Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers

Journal of Pathology

Volumn 191, Issue 4, 2000, Pages 434-442

  Abd El Aleem, Seham A ^a   Ferguson, Mark W J ^a   Appleton, Ian ^a   Kairsingh, Sadeo ^b   Jude, Edward B ^a   Jones, Kelly ^b   McCollum, Charles N ^b   Ireland, Grenham W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Arginase; Chronic venous ulcer; Endothelial nitric oxide synthase; Inducible nitric oxide synthase; Nitric oxide; Nitric oxide synthase

Indexed keywords

ARGINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CHRONIC DISEASE; CHRONIC VEIN INSUFFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INFLAMMATION; LEG ULCER; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; ULCER; WOUND HEALING;

EID: 0033837605     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S     Document Type: Article

References (58)

1. The causes of chronic venous ulceration
2. Causes of venous ulceration: A new hypothesis
3. Sequential changes in histological pattern and extracellular matrix deposition during the healing of chronic venous ulcers
4. Impaired endothelium dependent vasodilatation in patients with insulin-dependent diabetes mellitus
5. The pathogenesis of atherosclerosis: A perspective for the 1990s
6. Mechanism of disease: Regulatory function of endothelium
7. Nitric oxide synthase roles, tolls, and controls
8. Peroxynitrite-mediated tyrosine nitration catalysed by superoxide dismutase
9. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery
10. Role of nitric oxide synthesis in macrophage antimicrobial activity
11. Modulation of acute inflammation by endogenous nitric oxide
12. The role of nitric oxide in wound collagen deposition
13. Molecular cloning and functional expression of an inducible nitric oxide synthase from murine cell line
14. Induction of nitric oxide synthase in a subsets of murine pulmonary fibroblasts: Effect on fibroblast interleukin-6 production
15. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
16. Polyamine deprivation, malnutrition and tumour growth
17. Differential regulation of macrophage arginine metabolism: A proposed role in wound healing
18. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
19. Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages
20. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide like factor
21. Temporal expression of different pathways of L-arginine metabolism in healing wounds
22. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding
23. 2) in murine bone marrow-derived macrophages
24. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritis
25. Activation of inducible nitric oxide synthase in the brain of patients with multiple sclerosis
26. Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus
27. A proinflammatory activity of interleukin 8 in human skin: Expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes
28. Inducible nitric oxide synthase is upregulated in psoriasis
29. Nitric oxide, a key mediator in the early and late phase of carrageenan-induced rat paw inflammation
30. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation
31. Cyclo-oxygenase and nitric oxide synthase isoforms in carrageenan-induced pleurisy
32. Altered immune responses in mice lacking inducible nitric oxide synthase
33. Modulation of adjuvant arthritis by endogenous nitric oxide
34. Amelioration of chronic ileitis by nitric oxide synthase inhibitors
35. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase
36. Evidence that nitric oxide is an endogenous antiangiogenic mediator
37. Coronary angiogenesis. From morphometry to molecular biology and back
38. Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules
39. Nitric oxide promotes proliferation and plasminogen activator production by capillary venular endothelium through endogenous bFGF
40. Histamine increases vascular permeability via phospholipase C-NO synthase guanylate cyclase cascade
41. Increased expression of platelet-derived growth factor receptor alpha and beta and vascular endothelial growth factor in the skin of patients with chronic venous insufficiency
42. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
43. Nitric oxide: Physiology, pathophysiology and pharmacology
44. Immunohistochemical localization of nitric oxide synthase in normal human skin: Expression of endothelial-type and inducible-type nitric oxide synthas in keratinocytes
45. Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes
46. Evidence for nitric oxide mediated oxidative damage in chronic inflammation: Nitrotyrosine in serum and synovial fluid from rheumatoid patients
47. Aminoguanidine, an inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune encephalomyelitis in SJL mice
48. Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs
49. Activated murine macrophages induce apoptosis in tumour cells through nitric oxide dependent or nitric oxide independent mechanisms
50. Nitric oxide mediated apoptosis in 52 murine peritoneal macrophages
51. p53 expression in nitric oxide-induced apoptosis
52. Peroxynitrite induced apoptosis in HL-60 cells
53. Apoptosis and necrosis, two distinct events induced, respectively, by mild and intense insult with N-methyl-D asparate or nitric oxide superoxide in cortical cell culture
54. Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers associated with matrix degradation
55. Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration
56. Transforming growth factor-beta stimulates arginase activity in macrophage. Implications for the regulation of macrophage cytotoxicity
57. Increased collagen IV layer in the basal membrane area of the capillaries in severe chronic venous insufficiency
58. The role of nitric oxide synthase and arginase in diabetic foot ulceration. Modulatory effects of transforming growth factor beta