Gene mutation and aneuploidy might cooperate to carcinogenesis by dysregulation of asymmetric division of adult stem cells

Medical Hypotheses

Volumn 67, Issue 4, 2006, Pages 995-996

  Zhang, Feng ^a   Zhao, Daqing ^a   Chen, Guangsheng ^a   Li, Qing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CARCINOGENESIS; CARCINOMA; CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL RENEWAL; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; DNA STRAND; DNA SYNTHESIS; GENE AMPLIFICATION; GENE MUTATION; HUMAN; LETTER; ONCOGENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

ADULT; ANEUPLOIDY; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; STEM CELLS;

EID: 33746264950     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.043     Document Type: Letter

References (11)

1. Beachy P.A., Karhadkar S.S., and Berman D.M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432 (2004) 324-331
2. Wodarz A. Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts. Curr Opin Cell Biol 17 (2005) 475-481
3. Wodarz A., and Gonzalez C. Connecting cancer to the asymmetric division of stem cells. Cell 124 (2006) 1121-1123
4. Clevers H. Stem cells, asymmetric division and cancer. Nat Genet 37 (2005) 1027-1028
5. Prehn R.T. Many growth factors may not be growth factors. Cancer Res 52 (1992) 501-507
6. Duesberg P. Does aneuploidy or mutation start cancer?. Science 307 (2005) 41
7. Woo R.A., and Poon R.Y. Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev 18 (2004) 1317-1330
8. Akagi T., Sasai K., and Hanafusa H. Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc Natl Acad Sci USA 100 (2003) 13567-13572
9. Potten C.S., Owen G., and Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 115 (2002) 2381-2388
10. Karpowicz P., Morshead C., Kam A., Jervis E., Ramunas J., Cheng V., and van der Kooy D. Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 170 (2005) 721-732
11. Zhang F., and Li Q. Aneuploidy-promoted immortal DNA strands to random separation is a root cause of cancer. Med Hypotheses 65 (2005) 1200-1201