Properties of a trifluoroleucine-resistant mutant of Saccharomyces cerevisiae

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 7, 2006, Pages 1776-1779

  Oba, Takahiro ^a   Yamamoto, Yoshitsugu ^b   Nomiyama, Shuji ^a   Suenaga, Hikaru ^a   Muta, Shigeru ^b   Tashiro, Kosuke ^b   Kuhara, Satoru ^b  

^a FUKUOKA INDUSTRIAL TECHNOLOGY CENTER   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

5,5,5 trifluoro DL leucine; DNA microarray analysis; i AmOH; Leucine feedback inhibition; Saccharomyces cerevisiae

Indexed keywords

AMINO ACIDS; DNA; GENES; METABOLISM;

5,5,5-TRIFLUORO-DL-LEUCINE; DNA MICROARRAY ANALYSIS; I-AMOH; LEUCINE FEEDBACK INHIBITION; SACCHAROMYCES CEREVISIAE;

MUTAGENS;

2 ISOPROPYLMALATE SYNTHASE; 5',5',5' TRIFLUOROLEUCINE; 5',5',5'-TRIFLUOROLEUCINE; DRUG DERIVATIVE; ISOPENTYL ALCOHOL; LEU4 PROTEIN, S CEREVISIAE; LEUCINE; PENTANOL; SACCHAROMYCES CEREVISIAE PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; UPREGULATION;

2-ISOPROPYLMALATE SYNTHASE; DRUG RESISTANCE, FUNGAL; LEUCINE; MUTATION; PENTANOLS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UP-REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 33746470236     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.50640     Document Type: Article

References (25)

1. Casalone, E., Fia, G., Barberio, C., Cavalieri, D., Turbanti, L., and Polsinelli, M., Genetic and biochemical characterization of Saccharomyces cerevisiae mutants resistant to trifluoroleucine. Res. Microbiol., 148, 613-623 (1997).
2. Bendoni, B., Cavalieri, D., Casalone, E., Polsinelli, M., and Barberio, C., Trifluoroleucine resistance as a dominant molecular marker in transformation of strains of Saccharomyces cerevisiae isolated from wine. FEMS Microbiol. Lett., 180, 229-233 (1999).
3. Suizu, T., Kotani, K., Yasui, K., Ichikawa, E., Kawato, A., and Imayasu, S., Introduction of a feedback resistant α-isopropylmalate synthase gene of Saccharomyces cerevisiae into sake yeast. J. Ferm. Bioeng., 77, 119-124 (1994).
4. Xiao, W., and Rank, G. H., The yeast ILV2 gene is under general amino acid control. Genome, 30, 984-986 (1988).
5. Holmberg, S., and Petersen, J. G., Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. Curr. Genet., 13, 207-217 (1988).
6. Svetlov, V. V., and Cooper, T. G., Compilation and characteristics of dedicated transcription factors in Saccharomyces cerevisiae. Yeast, 11, 1439-1484 (1995).
7. Brisco, P. R., Cunningham, T. S., and Kohlhaw, G. B., Cloning, disruption and chromosomal mapping of yeast LEU3, a putative regulatory gene. Genetics, 115, 91-99 (1987).
8. Friden, P., and Schimmel, P., LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes. Mol. Cell. Biol., 7, 2708-2717 (1987).
9. Sze, J. Y., Woontner, M., Jaehning, J. A., and Kohlhaw, G. B., In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science, 258, 1143-1145 (1992).
10. Hu, Y., Cooper, T. G., and Kohlhaw, G. B., The Saccharomyces cerevisiae Leu3 protein activates expression of GDH1, a key gene in nitrogen assimilation. Mol. Cell. Biol., 15, 52-57 (1995).
11. Nielsen, P. S., van den Hazel, B., Didion, T., de Boer, M., Jorgensen, M., Planta, R. J., Kielland-Brandt, M. C., and Andersen, H. A., Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2. Mol. Gen. Genet., 264, 613-622 (2001).
12. Grauslund, M., Didion, T., Kielland-Brandt, M. C., and Andersen, H. A., BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae. Biochem. Biophys. Acta, 1269, 275-280 (1995).
13. Ashida, S., Ichikawa, E., Suginami, K., and Imayasu, S., Isolation and application of mutants producing sufficient isoamyl acetate, a sake flavor component. Agric. Biol. Chem., 51, 2061-2065 (1987).
14. Cavalieri, D., Casalone, E., Bendoni, B., Fia, G., Polsinelli, M., and Barberio, C., Trifluoroleucine resistance and regulation of α- isopropylmalate synthase in Saccharomyces cerevisiae. Mol. Gen. Genet., 261, 152-160 (1999).
15. Oba, T., Nomiyama, S., Hirakawa, H., Tashiro, K., and Kuhara, S., Asp578 in LEU4 is one of key residues for leucine feedback inhibition release in sake yeast. Biosci. Biotechnol. Biochem., 69, 1270-1273 (2005).
16. Uehigashi, H., Kato, R., Kawamoto, O., Seki, M., Nakagawa, E., Ojima, Y., Nagata, S., and Misono, H., Breeding of sake yeasts that produce enhanced levels of flavor by transformation mutated LEU4 gene or leudh gene. J. Brew. Soc. Japan (in Japanese), 96, 129-136 (2001).
17. Matsuda, Y., Ishigaki, H., and Koseki, T., Identification of mutated genes of a highly flavor-producing sake yeast (Part 3). J. Brew. Soc. Japan (in Japanese), 99, 127-133 (2004).
18. Koehrer, K., and Domdey, H., Preparation of high molecular weight RNA. Methods Enzymol., 194, 398-401 (1991).
19. DeRisi, J. L., Iyer, V. R., and Brown, P. O., Exploring the metabolic and genetic control of gene expression on a genomic scale. Science, 278, 680-686 (1997).
20. Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., and Sherlock, G., GO::TermFinder: open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes. Bioinformatics, 20, 3710-3715 (2004).
21. Andreadis, A., Hsu, Y. P., Kohlhaw, G. B., and Schimmel, P., Nucleotide sequence of yeast LEU2 shows 50-noncoding region has sequences cognate to leucine. Cell, 31, 319-325 (1982).
22. Nagasu, T., and Hall, B. D., Nucleotide sequence of the GDH gene coding for the NADP-specific glutamate dehydrogenase of Saccharomyces cerevisiae. Gene, 37, 247-253 (1985).
23. Schreve, J., and Garrett, J. M., The branched-chain amino acid permease gene of Saccharomyces cerevisiae, BAP2, encodes the high-affinity leucine permease (S1). Yeast, 13, 435-439 (1997).
24. Bauer, B. E., Wolfger, H., and Kuchler, K., Inventory and function of yeast ABC protein: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim. Biophys. Acta, 1461, 217-236 (1999).
25. Hirata, D., Yano, K., Miyahara, K., and Miyakawa, T., Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr. Genet., 26, 285-294 (1994).