Aneuploidy-promoted immortal DNA strands to random separation is a root cause of cancer [6]

Medical Hypotheses

Volumn 65, Issue 6, 2005, Pages 1200-1201

  Zhang, Feng ^a   Li, Qing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ANEUPLOIDY; CANCER; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CHROMATIN; CHROMOSOME; CHROMOSOME NUMBER; CHROMOSOME STRUCTURE; DNA STRAND; GENE MUTATION; LETTER; PRIORITY JOURNAL; STEM CELL;

ANEUPLOIDY; CHROMOSOME ABERRATIONS; CHROMOSOME SEGREGATION; DNA DAMAGE; DNA REPLICATION; DNA, NEOPLASM; MODELS, GENETIC; MODELS, STATISTICAL; NEOPLASMS; PRECANCEROUS CONDITIONS;

EID: 26444579791     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.07.005     Document Type: Letter

References (6)

1. C.S. Potten, G. Owen, and D. Booth Intestinal stem cells protect their genome by selective segregation of template DNA strands J Cell Sci 115 2002 2381 2388
2. J.R. Merok, J.A. Lansita, J.R. Tunstead, and J.L. Sherley Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics Cancer Res 62 2002 6791 6795
3. G.H. Smith Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands Development 132 2005 681 687
4. P.A. Beachy, S.S. Karhadkar, and D.M. Berman Tissue repair and stem cell renewal in carcinogenesis Nature 432 2004 324 331
5. F. Mitelman, F. Mertens, and B.A. Johansson Breakpoint map of recurrent chromosomal rearrangements in human neoplasia Nat Genet 15 1997 417 474
6. K.L. Manchester Theodor Boveri and the origin of malignant tumours Trends Cell Biol 5 1995 384 387