Infected Chronic Wounds Show Different Local and Systemic Arginine Conversion Compared With Acute Wounds

Journal of Surgical Research

Volumn 134, Issue 2, 2006, Pages 205-214

  Debats, Iris B J G ^a   Booi, Darren ^a   Deutz, Nicolaas E P ^a   Buurman, Wim A ^a   Boeckx, Willy D ^a   van der Hulst, Rene R W J ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

acute wounds; arginine; chronic wounds; human; infection; metabolism; wound healing

Indexed keywords

AMINO ACID; ARGINASE; ARGININE; CITRULLINE; NITRATE; NITRITE; ORNITHINE;

ACUTE DISEASE; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MICROBIOLOGICAL EXAMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; WOUND FLUID; WOUND HEALING IMPAIRMENT; WOUND INFECTION;

ACUTE DISEASE; ADULT; AMINO ACIDS; ARGINASE; ARGININE; BODY FLUIDS; CHRONIC DISEASE; CITRULLINE; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRITES; ORNITHINE; PROSPECTIVE STUDIES; WOUND HEALING; WOUND INFECTION; WOUNDS AND INJURIES;

EID: 33746228380     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.03.005     Document Type: Article

References (75)

1. Evans J.M., Andrews K.L., Chutka D.S., et al. Pressure ulcers. prevention and management. Mayo Clin Proc 70 (1995) 789
2. Smith D.M. Pressure ulcers in the nursing home. Ann Intern Med 123 (1995) 433
3. Schaffer M.R., Tantry U., Ahrendt G.M., et al. Acute protein-calorie malnutrition impairs wound healing. a possible role of decreased wound nitric oxide synthesis. J Am Coll Surg 184 (1997) 37
4. Breslow R.A., Hallfrisch J., Guy D.G., et al. The importance of dietary protein in healing pressure ulcers. J Am Geriatr Soc 41 (1993) 357
5. Houwing R.H., Rozendaal M., Wouters-Wesseling W., et al. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin Nutr 22 (2003) 401
6. Thomas D.R. Improving outcome of pressure ulcers with nutritional interventions. a review of the evidence. Nutrition 17 (2001) 121
7. Witte M.B., Thornton F.J., Tantry U., et al. L-Arginine supplementation enhances diabetic wound healing. involvement of the nitric oxide synthase and arginase pathways. Metabolism 51 (2002) 1269
8. Angele M.K., Nitsch S.M., Hatz R.A., et al. L-arginine. a unique amino acid for improving depressed wound immune function following hemorrhage. Eur Surg Res 34 (2002) 53
9. Shi H.P., Most D., Efron D.T., et al. Supplemental L-arginine enhances wound healing in diabetic rats. Wound Repair Regen 11 (2003) 198
10. Kirk S.J., Hurson M., Regan M.C., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 114 (1993) 155 discussion 160
11. Efron D., and Barbul A. Role of arginine in immunonutrition. J Gastroenterol 35 Suppl (2000) 20
12. Barbul A., Lazarou S.A., Efron D.T., et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 108 (1990) 331 discussion 336
13. Arbss M.A., Ferrando J.M., Vidal J., et al. Early effects of exogenous arginine after the implantation of prosthetic material into the rat abdominal wall. Life Sci 67 (2000) 2493
14. Albina J.E., Abate J.A., and Mastrofrancesco B. Role of ornithine as a proline precursor in healing wounds. J Surg Res 55 (1993) 97
15. Pollock J.S., Webb W., Callaway D., et al. Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation. Surgery 129 (2001) 341
16. Norris K.A., Schrimpf J.E., Flynn J.L., et al. Enhancement of macrophage microbicidal activity. supplemental arginine and citrulline augment nitric oxide production in murine peritoneal macrophages and promote intracellular killing of Trypanosoma cruzi. Infect Immun 63 (1995) 2793
17. Shashidharan M., Lin K.M., Ternent C.A., et al. Influence of arginine dietary supplementation on healing colonic anastomosis in the rat. Dis Colon Rectum 42 (1999) 1613
18. Schaffer M.R., Tantry U., Gross S.S., et al. Nitric oxide regulates wound healing. J Surg Res 63 (1996) 237
19. Witte M.B., and Barbul A. Role of nitric oxide in wound repair. Am J Surg 183 (2002) 406
20. Schaffer M.R., Tantry U., Thornton F.J., et al. Inhibition of nitric oxide synthesis in wounds. pharmacology and effect on accumulation of collagen in wounds in mice. Eur J Surg 165 (1999) 262
21. Yamasaki K., Edington H.D., McClosky C., et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 101 (1998) 967
22. Thornton F.J., Schaffer M.R., Witte M.B., et al. Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds. Biochem Biophys Res Commun 246 (1998) 654
23. Shi H.P., Efron D.T., Most D., et al. Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice. Surgery 128 (2000) 374
24. Morris Jr. S.M. Regulation of enzymes of urea and arginine synthesis. Annu Rev Nutr 12 (1992) 81
25. Maeno Y., Takabe F., Inoue H., et al. A study on the vital reaction in wounded skin. simultaneous determination of histamine and polyamines in injured rat skin by high-performance liquid chromatography. Forensic Sci Int 46 (1990) 255
26. Lesiewicz J., and Goldsmith L.A. Inhibition of rat skin ornithine decarboxylase by nitrofurazone. Arch Dermatol 116 (1980) 1225
27. Dolynchuk K.N., Bendor-Samuel R., and Bowness J.M. Effect of putrescine on tissue transglutaminase activity in wounds. decreased breaking strength and increased matrix fucoprotein solubility. Plast Reconstr Surg 93 (1994) 567
28. Adams E., and Frank L. Metabolism of proline and the hydroxyprolines. Annu Rev Biochem 49 (1980) 1005
29. Wu G., and Morris Jr. S.M. Arginine metabolism. nitric oxide and beyond. Biochem J 336 (1998) 1
30. Yu H., Yoo P.K., Aguirre C.C., et al. Widespread expression of arginase I in mouse tissues. Biochemical and physiological implications. J Histochem Cytochem 51 (2003) 1151
31. Bansal V., and Ochoa J.B. Arginine availability, arginase, and the immune response. Curr Opin Clin Nutr Metab Care 6 (2003) 223
32. Bronte V., Serafini P., Mazzoni A., et al. L-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol 24 (2003) 302
33. Lee J., Ryu H., Ferrante R.J., et al. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci USA 100 (2003) 4843
34. Albina J.E., Mills C.D., Henry Jr. W.L., et al. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol 144 (1990) 3877
35. Thomson P.D. Immunology, microbiology, and the recalcitrant wound. Ostomy Wound Manage 46 (2000) 77S quiz 83S
36. Mahoney E., Reichner J., Bostom L.R., et al. Bacterial colonization and the expression of inducible nitric oxide synthase in murine wounds. Am J Pathol 161 (2002) 2143
37. Edwards R., and Harding K.G. Bacteria and wound healing. Curr Opin Infect Dis 17 (2004) 91
38. Schultz G.S., Sibbald R.G., Falanga V., et al. Wound bed preparation. a systematic approach to wound management. Wound Repair Regen 11 Suppl (2003) S1
39. Krizek T.J., and Robson M.C. Evolution of quantitative bacteriology in wound management. Am J Surg 130 (1975) 579
40. van Eijk H.M., Rooyakkers D.R., and Deutz N.E. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr 620 (1993) 143
41. Bruins M.J., Soeters P.B., Lamers W.H., et al. L-arginine supplementation in hyperdynamic endotoxemic pigs. effect on nitric oxide synthesis by the different organs. Crit Care Med 30 (2002) 508
42. Ikemoto M., Tsunekawa S., Awane M., et al. A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. Clin Biochem 34 (2001) 455
43. Lee R.H., Efron D., Tantry U., et al. Nitric oxide in the healing wound. a time-course study. J Surg Res 101 (2001) 104
44. Albina J.E., Mills C.D., Barbul A., et al. Arginine metabolism in wounds. Am J Physiol 254 (1988) E459
45. Witte M.B., Vogt N., Stuelten C., et al. Arginase acts as an alternative pathway of L-arginine metabolism in experimental colon anastomosis. J Gastrointest Surg 7 (2003) 378
46. Shi H.P., Fishel R.S., Efron D.T., et al. Effect of supplemental ornithine on wound healing. J Surg Res 106 (2002) 299
47. Chen S.Z., Li J., Li X.Y., et al. Effects of vacuum-assisted closure on wound microcirculation. an experimental study. Asian J Surg 28 (2005) 211
48. Saxena V, Hwang CW, Huang S, et al: Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg 114:1086; discussion 1097.
49. Nijveldt R.J., Prins H.A., Siroen M.P., et al. Low arginine plasma levels in patients after thoracoabdominal aortic surgery. Eur J Clin Nutr 54 (2000) 615
50. Yu Y.M., Ryan C.M., Castillo L., et al. Arginine and ornithine kinetics in severely burned patients. increased rate of arginine disposal. Am J Physiol Endocrinol Metab 280 (2001) E509
51. Ochoa J.B., Bernard A.C., O'Brien W.E., et al. Arginase I expression and activity in human mononuclear cells after injury. Ann Surg 233 (2001) 393
52. Kondrup J., Rasmussen H.H., Hamberg O., et al. Nutritional risk screening (NRS 2002). a new method based on an analysis of controlled clinical trials. Clin Nutr 22 (2003) 321
53. Kondrup J., Allison S.P., Elia M., et al. ESPEN guidelines for nutrition screening 2002. Clin Nutr 22 (2003) 415
54. Visse R., and Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases. structure, function, and biochemistry. Circ Res 92 (2003) 827
55. Bini A., Itoh Y., Kudryk B.J., et al. Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1). hydrolysis of the gamma Gly 404-Ala 405 peptide bond. Biochemistry 35 (1996) 13056
56. Schmidtchen A., Frick I.M., Andersson E., et al. Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Mol Microbiol 46 (2002) 157
57. Urdiales J.L., Medina M.A., and Sanchez-Jimenez F. Polyamine metabolism revisited. Eur J Gastroenterol Hepatol 13 (2001) 1015
58. Bachrach U., Wang Y.C., and Tabib A. Polyamines. new cues in cellular signal transduction. News Physiol Sci 16 (2001) 106
59. Abd-El-Aleem S.A., Ferguson M.W., Appleton I., et al. Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers. J Pathol 191 (2000) 434
60. Jude E.B., Boulton A.J., Ferguson M.W., et al. The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers. possible modulatory effects by transforming growth factor beta 1. Diabetologia 42 (1999) 748
61. Gotoh T., and Mori M. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol 144 (1999) 427
62. Anggard E. Nitric oxide. mediator, murderer, and medicine. Lancet 343 (1994) 1199
63. Stallmeyer B., Kampfer H., Kolb N., et al. The function of nitric oxide in wound repair. inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization. J Invest Dermatol 113 (1999) 1090
64. Lee P.C., Salyapongse A.N., Bragdon G.A., et al. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol 277 (1999) H1600
65. Lu C.D., Winteler H., Abdelal A., et al. The ArgR regulatory protein, a helper to the anaerobic regulator ANR during transcriptional activation of the arcD promoter in Pseudomonas aeruginosa. J Bacteriol 181 (1999) 2459
66. Theil E.C., Forsyth G.W., and Jones E.E. Expression of the arginine regulon of Escherichia coli W. evidence for a second regulatory gene. J Bacteriol 99 (1969) 269
67. Galkin A., Kulakova L., Sarikaya E., et al. Structural insight into arginine degradation by arginine deiminase, an antibacterial and parasite drug target. J Biol Chem 279 (2004) 14001
68. Roberts P.R., Black K.W., Santamauro J.T., et al. Dietary peptides improve wound healing following surgery. Nutrition 14 (1998) 266
69. Sarantos P., Abouhamze A., Abcouwer S., et al. Cytokines decrease glutaminase expression in human fibroblasts. Surgery 116 (1994) 276 discussion 283
70. Fitzpatrick D.W., and Fisher H. Carnosine, histidine, and wound healing. Surgery 91 (1982) 56
71. Collins N. Glutamine and wound healing. Adv Skin Wound Care 15 (2002) 233
72. Caldwell M.D. Local glutamine metabolism in wounds and inflammation. Metabolism 38 (1989) 34
73. Soeters P.B., van de Poll M.C., van Gemert W.G., et al. Amino acid adequacy in pathophysiological states. J Nutr 134 (2004) 1575S
74. Cetiner M., Sener G., Sehirli A.O., et al. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol Appl Pharmacol 209 (2005) 39
75. Cynober L.A. Metabolic and therapeutic aspects of amino acids in clinical nutrition. 2nd ed. (2004), CRC Press, Boca Raton, FL