Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families

World Journal of Gastroenterology

Volumn 12, Issue 25, 2006, Pages 4074-4077

  Wang, Xu Lin ^a   Yuan, Ying ^a   Zhang, Su Zhan ^a   Cai, Shan Rong ^a   Huang, Yan Qin ^a   Jiang, Qiang ^a   Zheng, Shu ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Colorectal cancer; DNA mutation analysis; Hereditary nonpolyposis; High pressure liquid Chromatography; Oncogenes

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2;

ADULT; AGED; ARTICLE; CANCER GENETICS; CHINA; CHINESE; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DISEASE ASSOCIATION; EXON; FAMILY HISTORY; FAMILY STUDY; FEMALE; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; GERM LINE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MULTIPLE CANCER; NONSENSE MUTATION; ONSET AGE; PATHOGENICITY; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER; TUMOR LOCALIZATION;

EID: 33746238293     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i25.4074     Document Type: Article

References (17)

1. Lynch HT, Smyrk T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review. Cancer 1996; 78; 1149-1167
2. Yuan Y, Huang YQ, Cai SR, Song YM, Zheng S, Zhang SZ. Genetic characterization of Chinese hereditary non-polyposis colorectal cancer by DHPLC and multiplex PCR. Jpn J Clin Oncol 2004; 34: 660-666
3. Kurzawski G, Safranow K, Suchy J, Chlubek D, Scott RJ, Lubinski J. Mutation analysis of MLH1 and MSH2 genes performed by denaturing high-performance liquid chromatography. J Biochem Biophys Methods 2002; 51: 89-100
4. Xiao W, Oefner PJ. Denaturing high-performance liquid chromatography: A review. Hum Mutat 2001; 17: 439-474
5. Weber TK, Conlon W, Petrelli NJ, Rodriguez-Bigas M, Keitz B, Pazik J, Farrell C, O'Malley L, Oshalim M, Abdo M, Anderson G, Stoler D, Yandell D. Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees. Cancer Res 1997; 57: 3798-3803
6. Holinski-Feder E, Muller-Koch Y, Friedl W, Moeslein G, Keller G, Plaschke J, Ballhausen W, Gross M, Baldwin-Jedele K, Jungck M, Mangold E, Vogelsang H, Schackert HK, Lohsea P, Murken J, Meitinger T. DHPLC mutation analysis of the hereditary nonpolyposis colon cancer (HNPCC) genes hMLH1 and hMSH2. J Biochem Biophys Methods 2001; 47: 21-32
7. Wang Y, Friedl W, Lamberti C, Nothen MM, Kruse R, Propping P. A novel missense mutation in the DNA mismatch repair gene hMLH1 present among East Asians but not among Europeans. Hum Hered 1998; 48: 87-91
8. Sasaki S, Tokino T, Miyatsu T, Muto T, Nakamura Y. Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system. Hum Mutat 1997; 9: 164-171
9. Kim JC, Kim HC, Roh SA, Koo KH, Lee DH, Yu CS, Lee JH, Kim TW, Lee HL, Beck NE, Bodmer WF. hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. Cancer Detect Prev 2001; 25: 503-510
10. Scott RJ, McPhillips M, Meldrum CJ, Fitzgerald PE, Adams K, Spigelman AD, du Sart D, Tucker K, Kirk J. Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds. Am J Hum Genet 2001; 68: 118-127
11. Miyaki M, Konishi M, Muraoka M, Kikuchi-Yanoshita R, Tanaka K, Iwama T, Mori T, Koike M, Ushio K, Chiba M. Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients. J Mol Med 1995; 73: 515-520
12. Syngal S, Fox EA, Li C, Dovidio M, Eng C, Kolodner RD, Garber JE. Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing. JAMA 1999; 282: 247-253
13. Nomura S, Sugano K, Kashiwabara H, Taniguchi T, Fukayama N, Fujita S, Akasu T, Moriya Y, Ohhigashi S, Kakizoe T, Sekiya T. Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds. Biochem Biophys Res Commun 2000; 271: 120-129
14. Velayos FS, Lee SH, Qiu H, Dykes S, Yiu R, Terdiman JP, Garcia-Aguilar J. The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer. J Gastrointest Surg 2005; 9: 329-335
15. Liu SR, Zhao B, Wang ZJ, Wan YL, Huang YT. Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. World J Gastroenterol 2004; 10: 2647-2651
16. Kurzawski G, Safranow K, Suchy J, Chlubek D, Scott RJ, Lubinski J. Mutation analysis of MLH1 and MSH2 genes performed by denaturing high-performance liquid chromatography. J Biochem Biophys Methods 2002; 51: 89-100
17. Yuan Y, Zheng S. Mutations of hMLH1 and hMSH2 genes in suspected hereditary nonpolyposis colorectal cancer. Zhonghua Yi Xue Za Zhi 1999; 79: 346-348