Multiple vaccine and pyridostigmine interactions: Effects on cognition, muscle function and health outcomes in marmosets

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 2, 2006, Pages 207-218

  Stevens, D ^a   Scott, E A M ^a   Bowditch, A P ^a   Griffiths, G D ^a   Pearce, P C ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

AChE; Cognition; Health; Muscle function; Non human primate; Pyridostigmine bromide; Vaccines

Indexed keywords

ANTHRAX VACCINE; CHOLERA TOXIN; HEPATITIS B VACCINE; MENINGOCOCCUS VACCINE; PERTUSSIS VACCINE; PYRIDOSTIGMINE; TETANUS TOXOID; TYPHOID VACCINE; YELLOW FEVER VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAM; FEMALE; MALE; MUSCLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; SLEEP; STATISTICAL ANALYSIS; TREATMENT OUTCOME; UNITED KINGDOM; UNITED STATES; VACCINATION;

ACETYLCHOLINESTERASE; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; BODY WEIGHT; CALLITHRIX; COGNITION; CREATININE; DISCRIMINATION (PSYCHOLOGY); FEMALE; ISOCITRATE DEHYDROGENASE; MALE; MUSCLE WEAKNESS; MUSCLES; PERSIAN GULF SYNDROME; PYRIDOSTIGMINE BROMIDE; UREA; VACCINES;

CALLITHRIX JACCHUS; PRIMATES;

EID: 33746305120     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.04.020     Document Type: Article

References (59)

1. Amato A.A., McVey A., Cha C., Matthews E.C., Jackson C.E., Kleingunther R., et al. Evaluation of neuromuscular symptoms in veterans of the Persian Gulf War. Neurology 48 (1997) 4-12
2. Baker D.J., and Sedgwick E.M. Single fibre electromyographic changes in man after organophosphate exposure. Hum Exp Toxicol 15 (1996) 369-375
3. Border P., and Norton M. Gulf War Illnesses - dealing with the uncertainties. Parliamentary Office of Science and Technology Report (1997). 1 897941 66 8 [main authors]
4. Bowman P.D., Schuschereba S.T., Johnson T.W., Woo F.J., McKinney L., Wheeler C.R., et al. Myopathic changes in the diaphragm of rats fed pyridostigmine bromide sub-chronically. Fundam Appl Toxicol 13 (1989) 110-117
5. Cherry N., Creed F., Silman A., Dunn G., Baxter D., Smedley J., et al. Health and exposures of United Kingdom Gulf War veterans: Part I. The pattern and extent of ill health. Occup Environ Med 58 (2001) 291-298
6. Coker W.J., Bhatt B.M., Blatchley N.F., and Graham J.T. Clinical findings for the first 1000 Gulf War veterans in the Ministry of Defence's medical assessment programme. BMJ 318 (1999) 290-294
7. Cook J.E., Kolka M.A., and Wenger C.B. Chronic pyridostigmine bromide administration: side effects among soldiers working in a desert environment. Mil Med 157 (1992) 250-254
8. Crofts H.S., Muggleton N.G., Bowditch A.P., Pearce P.C., Nutt D.J., and Scott E.A.M. Home cage presentation of complex discrimination tasks to marmosets and rhesus monkeys. Lab Anim 33 (1999) 207-214
9. David A.S., Farrin L., Hull L., Unwin C., Wessely S., and Wykes T. Cognitive functioning and disturbances of mood in UK veterans of the Persian Gulf War: a comparative study. Psychol Med 32 (2002) 357-370
10. de Vries M., Soetekouw P.M., Van Der Meer J.W., and Bleijenberg G. Fatigue in Cambodia veterans. QJM 93 (2000) 283-289
11. Drake-Baumann R., and Seil F.J. Effects of exposure to low-dose pyridostigmine on neuromuscular junctions in vitro. Muscle Nerve 22 (1999) 696-703
12. Ellman G.L., Courtney D., Andres V., and Featherstone R.M. A new and rapid colourimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7 (1961) 88-95
13. Friedman A., Kaufer D., Shemer J., Hendler I., Soreq H., and Tur-Kaspa I. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat Med 2 (1996) 1382-1385
14. Fukuda K., Nisenbaum R., Stewart G., Thompson W.W., Robin L., Washko R.M., et al. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 280 (1998) 981-988
15. Golomb B.A., and Anthony C.R. A review of the scientific literature as it pertains to Gulf War Illnesses. Pyridostigmine bromide (1999). http://www.rand.org/publications/CT/CT164
16. Grant D.A., and Berg E.A. A behavioural analysis of degree of reinforcement and ease of shifting to responses in a Weigl-type card-sorting problem. J Exp Psychol 38 (1948) 404-411
17. Grauer E., Alkalai D., Kapon J., Cohen G., and Raveh L. Stress does not enable pyridostigmine to inhibit brain cholinesterase after parenteral administration. Toxicol Appl Pharmacol 164 (2000) 301-304
18. Gray G.C., Kaiser K.S., Hawksworth A.W., Hall F.W., and Barrett-Connor E. Increased postwar symptoms and psychological morbidity among U.S. Navy Gulf War veterans. Am J Trop Med Hyg 60 (1999) 758-766
19. Griffiths G.D., Hornby R.J., Stevens D.J., Scott L.A., and Upshall D.G. Biological consequences of multiple vaccine and pyridostigmine pretreatment in the guinea pig. J Appl Toxicol 21 (2001) 59-68
20. Griffiths GD, Hornby RJ, Jagger CP, Brown AP, Stoten A, Pearce PC, Scott L Pritchard DI. Development of methods to measure humoral immune responses against selected antigens in the common marmoset (Callithrix jacchus) and the effect of pyridostigmine bromide administration. Int Immunopharmacol submitted for publication.
21. Haley R.W., Kurt T.L., and Hom J. Is there a Gulf War syndrome? Searching for syndromes by factor analysis of symptoms. JAMA 227 (1997) 215-222
22. Haley R.W., Hom J., Roland P.S., Bryan W.W., Van Ness P.C., Bonte F.J., et al. Evaluation of neurologic function in Gulf War veterans. JAMA 227 (1997) 223-230
23. 1H MR spectroscopy. Radiology 215 (2000) 807-817
24. Haley R.W., Fleckenstein J.L., Marshall W.W., McDonald G.G., Kramer G.L., and Petty F. Effect of basal ganglia injury on central dopamine activity in Gulf War syndrome. Arch Neurol 57 (2000) 1280-1285
25. Hudson C.S., Foster R.E., and Kahng M.W. Neuromuscular toxicity of pyridostigmine bromide in the diaphragm, extensor digitorum longus and soleus muscles of the rat. Fundam Appl Toxicol 5 (1985) S260-S269
26. Hudson C.S., Foster R.E., and Kahng M.W. Ultrastructural effects of pyridostigmine on neuromuscular junctions in rat diaphragm. Neurotoxicology 7 (1986) 167-185
27. Kaiser K.S., Hawksworth A.W., and Gray G.C. Pyridostigmine bromide intake during the Persian Gulf War is not associated with postwar handgrip strength. Mil Med 165 (2000) 165-168
28. Kang H.K., Mahan C.M., Lee K.Y., Magee C.A., and Murphy F.M. Illnesses among United States veterans of the Gulf War: a population-based survey of 30,000 veterans. J Occup Environ Med 42 (2000) 491-501
29. Kaufer D., Friedman A., and Soreq H. The vicious circle of stress and anticholinesterase responses. Neuroscientist 5 (1999) 173-183
30. Kelly S.S., Ferry C.B., and Bamforth J.P. The effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles. Br J Pharmacol 99 (1990) 721-726
31. Kelly S.S., Ferry C.B., Bamforth J.P., and Das S.K. Protection against the effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles. Br J Pharmacol 107 (1992) 867-872
32. Lallement G., Foquin A., Baubachon D., Burckhart M.F., Carpentier P., and Canini F. Heat stress, even extreme, does not induce penetration of pyridostigmine into the brain of guinea pigs. NeuroToxicology 19 (1998) 759-766
33. Lange G., Tiersky L.A., DeLuca J., Scharer J.B., Policastro T., Fielder N., et al. Cognitive functioning in Gulf War Illness. J Clin Exp Neuropsychol 23 (2001) 240-249
34. Lee H.A., Gabriel R., Bale A.J., Bolton P., and Blatchley N. Clinical findings of the second 1000 UK Gulf War Veterans who attended the Ministry of Defence's Medical Assessment Programme. J R Army Med Corps 147 (2001) 153-160
35. Lee H.A., Gabriel R., Bolton P., Bale A.J., and Jackson M. Health status and clinical diagnoses of 3000 UK Gulf War Veterans. J R Soc Med 95 (2002) 491-497
36. Menon P.M., Nasrallah H.A., Reeves R.R., and Ali J.A. Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study. Brain Res 1009 (2004) 189-194
37. Muggleton N.G., Crofts H.S., Pearce P.C., Bowditch A.P., and Scott E.A.M. The acquisition of a computer controlled touchscreen discrimination task by common marmosets in the home cage. J Psychopharmacol 11 (1997) A68
38. Muggleton N.G., Bowditch A.P., Crofts H.S., Scott E.A.M., and Pearce P.C. Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus). Psychopharmacology 166 (2003) 212-220
39. Muggleton N.G., Smith A.J., Scott E.A.M., Wilson S.J., and Pearce P.C. A long term study of the effects of diazinon on sleep, the electrocorticogram and cognitive behaviour in common marmosets. J Psychopharmacol 19 (2005) 455-466
40. Murphy F.M., Kang H., Dalager N.A., Lee K.Y., Allen R.E., Mather S.H., et al. The health status of Gulf War veterans: lessons learned from the Department of Veterans Affairs health registry. Mil Med 164 (1999) 327-331
41. Pearce P.C., Crofts H.S., Muggleton N.G., and Scott E.A.M. Concurrent monitoring of EEG and performance in the common marmoset (Callithrix jacchus): a methodological approach. Physiol Behav 63 (1998) 591-599
42. Pearce P.C., Crofts H.S., Muggleton N.G., Ridout D., and Scott E.A.M. The effects of acutely administered low dose sarin on cognitive behaviour and the electroencephalogram in the common marmoset. J Psychopharmacol 13 (1999) 128-135
43. Proctor S.P., Heeren T., White R.F., Wolfe J., Borgos M.S., Davis J.D., et al. Health status of Persian Gulf War veterans: self-reported symptoms, environmental exposures and the effect of stress. Int J Epidemiol 27 (1998) 1000-1010
44. Ridley R.M., Murray T.K., Johnson J.A., and Baker HF. Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs. Brain Res 376 (1986) 108-116
45. Rijpkema S.G., Adams T., Rigsby P., Xing D.K., and Corbel M.J. Investigation in a model system of the effects of combinations of anthrax and pertussis vaccines administered to service personnel in the 1991 Gulf War. Hum Vaccines 1 (2005) 165-169
46. Roberts A.C. Comparison of cognitive function in humans and non-human primates. Cogn Brain Res 3 (1996) 319-327
47. Roberts A.C., Robbins T.W., and Everitt B.J. The effects of intradimensional and extradimensional shifts on visual discrimination learning in humans and non-human primates. Q J Exp Psychol 40B (1988) 321-341
48. Roberts A.C., Robbins T.W., Everitt B.J., and Muir J.L. A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in marmosets. Neuroscience 47 (1992) 251-264
49. Rose M.R., Sharief M.K., Priddin J., Nikolaou V., Hull L., Unwin C., et al. Evaluation of neuromuscular symptoms in UK Gulf War veterans: a controlled study. Neurology 63 (2004) 1681-1687
50. Sahakian B.J., and Coull J.T. Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB. Acta Neurol Scand Suppl 149 (1993) 29-35
51. Sahakian B.J., Downes J.J., Eagger S., Evenden J.L., Levy R., Philpot M.P., et al. Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type. Neuropsychologia 28 (1990) 1197-1213
52. Scremin O.U., Shih T.M., Huynh L., Roch M., Booth R., and Jenden D.J. Delayed neurologic and behavioral effects of subtoxic doses of cholinesterase inhibitors. J Pharmacol Exp Ther 304 (2003) 1111-1119
53. Sharief M.K., Priddin J., Delamont R.S., Unwin C., Rose M.R., David A., et al. Neurophysiologic analysis of neuromuscular symptoms in UK Gulf War veterans. Neurology 59 (2002) 1518-1525
54. Sinton C.M., Fitch T.E., Petty F., and Haley R.W. Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the rat. Toxicol Appl Pharmacol 165 (2000) 99-105
55. Smith A.P. Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle. J Pharm Pharmacol 45 (1993) 176-181
56. Somani S.M. Metabolism and pharmacokinetics of pyridostigmine in rats after multiple dosing. Pharmacologist 25 (1983) 97
57. Spinelli S., Pennanen L., Dettling A.C., Feldon J., Higgins G.A., and Pryce C.R. Performance of the marmoset monkey on computerised tasks of attention and working memory. Cogn Brain Res 19 (2004) 123-137
58. Stevens D.J., Hornby R.J., Cook D.L., Griffiths G.D., Scott E.A.M., and Pearce P.C. A simple method for assessing muscle function in common marmoset. Lab Anim 39 (2005) 162-168
59. Unwin C., Blatchley N., Coker W., Ferry S., Hotopf M., Hull L., et al. Health of UK servicemen who served in Persian Gulf War. Lancet 353 (1999) 169-178