
135. Tess M.W., Bennett G.L., and Dickerson G.E. Simulation of genetic changes in life cycle efficiency of pork production I. A bioeconomic model. Journal of Animal Science 56 (1983) 336-353
136. Tess M.W., Bennett G.L., and Dickerson G.E. Simulation of genetic changes in life cycle efficiency of pork production. II. Effects of components on efficiency. Journal of Animal Science 56 (1983) 354-368
137. Tomooka Y., DiAugustine R.P., and McLachlan J.A. Proliferation of mouse uterine epithelial cells in vitro. Endocrinology 118 (1986) 1011-1018
138. Vallet J.L., Freking B.A., Leymaster K.A., and Christenson R.K. Allelic variation in the erythropoietin receptor gene is associated with uterine capacity and litter size in swine. Animal Genetics 36 (2005) 97-103
139. Vallée, M., Beaudry, D., Roberge, C., Matte, J.J., Blouin, R., Palin, M.F., 2002. Identification by subtractive hybridization of the most promising genes related to embryo survival in early gestating sows. In: Proceedings of the Seventh World Congress on Genetics Applied to Livestock Production, Montpellier, vol. 30, pp. 661-664.
140. van der Lende T., Knol E.F., and Leenhouwers J.I. Prenatal development as a predisposing factor for perinatal losses in pigs. Reproduction Suppl. 58 (2001) 247-261
141. Van Rens B.T.T.M., de Groot P.N., and van der Lende T. The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts. Theriogenology 57 (2002) 1635-1649
142. Villanueva B., Woolliams J.A., and Simm G. Strategies for controlling rates of inbreeding in MOET nucleus schemes for beef cattle. Genetics Selection Evolution 26 (1994) 517-535
143. Vincent A., Wang L., Tuggle C.K., Robic A., and Rothschild M.F. Prolactin receptor maps to pig chromosome 16. Mammalian Genome 8 (1997) 793-794
144. Vincent, A.L., Short, T.H., Southwood, O.I., Plastow, G.S., Tuggle, C.K., Rothschild, M.F., 1998. The prolactin receptor gene is associated with increased litter size in pigs. In: Proceedings of the Sixth World Congress on Genetics Applied to Livestock Production, Armidale, vol. 26, pp. 403-409.
145. Visscher P.M., van der Beek S., and Haley C.S. Marker assisted selection. In: Clark A.J. (Ed). Animal Breeding: Technology for the 21st Century (1998), Harwood Academic Publishers, Amsterdam 119-136
146. Wang X.N., and Greenwald G.S. Hypophysectomy of the cyclic mouse. II. Effects of follicle stimulating hormone (FSH) and luteinizing hormone on folliculogenesis, FSH and human chorionic gonadotropin receptors and steroidogenesis. Biology of Reproduction 48 (1993) 595-605
147. Waterhouse P., Ranjit S., Xiaojia G., Peeyush K.L., and Denhardt D.T. Regulated temporal and spatial expression of the calcium-binding proteins calcyclin and OPN (osteopontin) in mouse tissues during pregnancy. Molecular Reproduction and Development 32 (1992) 315-323
148. Webb A.J. Objectives and strategies in pig improvement: An applied perspective. Journal of Dairy Science 81 (1998) 36-46
149. Weller J.I. Quantitative Trait Loci Analysis in Animals (2001), CABI Publishing, London
150. Wilkie P.J., Paszek A.A., Beattie C.W., Alexander L.J., Wheeler M.B., and Schook L.B. A genomic scan of porcine reproductive traits reveals possible quantitative trait loci (QTLs) for number of corpora lutea. Mammalian Genome 10 (1999) 573-578
151. Wilson M.E., Biensen N.J., Youngs C.R., and Ford S.P. Development of Meishan and Yorkshire littermate conceptuses in either a Meishan or Yorkshire uterine environment to day 90 of gestation and to term. Biology of Reproduction 58 (1998) 905-910
152. Wilson M.E., Biensen N.J., and Ford S.P. Novel insight into the control of litter size in pigs, using placental efficiency as a selection tool. Journal of Animal Science 77 (1999) 1654-1658
153. Wilson M.E., Sonstegard T.S., Smith T.P.L., Fahrenkrug S.C., and Ford S.P. Differential gene expression during elongation in the preimplantation pig embryo. Genesis 26 (2000) 9-14
154. Wilson M.E., Fahrenkrug S.C., Smith T.P., Rohrer G.A., and Ford S.P. Differential expression of cyclooxygenase-2 around the time of elongation in the pig conceptus. Animal Reproduction Science 71 (2002) 229-237
155. Wollenhaupt K., Einspanier R., Gabler C., Schneider F., Kanitz W., and Brüssow K.P. Identification of the EGF/EGF-R system in the oviduct and endometrium of pigs in early stages of pregnancy and early conceptus. Experimental and Clinical Endocrinology & Diabetes 107 (1999) 530-538
156. Wood S.A., and Kaye P.L. Effects of epidermal growth factor on preimplantation mouse embryos. Journal of Reproduction and Fertility 85 (1989) 575-582
157. Wray N.R., and Goddard M.E. Increasing long-term response to selection. Genetics Selection Evolution 26 (1994) 431-451
158. Yelich J.V., Pomp D., and Geisert R.D. Detection of transcripts for retinoic acid receptors, retinol binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus. Biology of Reproduction 57 (1997) 286-294
159. Yelich J.V., Pomp D., and Geisert R.D. Ontogeny of elongation and gene expression in the early developing porcine conceptus. Biology of Reproduction 57 (1997) 1256-1265
160. Zhang W., and Smith C. The use of marker assisted selection with linkage disequilibrium: the effects of several additional factors. Theoretical and Applied Genetics 86 (1993) 492-496
161. Zhang W., Haley C., and Moran C. Alignment of the PiGMaP and USDA linkage maps of porcine chromosomes 2 and 5. Animal Genetics 26 (1995) 361-364
162. 2α production. Biology of Reproduction 46 (1992) 932-936
163. Zhang Y., Paria B.C., Dey S.K., and Davis D.L. Characterization of the epidermal growth factor receptor in preimplantation pig conceptuses. Developmental Biology 151 (1992) 617-621